Best Science Medicine Podcast - BS without the BS

Dr James McCormack and Dr Michael Allan

2 FANS
The Best Science (BS) Medicine Podcast is a weekly presentation where practitioners can get evidence-based drug therapy content that is practical, entertaining and promotes healthy scepticism. In essence, we are the Medication Mythbusters. We present...Show More
Best
Newest
Looking for recently uploaded episodes
Episode 413: Is depression getting you down? We’ll bring you up. PART II

0:00 | Apr 29th

In episode 413, Mike and James continue with an overview of the evidence around depression. In this episode we talk about the evidence around the effectiveness of antidepressants and learn if they work, how well they work, and if any one is better th...Show More
Episode 412: Is depression getting you down? We’ll bring you up.

0:00 | Apr 19th

In episode 412, Mike and James do an overview of the evidence around depression. In this episode we talk about ruling out depression and the struggle of how to look at antidepressant evidence. Show notes Handout
Episode 410: The depressing evidence for antidepressants in the elderly

0:00 | Mar 21st

In episode 410, Mike, James, and Adrienne discuss the evidence around antidepressants in the elderly. We find 40% to 80% of elderly patients will recover with antidepressants, but a number of studies show no difference from placebo response rates. In...Show More
Episode 409: Are antibiotics in or out for abscess management?

0:00 | Mar 12th

In episode 409, Mike and James yet again welcome Adrienne from Red Deer to talk about whether or not we need to give antibiotics for drained abscesses. We find out that relatively, the benefit of increased cure is similar to the chance of side effect...Show More
Episode 408: Liar, liar, pants on fire – or at least a little bit of smoke

0:00 | Mar 4th

In episode 408, Mike and James talk about a couple of recent survey publications. One, which examined patient satisfaction around patient requests and denials of those requests. The other examined how often and why patients are not always honest abou...Show More
Episode 403: Therapeutic nihilists – I doubt that – PART IV

0:00 | Jan 4th

In episode 403, Mike and James finally finish up their clear demonstration as to why they aren’t therapeutic nihilists.  We focus on system/ecological issues and specifically primary care – the bottom line is things aren’t as bad as they sometimes se...Show More
Episode 402: Therapeutic nihilists – I doubt that – PART III

0:00 | Dec 27th, 2018

In episode 402, Mike and James continue to try to demonstrate beyond a shadow of a doubt that they aren’t therapeutic nihilists. We talk about treatments that really work for symptoms – antibiotics, corticosteroids, antidepressants, proton pump inhib...Show More
Episode 401: Therapeutic nihilists – I doubt that – PART II

0:00 | Dec 14th, 2018

In episode 401, Mike and James continue to try to show they aren’t therapeutic nihilists. We talk about the ballpark benefits of treating conditions like diabetes, with a focus on nutrition and activity to reduce cardiovascular risk. Show notes Hando...Show More
Episode 400: Therapeutic nihilists – I doubt that

0:00 | Dec 9th, 2018

In episode 400, Mike and James talk about why they think they aren’t therapeutic nihilists and what it means to be a healthy skeptic. We then have a much longer discussion (which will go into the next few episodes) about many of the treatments that r...Show More
Episode 399: What are the most common conditions in primary care?

0:00 | Nov 28th, 2018

In episode 399, Mike and James discuss a new paper researched and written by the Alberta gang. There are many reasons why patients are seen in primary care. This systematic review gives all the data on what are globally, the most common presenting co...Show More
Episode 398: Monoclonal antibodies – trying to put these agents into context – PART II

0:00 | Nov 13th, 2018

In episode 398, James and Mike continue their discussion of the evidence around the class of agents called monoclonal antibodies. In this podcast we focus on medications that have an effect on symptoms and at the end we put the entire class into pers...Show More
Episode 397: Monoclonal antibodies – trying to put these agents into context

0:00 | Nov 7th, 2018

In episode 397, James and Mike discuss the evidence around the class of medications called monoclonal antibodies. We talk a little bit about them as a whole and then talk specifically about 6 different agents and the trials that have looked at the ef...Show More
Episode 395: Less Pancakes, More Bacon? The Ketogenic Diet for Weight Loss

0:00 | Oct 9th, 2018

In episode 395, James and Mike bring in Adrienne to chew and digest all the evidence around the ketogenic diet. At the end we realize we will likely never have definitive evidence around these diet issues so we all commiserate by drowning our sorrows...Show More
Episode 394: Omega-3 Supplements for Dry Eye: Fishy evidence or a big catch?

0:00 | Sep 21st, 2018

In episode 394, James and Mike bring in Tina and Joey to look at all the evidence around omega-3 supplements and dry eye and, despite widespread use, the evidence is far from convincing. Show notes Tools for Practice
Episode 393: CPAP - Breath of life, or just hot air?

0:00 | Sep 12th, 2018

In episode 393, James and Mike bring in Tina to deal with the issue of the evidence around CPAP. We find out that there is little evidence that CPAP reduces CVD so it is all about does the person feel better while on it – over and above the nuisance ...Show More
Episode 392: Aspirin – two more large and maybe unnecessary trials

0:00 | Sep 6th, 2018

In episode 392, James and Mike get back to work after a European tour and other reasons. We go over the results from the latest large aspirin trials and, low and behold, the results show pretty much what we already knew.  Show notes
Episode 390: A shared-decision is the only outcome that matters in EBP

0:00 | Jul 25th, 2018

In episode 390, James and Mike have a discussion about how a shared-decision may be the only real outcome to measure if one is doing, or evaluating, evidence-based practice. Do our arguments convince you? Have we missed something important? Is this t...Show More
Episode 389: Is that cabbage in your bra?

0:00 | Jul 4th, 2018

In episode 389, Mike and James go over with Adrienne Lindblad the evidence for a simple treatment for beast engorgement. Who knew that cabbage leaves worked for breast engorgement? At the end of the podcast we decide to attach cabbage leaves to all o...Show More
Episode 388: Smell This: Isopropyl alcohol for nausea/vomiting

0:00 | Jun 30th, 2018

In episode 388, Mike and James go over with Adrienne Lindblad the evidence for a simple treatment for nausea and vomiting in the ER. Who knew that inhaling isopropyl alcohol worked for nausea and vomiting? – possibly as good as the medications we hav...Show More
Episode 387: Nerve-ous about opioids?

0:00 | Jun 20th, 2018

In episode 387, Mike and James go over the best available evidence for opioids in neuropathic pain. As with many pain treatments the evidence suggests there is some benefit and also some harm.  Overall, it seems a reasonable approach would be to only...Show More
Episode 386: Low fat, low carbs, low evidence

0:00 | Jun 5th, 2018

In episode 386, James and Mike talk about the latest low fat low carb weight loss study and then put it all into context of the more global evidence for low carbs vs low fats.
Episode 385: Talking about stem cell therapies with Tim Caulfield

0:00 | May 28th, 2018

In episode 385, James and Mike invite Tim Caulfield (author, professor and lawyer) yet again to talk about the marketing and evidence around stem cell therapies. Low and behold the evidence pales in comparison to the hype. At the end Tim states – “sc...Show More
Episode 384: Talking about personalized medicine with Tim Caulfield

0:00 | May 25th, 2018

In episode 384, James and Mike invite Tim Caulfield (author, professor and lawyer) to talk about the marketing of personalized medicine. We find out that most of the marketing is absurd. We also figure out that personalized medicine is being done all...Show More
Episode 382: Poverty – the impact it has on health and what we can do about it – PART II

0:00 | Apr 25th, 2018

In episode 382, Mike and James and Gary Bloch decide to try to solve the problem of poverty. While we get somewhere, it becomes clear that it might take more than just doing a 30-minute podcast. Who would have thought? Nonetheless, we hope that some ...Show More
Episode 382: Poverty – the impact it has on health and what we can do about it – PART II

0:00 | Apr 25th, 2018

In episode 382, Mike and James and Gary Bloch decide to try to solve the problem of poverty. While we get somewhere, it becomes clear that it might take more than just doing a 30-minute podcast. Who would have thought? Nonetheless, we hope that some ...Show More
Episode 381: Poverty – the impact it has on health and what we can do about it

0:00 | Apr 18th, 2018

In episode 381, Mike and James invite Gary Bloch to talk in detail about the impact of poverty on health, and more importantly what can we do about it for our patients. In particular, we start to discuss a very useful clinical tool for dealing with p...Show More
Episode 381: Poverty – the impact it has on health and what we can do about it

0:00 | Apr 18th, 2018

In episode 381, Mike and James invite Gary Bloch to talk in detail about the impact of poverty on health, and more importantly what can we do about it for our patients. In particular, we start to discuss a very useful clinical tool for dealing with p...Show More
Episode 380: Happy 10th Anniversary and a bunch of silly studies

0:00 | Apr 16th, 2018

In episode 380, James and Mike continue celebrating their 10th podcasting anniversary with Tina K and Mike K and the silly studies and confusion continue to escalate. Show notes 1) A randomized trial to assess the potential of different beverages to ...Show More
Episode 380: Happy 10th Anniversary and a bunch of silly studies

0:00 | Apr 16th, 2018

In episode 380, James and Mike continue celebrating their 10th podcasting anniversary with Tina K and Mike K and the silly studies and confusion continue to escalate. Show notes 1) A randomized trial to assess the potential of different beverages to ...Show More
Episode 379: Happy 10th Anniversary and a bunch of silly studies

0:00 | Apr 10th, 2018

In episode 379, James and Mike celebrate their 10th podcasting anniversary and bring in Tina K and Mike K to help alert the listeners to some exceedingly important studies that many listeners may have missed over the years. Show notes 1) Beano and fl...Show More
Episode 379: Happy 10th Anniversary and a bunch of silly studies

0:00 | Apr 10th, 2018

In episode 379, James and Mike celebrate their 10th podcasting anniversary and bring in Tina K and Mike K to help alert the listeners to some exceedingly important studies that many listeners may have missed over the years. Show notes 1) Beano and fl...Show More
Episode 378: Antidepressants - lots of useful data but many important questions remain

0:00 | Mar 28th, 2018

In episode 378, James, Tina and Mike go over the latest antidepressant meta-analysis from the Lancet. We talk about the fact that antidepressants do work, but importantly, what does “work” mean. Most importantly, we talk about what questions about an...Show More
Episode 377: Getting higher than a kite with medical cannabinoid evidence – PART IV

0:00 | Mar 19th, 2018

In episode 377, Mike and James finally get to the end of looking at all the available cannabinoid evidence and we continue to discuss how the evidence could be used in the context of a shared-decision making process. Show notes Simplified guideline f...Show More
Episode 376: Getting higher than a kite with medical cannabinoid evidence – PART III

0:00 | Mar 15th, 2018

In episode 376, Mike and James take all the best available evidence around cannabinoid use and put the evidence into the concept of a shared-decision making guideline. Shocking as it may seem, shared-decision making is rarely a part of most guideline...Show More
Episode 375: Getting higher than a kite with medical cannabinoid evidence – PART II

0:00 | Feb 27th, 2018

In episode 375, Mike and James continue getting high on the evidence around medical cannabinoids. We talk about the adverse effects associated with medical cannabinoids and find out it is fairly impressive in not only the number of patients who get t...Show More
Episode 374: Getting higher than a kite with medical cannabinoid evidence

0:00 | Feb 23rd, 2018

In episode 374, Mike and James get high by delving into a systematic review of medical cannabinoids. We put a flame to the evidence, munch on all the data and get the giggles around what the evidence actually shows. The bottom line is, there is evide...Show More
Episode 366: Social determinants of health – why you need to hear this evidence - PART II

0:00 | Nov 24th, 2017

In episode 366, Mike, James, and Tony continue to talk about the very important and broad topic of social determinants of health. Interestingly, evidence is fairly clear that social spending may be more useful to health than health spending and we ne...Show More
Episode 365: Social determinants of health – why you need to hear this evidence

0:00 | Nov 14th, 2017

In episode 365, Mike and James invite Tony Nickonchuk to talk about the very important and broad topic of social determinants of health. We find when it comes to what makes us sick, approximately 75% of our health issues happen to our patients and us...Show More
Episode 364: Depression in primary care – talk first and prescribe later – PART III

0:00 | Nov 2nd, 2017

In episode 364, James, Mike, and primarily Bruce talk about an approach - Focussed Acceptance and Commitment Therapy (FACT) - that clinicians in primary care can use across a broad range of psychological problems. This type of 15-20 minute approach h...Show More
Episode 363: Depression in primary care – talk first and prescribe later – PART II

0:00 | Oct 24th, 2017

In episode 363, James, Mike, Bruce and Helena continue to talk about depression in primary care. The key messages are that instead of calling it depression we should consider telling people they are “stuck”, negotiate non drug therapies like behaviou...Show More
Episode 362: Depression in primary care – talk first and prescribe later

0:00 | Oct 12th, 2017

In episode 362, James and Mike invite Bruce Arroll back to talk about his latest systematic review on antidepressants for treatment of depression in primary care. We quickly come to the realization that primary care is different than specialty care a...Show More
Episode 360: Agitation and aggression in the elderly – PART III

0:00 | Sep 25th, 2017

In episode 360, Mike and James finally get to the end of their agitating three part series on treating agitation in dementia. In this episode we talk about the evidence for the non-drug treatments like group or individual activities, music therapy an...Show More
Episode 359: Agitation and aggression in the elderly – PART II

0:00 | Sep 13th, 2017

In episode 359, Mike and James continue to agitate over the evidence for treating agitation in dementia. We talk about the use of benzodiazepines, antidepressants cholinesterase inhibitors for this difficult to treat condition. The evidence ends up j...Show More
Episode 358: Agitation and aggression in the elderly

0:00 | Sep 5th, 2017

In episode 358, Mike and James in an agitated and demented way deal with the evidence around agitation in dementia. We find that the antipsychotics have an effect that might be noticeable in 1 in 10 people but if a person responds it likely had nothi...Show More