podcast cover

Smart Drug Smarts: Brain Optimization | Nootropics | Neuroscience

Jesse Lawler: Brain Enthusiast, Biohacker, Nootropics Nerd, Multichannel Eccentric

+15 FANS
"Intelligence is as fixed as a person's height." Right? But guess what - you're part of the species that invented platform shoes, stilts, elevators, helium balloons and rocket ships. Smart Drug Smarts is for people interested in maximizing their...Show More
#002: Dr. Carol Greenwood on Brain Nutrition

32:05 | Dec 7th, 2012

Carol explains how she took her understanding of diet's interaction with the brain and worked with professional recipe developers to create meals that your neurons will love as much as your taste buds.
#230: Measuring Intuition with Dr. Joel Pearson

36:44 | Jun 29th, 2018

Some aspects of our internal mental life seem to defy measurement. "Intuition" seems like a prime example of something impossible to quantify... But what if it's not? Dr. Joel Pearson tells us about his ingenious studies putting a value on human in...Show More
#229: Learning to Learn

49:53 | Jun 8th, 2018

Last-minute cramming (even on lots of nootropics) isn't the best gameplan for effective learning. So what is? Learning researchers explain the theory and practice of efficiently building your mental toolkit.
#228: Perception as a Controlled Hallucination

44:34 | May 29th, 2018

Our senses provide us with a best-guess interpretation of reality -- but it's only a guess. Dr. Anil Seth explains how perception and consciousness interact, and how we can intentionally shift our "reality filter" with methods like induced synesthes...Show More
#227: How Language Affects Thought

45:43 | May 14th, 2018

Is "a rose by any other name" still a rose... to your brain? Dr. Viorica Marian explains how the language that we use affects how we actually think.
#226: The Return of Metabolism

50:01 | May 5th, 2018

You don't think much about your electricity until the power goes out. And human metabolism is kind of the same way. Dr. Navdeep Chandel explains why metabolism is worth paying attention to -- for lifespan, healthspan, and for dodging disease.
#225: Schizophrenia with Dr. Tyrone Cannon

52:38 | Apr 21st, 2018

"Schizophrenia" is a word that strikes fear in the hearts (and minds) of those who have seen its effects. It's often misunderstood -- but one aspect that's universally recognized is that it's a *big deal.* And it affects nearly 1% of the adult popul...Show More
#224: Don’t forget about Prospective Memory

47:28 | Apr 10th, 2018

Prospective Memory is something we notice most when it fails -- when we recall (too late!) something we meant to remember. Dr. Michael Scullin tells us how to keep ideas top-of-mind.
#223: Ketone Esters with Dr. Brianna Stubbs

56:46 | Mar 30th, 2018

Ketogenic Diets, Ketone Salts, Ketone Esters... What does all this mean -- and which ones will help turn your brain into a well-lubricated fat-burning engine most easily? Dr. Brianna Stubbs -- who is a biohacker and world-class athlete as well as a ...Show More
#222: What are “Fast-Spiking Interneurons”?

39:03 | Mar 23rd, 2018

What are "interneurons" and how do they affect our brains' ability to function, to change, and to learn? Research scientist Dr. Scott Owen explains the latest findings.
#221: Marijuana, the Non-Medical Kind ;)

1:04:06 | Mar 9th, 2018

It's easier to smoke marijuana legally these days than it is to study it. Strange, but true. But with tens of millions of Americans using recreational marijuana regularly...isn't it time we learned what it's doing to our brains?
#220: Cognitive Fallacies with Dr. Richard E. Nisbett

48:40 | Mar 3rd, 2018

Social scientists have built up a wealth of knowledge about the ways the human brain reliably gets things wrong. Luckily for us - if we stay conscientious, we can work around our built-in bugs.
#219: Aphantasia with Dr. Joel Pearson

36:18 | Feb 17th, 2018

Some people's minds don't come equipped with a "mind's eye." We call these people aphantasics -- and there are many millions of them. And they get by just fine.
#218: Oxytocin, Love and Social Awareness

49:52 | Feb 10th, 2018

For our special Valentine's Episode, we look at the hormone Oxytocin...sometimes called "the love molecule" -- although as you'll hear, it does much more than *just* that.
#217: Fighting Migraines with Dr. Sid Kapoor

42:25 | Feb 3rd, 2018

Sometimes the brain can seem like it has a "self-destruct" button. Migraine headaches and epilepsy are two such examples.
#216: Music and Creativity with Dr. Psyche Loui

39:25 | Jan 27th, 2018

Music, maybe second only to language, seems to be one of the defining characteristics of the human brain -- and an abiding interest for all known human cultures. And it turns out to be both a read/write interface.
#215: Social Illusions with Dr. Erica Boothby

39:12 | Jan 19th, 2018

Optical Illusions are interesting "glitches." But social illusions -- and there are MANY -- actually drive our behavior. Dr. Erica Boothby pulls back the veil on your own inner thoughts.
#214: Ibogaine with Dr. Emeline Maillet

44:05 | Jan 12th, 2018

Ibogaine could be an effective therapy against addiction -- or it could be (literally) the cure that kills the patient. Hear about the many facets of this plant-derived substance from Dr. Emeline Maillet.
#213: Sleep Deprivation with Dr. Paul Whitney

49:06 | Jan 5th, 2018

As biological imperatives go, sleep is the one we need less than air and water, but more than food and sex. Try to get by without it, and the problems start cropping up - fast.
#212: Multi-Lingual Brains with Dr. Ellen Bialystok

36:11 | Dec 30th, 2017

Conventional wisdom holds that knowing more languages is "good for your brain." But what makes it so? And good in which ways? Dr. Ellen Bialystok is one of the world's foremost experts, and conducted many of the studies that has brought this "comm...Show More
#211: MDMA vs. PTSD

40:46 | Dec 23rd, 2017

The FDA has given a green light to a Phase 3 trial using MDMA as a psychologist-assisted therapy against PTSD. How might this "party drug" work in a non-party context?
#210: Mind Wandering

38:47 | Dec 16th, 2017

Mind wandering is bad if you're operating a chain saw. But if you're stuck on a well-defined intellectual problem, it could be just the ticket. Christine Godwin explains the latest research in...um...what was I just talking about?
#209: Addiction – Old and New Schools

1:03:57 | Dec 9th, 2017

Can you be "addicted to Facebook"? And if so, is that much like being addicted to heroin? Two addiction researchers specializing in pharmacology and cyberpsychology weigh in.
#208: Optimizing Epigenetics with Dr. Daniel Stickler

46:13 | Dec 2nd, 2017

If genes are the "Book of You," then epigenetics are the dog-eared pages marking the parts you're interested in right now. Dr. Daniel Stickler explains how to use this active overlay on genetic information to your advantage.
#207: Bugs on Drugs

46:21 | Nov 18th, 2017

Giving LSD to fruit flies sounds like a fraternity prank. But with the right tools, it could be an approach that helps unlock the brain's secrets in perception, mood, and even consciousness.
#206: Ayahuasca vs. Depression with Dr. Draulio Araujo

58:46 | Nov 11th, 2017

Ayahuasca may mark the first time that a nausea-inducing beverage has gotten...popular. But there may be valid medical reasons why "Mother" Ayahuasca -- a brew featuring strong psychedelic effects -- is becoming well known outside the Brazilian jung...Show More
#205: Ambien Off-Label

30:52 | Nov 4th, 2017

Ambien is a well-known sleep aid, with over 40 million annual prescriptions in the US alone. It is not, however, a one-trick pony. Dr. Nick Bomalaski describes his review of numerous odd (and encouraging) examples of Ambien's effects on various neu...Show More
#204: The Sense of Dread

44:27 | Oct 27th, 2017

A real-life scary story for Halloween: How nine healthy young hikers died suddenly, tragically, and mysteriously in 1959 in the Ural Mountains of Russia -- spawning five decades of questions and theories.
#203: Moringa with Dr. Jed Fahey

37:24 | Oct 20th, 2017

Moringa is a tropical tree that looks like it was designed by Dr. Seuss... But it yields leaves so nutrient-rich, it's hard to believe it's not better known. Dr. Jed Fahey explains.
#202: What is Neurogastronomy?

51:55 | Oct 13th, 2017

Neurogastronomy is the most intellectual way to be a foodie. How do we taste and smell? And could scientists manipulate our taste to make brussels sprouts taste like cotton candy and vice versa?
#201: The Cognito Awards, Part 2

36:13 | Oct 8th, 2017

The Cognito Awards continue, with Best Physical Vitality Hack, Best Performance by Technological Gear, and more!
#200: The Cognito Awards

39:29 | Sep 30th, 2017

We celebrate our 200th episode by looking back at some high points of past Smart Drug Smarts episodes in an award-show format: the "Cognito Awards."
#199: The MIND Diet with Dr. Martha Morris

44:26 | Sep 23rd, 2017

The "MIND Diet" makes a strong claim in its very name. Is it the best nutritional strategy to prevent the onset of Alzheimer's Disease? Dr. Martha Morris explains.
#198: Wisdom and Risky Teens with Dr. Dan Romer

43:13 | Sep 15th, 2017

Teens take risks. But they're not "just plain stupid." And according to Dr. Dan Romer - facing off against conventional wisdom and neuroscientific consensus - the risks they take may be "the right risks" to prepare for adulthood.
#197: Metacognition with Dr. Stephen Fleming

43:55 | Sep 8th, 2017

Without the ability to think about thinking, how would you know if you're even thinking right? If the brain is the command center for the body, then metacognition is the control system for the command center.
#196: Psychedelics vs. Inflammation with Dr. Charles Nichols

47:17 | Sep 2nd, 2017

You wouldn't think to take LSD to fight atherosclerosis. But - strange though it may seem - psychedelic compounds may have still more hidden surprises: Powerful anti-inflammation properties that, in mice at least, show effects at psychologically inv...Show More
#195: Dognition

56:47 | Aug 26th, 2017

Domestication has changed ancestral wolves into hundreds of breeds of modern dogs. What has happened to their brains along the way? Meet the only purebred brains in the animal kingdom.
#194: Brain Implants – Medical and Beyond with Dr. Brett Wingeier

45:12 | Aug 19th, 2017

You've got to have a pretty good reason to open your skull on purpose. Dr. Brett Wingeier designs such reasons.
#193: How Far Will Expertise Go?

44:33 | Aug 12th, 2017

We know experts "make it look easy." What we want to know is how they got that way - and how we can too. And, for what it's worth, how easy are nearby domains for experts in a given field?
#192: Testosterone vs. Alzheimer’s

46:34 | Aug 5th, 2017

Alzheimer's Disease and male virility aren't often thought of together, but most people don't consider this a clue to preventing the much-feared disease. Maybe we should. Dr. Ralph Martins explains.
#191: Finding Your Place with Dr. Mayank Mehta

45:22 | Jul 29th, 2017

How do you know where you are? How can you sense when you are lost? And what happens when your senses get conflicting info as reality "leaks" through imperfect Virtual Reality environments?
#190: Sulforaphane with Dr. Jed Fahey

43:14 | Jul 21st, 2017

You know broccoli is good for you. The phytochemical Sulforaphane is a key reason -- and it may deserve to be called not just "health food," but an actual medicine.
#189: Head in the Game with Dr. John Sullivan

46:31 | Jul 14th, 2017

Peak physical performance requires peak mental performance. This is obvious, but also easy to forget. Dr. John Sullivan explains how to make the brain and body perfect teammates.
#188: The Pleasure of Novelty

45:38 | Jul 7th, 2017

We have pleasure-inducing chemical systems in our neural pathways dedicated to vision. What gives?
#187: “Structured Water” with Dr. Gerald Pollack

40:42 | Jul 1st, 2017

Steam, Water, Ice: The three classic phases of water are almost as familiar as water itself. So is it conceivable that the substance we know so well has secrets not only hiding in plain sight, but also hiding inside every cell in our body?
#186: The Replication Crisis with Dr. Rolf Zwaan

39:25 | Jun 24th, 2017

If scientific findings can't be replicated, what have we really found? That question is at the root of the "Replication Crisis" dividing the halls of science. Researcher and reform advocate Dr. Rolf Zwaan explains.
#185: Brains in Orbit with Dr. Rachael Seidler

47:18 | Jun 16th, 2017

Being able to understand the impact that space has on our brains and bodies brings space travel closer.
Overdose Edition #6: Acquired Savant Syndrome

32:44 | Jun 15th, 2017

You'd think there's nothing to be said in defense of brain damage. You'd almost be right. But in a few rare cases, "Acquired Savant Syndrome" gives brain-injured people cognitive abilities they never had before.
#184: Theacrine with Dr. Richard Bloomer

30:29 | Jun 9th, 2017

A caffeine - theacrine stack is often recommended as a “starter stack” for nootropics noobies. Here's what you need to know about theacrine.
#183: Evolving Human Performance

40:17 | Jun 2nd, 2017

The Halo Sport is a health and wellness device which uses transcranial Direct Current Stimulation (tDCS) to achieve physical benefits.
#182: The Importance of Memory

43:05 | May 26th, 2017

Memory is not just a curiosity. Memory is central to our existence -- and our ability to predict the future.
#181: The Future of Education

49:38 | May 19th, 2017

Through the large-scale institutionalization of schooling, we’ve had a collective massive impact on our brains.
#180: The Ongoing Opiate Crisis

53:30 | May 13th, 2017

As the number of people addicted to opiates in the US continues to rise, we look at the physical cause of opiate addiction and what we can do to reverse the trend.
#179: Tongkat Ali: Stress Relief for the Modern World

37:36 | May 5th, 2017

Boost your mental energy, libido, and focus with this traditional Malaysian medicine that also treats chronic stress.
#178: The Potential of Virtual Reality

51:14 | May 4th, 2017

Can we get more out of virtual reality than just games? And what's happening in our brains during a virtual experience?
#177: Know Your Neurotransmitters: Acetylcholine

40:51 | Apr 21st, 2017

It’s high time we covered acetylcholine — the most plentiful neurotransmitter in the body.  And our Know Your Neurotransmitters series continues with the best guest possible to talk to us about acetylcholine.
#176: Breaking the Psychedelic Research Logjam with Dr. David Nichols

53:24 | Apr 14th, 2017

Psychedelics are endlessly fascinating: the preliminary research shows so many therapeutic benefits -- yet there’s so much we still don’t know.
#175: Sleep, Light, and Your Brain

57:09 | Apr 8th, 2017

We know about the detrimental effects of light on our sleep -- but how we can harness light in a positive way, for alertness, mood, and our Circadian rhythms?
#174: There’s Something About Sarcasm…

39:26 | Mar 31st, 2017

Sarcasm can the foundation of misunderstanding but maybe there’s something about sarcasm that can connect us to the power of creativity.
Overdose Edition #5: Reading and Rose-Colored Glasses: The Irlen Syndrome

33:25 | Mar 31st, 2017

Bad vision isn't all in the eye of the beholder: Sometimes it's in the brain. In this Overdose Edition, Helen Irlen describes the Meares-Irlen Syndrome, a neurological disorder she says makes visual processing unnecessarily difficult for millions of ...Show More
#173: When Fish Oil Goes Bad…

33:18 | Mar 24th, 2017

There's long been a misconception that you can "fish oil" a bad diet away. Not only is that idea wrong -- according to Chris Kresser, it can lead to dangerous and unanticipated oxidative stress.
#172: Alcohol Use and Abuse

45:44 | Mar 17th, 2017

Social lubricant. Addictive evil. Between these extremes there’s a sea of alcohol.
#171: Non-Ordinary States of Consciousness

58:34 | Mar 11th, 2017

Jesse talks to the authors of the new book "Stealing Fire" about the widespread use of altered states (achieved through many different means) to achieve heightened performance.
#170: Human vs. Animal Brains

43:15 | Mar 4th, 2017

What makes human brains special? How do animal brains compare to our own?
Overdose Edition #4: The Ōura Ring

29:53 | Mar 1st, 2017

The Oura ring has moved from a Kickstarter concept to a major tool for sleep and recovery research.
#169: The Future of Personalized Medicine

47:21 | Feb 25th, 2017

Our complex biology requires complex, personalized medicine.
#168: Marijuana and the Aging Brain

40:44 | Feb 17th, 2017

Marijuana isn't the first thing you think of to fight off aging. But studies hint that low-dose cannabinoids might be just the thing to protect against brain inflammation.
#167: GABA: the Forgotten Neurotransmitter?

35:41 | Feb 10th, 2017

GABA is crucial for stability in the brain. Supplementing with passion flower is one of the best methods of promoting GABA.
#166: Omega-6 Fatty Acids with Dr. Chris Masterjohn

40:17 | Feb 4th, 2017

Omega-6 fatty acids are both essential and misunderstood -- occasionally even demonized as a too-prevalent part of the Standard American Diet. Dr. Chris Masterjohn explains the role they fill in the human diet, and against-the-grain advice on how to...Show More
#165: Much Ado About Kratom

36:53 | Jan 28th, 2017

What's all the fuss about this Southeast Asian plant that is both a stimulant and an opioid?
#164: Placebo: the Power of the Mind to Heal

45:17 | Jan 20th, 2017

The mind is a powerful thing -- it can heal the body or harm the body.
#163: Idebenone with Dr. Dominic D’Agostino

37:50 | Jan 14th, 2017

Idebenone, CoQ10, ubiquinol... what’s the difference?
#162: The “Gut-Brain Axis” with Scott Anderson

47:30 | Jan 6th, 2017

Han Solo joked that Chewbacca was "always thinking with his stomach."  Science has shown this to be truer than we ever suspected.
#161: Brain Repair and Regeneration

30:46 | Dec 31st, 2016

We’re fascinated by the science behind brain tissue regeneration.
#160: All About Food Addiction

56:13 | Dec 24th, 2016

We need food to survive. Can we really be "addicted" to something required for survival?
#159: Music: By the Brain and For the Brain

57:08 | Dec 17th, 2016

Music is something beloved of people everywhere -- or at least, 98% of them (no joke - details within). Not surprisingly, music can provoke complex brain responses, both in terms of short term emotion and long-term learning and perceptual awareness....Show More
#158: You Got It From Your Mama: Intelligence & Genetics

46:12 | Dec 10th, 2016

When it comes to intelligence, which is more important: nature or nurture?
#157: Vitex with Matt Legge

30:01 | Dec 2nd, 2016

Vitex will boost your mood, give you more energy, and cure your man boobs.
#156: Lead Toxicity with Dr. David Bellinger

45:49 | Nov 25th, 2016

Jesse talks with Dr. David Bellinger about the mechanisms by which lead lowers IQ, and the challenges (and opportunities) of finding a lasting solution to environmental lead exposure.
#155: Microdosing LSD with Dr. James Fadiman

50:42 | Nov 19th, 2016

Here’s why psychedelics aren’t just a hippy phenomenon.
#154: Rethinking Addiction With Maia Szalavitz

38:30 | Nov 11th, 2016

Are addicts just greedy, selfish people who want more pleasure than everyone else? It's time to rethink addiction.
#153: Low-Dose Lithium: a Hidden Panacea?

35:05 | Nov 5th, 2016

Lithium has long been a standard treatment for mania and Bipolar Disorder. But this might be only the tip of an iceberg of usefulness to human brains and bodies. Dr. De-Maw Chuang explains.
#152: Traumatic Injuries and Your Brain

42:07 | Oct 29th, 2016

It's a two-for-one: Dr. Martin Monti and Dr. Kathleen Bell talk to us about the nature of traumatic brain injuries, when it’s a "no brainer" to go see a doctor, and how to create a brain resilient to injury.
#151: Can White Noise Help You Focus?

34:02 | Oct 21st, 2016

Where do you go to get focused work done? Library? Busy coffee shop? Noisy environments are actually better for focus, but only for certain people.
#150: Plant Toxins and the Neurons Who Love Them

41:24 | Oct 15th, 2016

You probably ate something toxic today. But don’t panic! It was actually good for you.
#149: Kava: from Ceremonial Drink to Modern Mood-Booster

28:48 | Oct 7th, 2016

Kava, a traditional Polynesian drink, has a host of benefits: it's relaxing, a mood booster, and relieves pain.
#148: Know Your Neurotransmitters: Oxytocin

40:30 | Sep 30th, 2016

Everyone calls oxytocin the "love hormone," but it’s more accurate to call it the trust, bonding, and sociability hormone. And that’s not all it does.
#147: Ketosis and Your Brain

1:09:13 | Sep 23rd, 2016

Remember when carbs were good and fat was evil? Now, not so much. Here's why (and how) you should try ketosis.
#146: Nicotine: Pure Evil or Brain Fuel?

41:18 | Sep 16th, 2016

Do you think nicotine is evil? Well, think again. Dr. Grunberg is back to tell us more about the cognitive enhancing properties of nicotine.
#145: Dennis McKenna: A 30-Year Psychedelic Education

58:56 | Sep 9th, 2016

Let’s go on a trip with psychedelics expert (and brother of Terence McKenna ) Dr. Dennis McKenna.
#144: Getting to Know Alpha-GPC

32:51 | Sep 3rd, 2016

Alpha-GPC is an essential precursor to the neurotransmitter acetylcholine, responsible for focus, learning, and memory.
#142: What Gratitude Can Do For Your Brain

43:44 | Aug 19th, 2016

Practicing gratitude isn't just for hippies. Science shows real, concrete health and cognitive benefits from being grateful.
#141: Hypnosis: When Imagination Takes Control

42:14 | Aug 12th, 2016

If you think hypnosis is all about swinging watches, have we got news for you. It can change the way we use our brains in ways that were previously thought impossible.
#140: Melatonin, Sleep, and Your Pineal Gland

40:29 | Aug 5th, 2016

Dr. Richard Wurtman is back to explain the mysteries of the pineal gland, melatonin, and sleep onset.
#139: Boost Your Brain with Blueberries

41:56 | Jul 29th, 2016

Blueberries really are a superfood: they improve long-term and short-term memory. Dr. Krikorian explains the whys, hows, and how muchs of blueberries.
#138: How Reliable is fMRI Data?

38:50 | Jul 22nd, 2016

fMRI sounds pretty scientific, right? But it turns out that plenty of scientific results, backed by fMRI data, may be unreliable.
#137: DMT: Dr. Rick Strassman’s Breakthrough Work With “The Spirit Molecule”

56:00 | Jul 15th, 2016

Dr. Rick Strassman is something of a legend in the psychedelic research community. His studies in the early 1990s re-opened a door which had been securely bolted for almost three decades: a prohibition against testing psychedelics on human research ...Show More
Overdose Edition #3: The Flynn Effect: Smarter by the Decade

17:24 | Jul 13th, 2016

Apologies for the ultra-brief post, but we wanted to get this Overdose Edition up quickly… The Flynn Effect is a strange-but-true revelation.  Over the course of the 20th century — and apparently continuing still — “average” people in countries aroun...Show More
#136: The Wahls Protocol: Fighting Fatigue With a Fork

38:29 | Jul 8th, 2016

Dr. Terry Wahls talks functional medicine, ketosis, and implementing the Wahls Protocol in practice.
#135: Treating Depression with Ketamine

38:39 | Jul 1st, 2016

Ketamine has quite the reputation as a club drug. But research is showing its promising potential as a treatment for severe cases of depression.
#134: Rapamycin: The Real Deal Anti-Aging Pill?

44:32 | Jun 24th, 2016

Rapamycin, derived from bacterium found on Easter Island, could help you live longer. Dr. Kaeberlein explains the science behind rapamycin, and how he's using it to help man's best friend live longer.
#133: Ginseng with Dr. Andrew Scholey

37:01 | Jun 17th, 2016

Dr. Andrew Scholey talks to us about his research on Ginseng, including the optimal dose and ways in which Ginseng out-performs Modafinil.
#132: Obesity and Memory with Dr. Lucy Cheke

52:13 | Jun 10th, 2016

Jesse talks to Dr. Lucy Cheke about the memory-imparing consequences of obesity.
#131: Fighting Alzheimer’s with Dr. Richard Wurtman

36:00 | Jun 3rd, 2016

Jesse talks to Dr. Richard Wurtman about Souvenaid, a new medical food that seems to slow the progression of Alzheimer's Disease.
#130: Chocolate and Cognition with Dr. Georgina Crichton

23:57 | May 27th, 2016

Good news for chocoholics: People who eat a small amount of chocolate at least once a week perform better cognitively.
#129: LSD With Dr. Robin Carhart-Harris

46:18 | May 20th, 2016

Jesse talks with Dr. Carhart-Harris about the prototypical psychedelic, LSD, how it changes the brain in long-lasting ways, and why you'll never look at bicycles the same way again.
#128: Expertise With Dr. Karl Anders Ericsson

41:59 | May 13th, 2016

We’ve all heard of the 10,000 Hour Rule, but what about deliberate practice? Dr. Ericsson talks us through becoming an expert through deliberate practice, including visualization, finding a mentor, and more.
#127: Building Better Baby Brains

37:39 | May 6th, 2016

More intelligence is "lost" to inadequate fetal nutrition than to anything else, period. In this special Mother's Day episode, Jesse speaks with Dr. Kavitha Menon about the greatest dangers to the development of baby brains, in both the developing a...Show More
#126: Bacopa Monnieri With Professor Con Stough

29:30 | Apr 29th, 2016

In episode 126, Professor Con Stough talks to Jesse about Bacopa, the oldest herbal medicine in the world. A powerful memory enhancer that promotes synaptogenesis, this is one herb you'll want to want to add to your medicine cabinet, regardless of y...Show More
#125: Exercise and Cognition

48:58 | Apr 22nd, 2016

Brains and Brawn, long positioned as polar opposites, turn out to be anything but. In this episode, Jesse talks with fitness trainer Sal di Stefano -- also the co-host and resident science geek at the MindPump podcast -- about best practices to use ...Show More
#124: Cannabidiol: THC’s Legal Sibling

42:27 | Apr 15th, 2016

Compounds in the hemp plant are so potent within the human body that an entire class of naturally-occurring molecules inside humans (the "endocannabinoids") are named after the plant -- ​not the other way around! In Episode 124, Jesse interviews ath...Show More
#123: Has Dr. Michael Graziano “Solved” Consciousness?

43:11 | Apr 8th, 2016

In his book "Consciousness and the Social Brain," Princeton neuroscientist Dr. Michael Graziano lays out his compelling Attention-Schema Theory. Has he solved the "Hard Problem" of Consciousness?
#122: Experimental Chakra Transplants

29:27 | Apr 1st, 2016

Dr. Andreet Mankala is the creator and leading advocate for one of the most cutting-edge medical procedures being performed today. At least, that's what her proponents say. Others are not so sure, pointing out that her experimental chakra transplanta...Show More
#121: Supplement Quality Assurance

34:45 | Mar 25th, 2016

LabDoor's goal is full-spectrum testing of the majority of consumer supplements -- upwards of 10,000 different products. One piece of their innovative approach is to have users vote on what category of supplements gets added to their next battery of ...Show More
#120: Intermittent Fasting and Cognition with Dr. Mark Mattson

42:24 | Mar 18th, 2016

Dr. Mark Mattson, neurologist at Johns Hopkins University and the National Institute of Health (NIH), has decades of work in the fields of nutrition, brain health, and the complex interplay between diet, exercise, "feeding windows," and macronutrient...Show More
#119: The Ethics of Amplified Intelligence

46:27 | Mar 12th, 2016

As the popularity of smart drugs and cognitive enhancement technologies becomes more widespread, questions of ethics and fairness rise to the surface. We remember that along with the scientific question of "can we" is the ethical sibling question "sh...Show More
#118: Turmeric: Spice for your Brain

45:40 | Mar 5th, 2016

The adaptogen plant turmeric has been a mainstay of Indian and Asian cooking for millenia. Its root is chock-full of bioactive curcuminoid compounds that have been shown to provide wide-ranging benefits from the reduction of oxidative stress to the ...Show More
Overdose Edition #2: “Brain, Meet Lymphatic System” – A Biology Surprise

18:16 | Feb 29th, 2016

"Textbooks are going to need to change." That was the general consensus around the 2015 discovery that previously unknown lymphatic vessels connect the brain directly to the immune system. Hear about the breakthrough discovery from co-discoverer Pro...Show More
#117: Kara Platoni’s “We Have the Technology”

50:27 | Feb 27th, 2016

"Grinders" take their stylistic queues from piercing shops, tattoo parlors and custom auto mechanics -- combining skills in electrical circuitry and biology to leap past "wearable" technology straight into integrated doodads like an LED compass that ...Show More
#116: Psilocybin and the Potential for “Psychedelic Therapies”

36:44 | Feb 19th, 2016

Dr. Frederick Barrett discusses recent and upcoming studies into psilocybin -- the psychoactive ingredient that puts the "magic" in magic mushrooms.  This currently "Schedule 1" drug, in addition to reasonably reliably provoking mystical experiences ...Show More
#115: Collaborative Recall

39:19 | Feb 12th, 2016

There are times when social remembering can make our memories less accurate.  However, by following the right strategies when remembering together -- creating a sort of "extended mind" -- we can improve our recall, particularly if those doing the rem...Show More
#114: Modern AlkaMe + Personalized Neuroscience

30:11 | Feb 6th, 2016

Is there a scalable way for people to benefit from others' experience without having to comb through Reddit threads and best-guess which writers' stories applied to them? Garrett Ruhland's search for a solution led to the formation of his company, ...Show More
#113: Porn Addiction and the Brain

50:31 | Jan 30th, 2016

The fallout from porn addiction goes beyond sexual dysfunction -- way beyond. The brain's dopamine system is the major motivational system for everything we do. Desensitizing it with surging arousal from porn can cause the brain to lower its overall...Show More
#112: Strange Bedfellows: Orthodontics and Neurology

42:01 | Jan 23rd, 2016

Anthony Sims and Gary Demerjian are probably the two leading practicioners of the treatment of neurological conditions with mouth-worn orthodontic appliances -- based on soothing irritated nerves in the jaw to alleviate symptoms throughout the body.
#111: Artificial Intelligence: Promise and Peril

48:42 | Jan 16th, 2016

Jesse speaks with futurist and author Calum Chase about his book Surviving AI, and the increasing impacts of artificial intelligence on business, society, and humanity itself.
#110: Plant Medicines

41:35 | Jan 8th, 2016

Jesse is joined by Dr. Jim Adams from the USC School of Pharmacy for a far-ranging discussion about traditional plant medicines.
#109: Habit

35:47 | Jan 1st, 2016

For our first episode of 2016 we talk about habit formation, the use of external modalities along with ideal ways to implement changes in your habits.
#108: Hormesis

38:56 | Dec 25th, 2015

Get your smartypants ready for our year-end finale as Jesse and Dr. Edward Calabrese dive into the world of Hormesis and dose response thresholds.
#107: Brainwave Entrainment

32:26 | Dec 18th, 2015

Join Jesse and the founders of Brain.fm and explore the science behind audio brainwave training and the potential for its development.
#106: Synesthesia

33:34 | Dec 11th, 2015

Dr. Richard Cytowic joins Jesse this week to demystify Synesthesia and shed some light on this incredible quirk of human evolution.
#105: The Racetam Family

33:07 | Dec 4th, 2015

Whether you’re complete strangers or bosom buddies with the Racetam family, Jesse and Dr. Andrew Hill will make you feel welcome and get you introduced to everybody.
#104: Electroceuticals

43:56 | Nov 28th, 2015

Join Jesse and Prof. Vincent Clark for a spirited discussion about the emerging field of electroceuticals and magnetoceuticals.
#103: The Gray Market

27:50 | Nov 20th, 2015

Join Jesse & attorney Lawrence Walters for an in-depth look at the gray market for pharmaceuticals - the regulations and risks involved to health and privacy.
#102: Chemical Willpower

30:28 | Nov 13th, 2015

Can "motivational" chemicals reduce people's inherent laziness about exercise, and make them form better health habits? Tune in and find out.
#101: Holotropic Breathwork – Real-world Results

30:05 | Nov 7th, 2015

Jesse and a small cadre of DIY enthusiasts attempt to alter their consciousness through a process known in psychology circles as "Holotropic Breathwork."
#100: Card-carrying Genius

37:29 | Oct 30th, 2015

In episode 100 IQ meters spike up to dangerously high levels, as Jesse is joined by Rick Rosner - who ranks second in The World Genius Directory.
#099: Psychedelics – New Perspective

45:14 | Oct 23rd, 2015

Join Jesse and Brad Burge from MAPS for an engaging discussion about the current state of affairs with psychedelics. Are the winds of change blowing?
#098: Adderall Perspectives

30:40 | Oct 16th, 2015

In episode #98 Jesse throws four prescribed Adderall users into the mix who talk about their experiences with the drug and weigh the pros and cons.
#097: Emotional Intelligence

34:49 | Oct 9th, 2015

Jesse and Prof. Con Stough discuss the emotional aspects of intelligence - recognizing and managing them along with improving your emotional self-awareness.
#096: Know Your Neurotransmitters: Noradrenaline

31:45 | Oct 2nd, 2015

In Chapter 3 of the Know Your Neurotransmitter series Jesse and Prof. Clare Stanford examine Noradrenaline - the lesser-known chemical cousin to Adrenaline.
#095: The Medicalization Of Love

41:19 | Sep 25th, 2015

Brian D. Earp joins Jesse to discuss the possibilities and ethics of making biochemical tweaks to the most celebrated of human emotions - love.
#094: Sparking The Brain

33:41 | Sep 18th, 2015

Jesse and Dr. James Giordano have a spirited conversation about brain stimulation technologies, neuroethics and the importance of experimentation.
#093: Semen – The World’s Sexiest Antidepressant

34:18 | Sep 11th, 2015

Jesse brings evolutionary psychologist Dr. Gordon Gallup on board this week for an in-depth look at semen chemistry and its mood altering effect on females.
#092: Nexus Nitty Gritty

30:20 | Sep 4th, 2015

Join Jesse and abelard Lindsay in a freewheeling discussion about the framework behind the nootropic stack Nexus - a flagship product of Axonlabs.io
#091: Fatigue + Creativity

29:39 | Aug 28th, 2015

What kind of tasks benefit from a mind that’s slightly groggy? Jesse is joined by Mareike Wieth to discuss her research on fatigue and its’ effect on problem-solving skills.
#090: GHB – The Good, The Bad and The Sleepy

42:08 | Aug 21st, 2015

Stay tuned as Jesse and Dan Pardi take a deep dive into the world of GHB - the early years, the potential for benefits and misuse and the subsequent ban.
#089: Holotropic Breathwork – DIY Psychedelia

40:03 | Aug 14th, 2015

Jesse takes a deep dive into the realm of psychedelic therapy and Holotropic Breathwork with Dr. James Eyerman. Take a deep breath and tune in.
#088: Jesse’s Ritalin Self-Experiment

33:27 | Aug 7th, 2015

Jesse takes Ritalin for the first time ever and conducts a single-subject scientific study. What results does the experiment yield? Tune in to find out.
#087: Virtual Reality Therapy

31:00 | Jul 31st, 2015

Virtual Reality Therapy is a method for treating phobias and anxiety; Dr. Robert Reiner has been on the forefront for nearly three decades.
#086: The Pharmacology of Morality

39:21 | Jul 24th, 2015

In this week’s episode Jesse takes a deep dive with Dr. Molly Crockett in to the world of enhancing morality through pharmacological interventions.
#085: Abelard Lindsay and the Story of Mitogen

38:43 | Jul 16th, 2015

Jesse and long-time biohacker and self-professed nootropics geek Abelard Lindsay take a look at how the recently launched Mitogen stack was born.
#084: Optimal Cognition in Extreme Environments

47:30 | Jul 10th, 2015

Jesse is joined by cave-diver-cum-research-scientist Dr. Dawn Kernagis from IHMC (the Florida Institute for Human and Machine Cognition) for a chat about maintaining optimal cognition in extreme environments.
#083: Aniracetam – First of the Ampakines

27:03 | Jul 3rd, 2015

Jesse has an insightful discussion about Aniracetam with Prof. Keith Wesnes responsible for almost 200 clinical trials in a career starting from 1970.
#082: Lion’s Mane Mushroom

39:47 | Jun 27th, 2015

Tune in to our first ever fungal episode where Eric Cerecedes joins Jesse for a wildly interesting conversation about Lion's Mane mushrooms.
#081: Optimizing Your Sleep

36:36 | Jun 19th, 2015

Ex-Navy SEAL Dr. Kirk Parsley joins Jesse this week for a candid discourse on sleep. From the pros and cons of biphasic sleep, to the importance of naps, to Doc Parsley’s personal experiences with sleep-deprived SEALs... This is an episode worth st...Show More
#080: Addiction

33:37 | Jun 12th, 2015

Could a smart drug "habit" be a gateway to addiction? What's the difference between addiction and physical dependence? What's going on with the brain's dopaminergic systems during addictive behavior?
Overdose Edition #1: The First One

30:46 | Jun 11th, 2015

This first-ever Overdose Edition provides not only an interesting interview… We also get to ride side-saddle with professional researcher Drew Birnie, as he talks us through his research methodology, delving into the merits of the claims made about a...Show More
#079: Phosphatidylserine: Extra Oomph, Even For Young Brains

29:18 | Jun 8th, 2015

Want to get more of a cognitive boost out of your workout? "Generally Recognised As Safe" supplement phosphatidylserine could be the answer.
#078: Pine Trees and Pycnogenol

37:02 | May 29th, 2015

This week Jesse and Dr. Jeffry Strong wander into a forest of lesser known plant extracts, discussing Pycnogenol, a product derived from the bark of a unique species of pine trees. Its effects range from anti-oxidation and reduction of inflammation t...Show More
#077: Omega-3 Shoot-Out

36:38 | May 22nd, 2015

A shoot-out between the various types of Omega-3-fatty-acid-containing foods and supplements - from production methods to bio-absorption percentages to dosage, diet and dangers.
#076: The Ethics of Moral Enhancement

35:39 | May 15th, 2015

Jesse has a freewheeling discussion with John Danaher about "moral enhancement" technologies - old and new. They talk about emerging technologies, ethics and the notion that the mind extends much beyond our body and brain.
#075: Creatine: Brains and Brawn?

28:08 | May 8th, 2015

Creatine has long been known as a supplement-of-choice for athletes and weightlifters... but what cognitive benefits might Creatine provide?
#074: Know Your Neurotransmitters: Dopamine

33:05 | May 1st, 2015

Round 2 of the “Know Your Neurotransmitters” series, featuring Professor John Salamone of the University of Connecticut, talking about that most popular neurotransmitter: Dopamine.
#073: Fish Oil: A Cognitive Lubricant?

29:39 | Apr 25th, 2015

Jesse is joined by Dr. Andrew Pipingas and Professor David Crewther for a conversation about fish oil and its effects on neural efficiency, introducing the idea that "smart brains work less hard."
#072: EEG: Lessons From A Half-Million Brains

28:03 | Apr 17th, 2015

We're joined by QEEG Diplomat and founder of Brain Science International Jay Gunkelman to talk Electroencephalography.
#071: Lemon Balm: 2300 Years of “Joy and Mirth”

26:27 | Apr 11th, 2015

Professor Andrew Scholey takes us through the history and effects of adaptogen, and powerful cognitive and mood enhancer Lemon Balm.
#070: Know Your Neurotransmitters: GABA

24:42 | Apr 4th, 2015

For the very first in our "Know Your Neurotransmitters" series, Jesse is joined by Dr. Matthew Broome to talk about the neurotransmitter GABA. Dr. Broome explains how GABA works, where it comes from, and how it affects our brains and bodies.
#069: Ritalin: On and Off-Label

32:28 | Mar 28th, 2015

We welcome back Dr Sunderji to speak to us about Ritalin – the benefits, the risks, and the importance of careful diagnosis and responsible dosing.
#068: Electrified Brains (Experimentation in tDCS)

34:27 | Mar 18th, 2015

Jesse conducts his first tDCS experiment, and is joined by tDCS veteran Chris Zobrist to discuss best practices, mechanisms of action, and results.
#067: Going Beyond The Turing Test

35:21 | Mar 11th, 2015

Dr. Kenneth Ford gives a fresh take on the principles behind the Turing Test, and artificial intelligence, and the hurdles that stand in the way of quicker advancement in the field.
#066: Starvation And Its Benefits

33:09 | Feb 26th, 2015

Dr. Longo shares with us his research on the beneficial effects of fasting on everything from our immune responses to our lifespans, and addresses some points of curiosity that arose over the course of our calorie-free week.
#065: CANTAB: Quantified Cognition

35:45 | Feb 19th, 2015

Professor Trevor Robbins, co-inventor of the Cambridge Neuropsychological Test Automated Battery (CANTAB) – a computer-based cognitive assessment system – explains its use for both neurodegenerative disease detection and cognitive enhancement efficac...Show More
#064: Male vs. Female Brains

37:23 | Feb 12th, 2015

For our Valentine's Day special edition, Dr. Peters explains the basics of what makes male brains male and female brains female.
#063: IARPA – Tax Dollars, Sci-Fi Goals, And Your Brain

38:09 | Feb 5th, 2015

IARPA's Dr. Adam Russell introduces us to the SHARP Program, which aims to uncover the most effective methods to optimize adaptive reasoning and problem-solving in high-performing adults working in cognitively-demanding environments.
#062: Brain Changes From “The Pill”?

23:16 | Jan 28th, 2015

We hear from Dr. Belinda Pletzer about how oral contraception, or "The Pill", may be altering women's brain structures.
#061: In Defense of Marijuana?

29:30 | Jan 21st, 2015

We hear from Kyle Boyar, researcher at SC Laboratories, a quality assurance and safety testing facility for medical marijuana. Kyle takes us through some lesser-known facts about marijuana, its use as treatment for a variety of ailments, and its effe...Show More
#060: Blood Work with Dr. Alexis Shields

31:26 | Jan 15th, 2015

Dr. Alexis Shields, naturopathic doctor and blood chemistry specialist, explains how blood chemistry analysis can be used to monitor and improve overall health, and how the insights we gain can help us maintain optimal neurotransmitter levels and boo...Show More
#059: Lucid Dreaming with Dr. Deirdre Barrett

41:55 | Jan 8th, 2015

Dr. Deirdre Barrett shares with us the ins and outs of lucid dreaming – what it is, how to achieve it, and how we can use it as a cognitive tool.
#058: Neurotoxins: Villains of the Brain

38:24 | Dec 29th, 2014

Dr. David Bellinger explains how neurotoxins in our environment affect our development and tells us how we can best protect our, and our children's, brains.
#057: Rhodiola rosea: “Santa’s Stimulant”

42:15 | Dec 22nd, 2014

Dr. Patricia Gerbarg introduces us to Rhodiola rosea, an herbal supplement used to increase stamina, decrease mental fatigue, and combat stress.
#056: Ketosis vs Cancer?

41:48 | Dec 14th, 2014

In Episode #56, Dr. Thomas N. Seyfried of Boston College stops by to introduce us to his research on cancer as a metabolic disease – not a genetic one. He explains how regular therapeutic fasting can increase mitochondrial respiration, and how calori...Show More
#055: Plant-Based Cognitive Enhancers

33:21 | Dec 6th, 2014

Professor Stough shares with us his research methods and decades of insight into plant-based cognitive enhancers with chronic (ongoing) effects, like Gingko biloba and Bacopa monnieri.
#054: L-tryptophan and Your Holiday Brain

23:58 | Nov 26th, 2014

We're joined by Professor Gilles Guillemin, world leader in research on L-tryptophan and neuroinflammation.
#053: Snakes On A Brain!

25:22 | Nov 22nd, 2014

Jesse speaks to Drew Birnie, Research Scientist and Content Manager at MarkManson.net, about "Snake Oil" – the term used to classify fraudulent medicine, or products that claim unverified results.
#052: Mimicking Caloric Restriction with Oxaloacetate

38:20 | Nov 17th, 2014

Alan Cash, physicist and entrepeneur behind benaGene Advanced Anti-Aging supplement introduces us to oxaloacetate and talks us through its positive CRON (Calorie Restriction with Optimal Nutrition)-mimicking effects.
#051: The Aquatic Origins Of Your Brain

51:27 | Nov 9th, 2014

In Episode #51, Jesse speaks with Dr. Michael A. Crawford of Imperial College London about the role of seafood — and the essential fats they contain — in the evolution, development, and maintenance of our brains. Dr. Crawford shares with us a “coast...Show More
#050: The Pain Episode

26:21 | Oct 30th, 2014

Professor Lorimer Moseley from the University of South Australia shares with us his extensive knowledge on the way our brains process pain.
#049: Sensory Deprivation Tanks

26:48 | Oct 23rd, 2014

Jesse speaks to Crash, owner of Float Lab Technologies, a sensory deprivation tank center in Venice Beach, California. Crash explains the ins and outs of the Float Lab experience, and what can happen to our minds when they're freed from all external ...Show More
#048: 25 Years of Holosync Meditation

28:40 | Oct 8th, 2014

In Episode #48, Jesse interviews Bill Harris, meditation guru, founder of The Centerpointe Research Institute, and creator of Holosync Audio Technology. Bill tells us how we can gain more self-awareness in order to exercise choice in our lives, and h...Show More
#047: Do You Need a Living Autopsy?

21:11 | Sep 29th, 2014

Jesse interviews Dr. Eric Braverman, best-selling author of books The Edge Effect and Younger You, and founder of the PATH Medical Center in New York.
#046: Improving on Piracetam with Noopept

22:54 | Sep 21st, 2014

Dr. Rita Ostrovskaya, world-leading expert and co-creator of Noopept, joins us to shed some light on this new-to-the-scene nootropic.
#045: Axon: an App for the Nootropics Community

20:55 | Aug 31st, 2014

Jesse discusses the soon-to-be-released mobile app Axon, aimed at the nootropics-loving community in general, and Smart Drug Smarts fans in particular.
#044: Do-It-Yourself Transcranial Direct Current Stimulation

23:15 | Aug 12th, 2014

Jesse interviews Nathan Whitmore, creator of the open-source project "OpenBrainStim", an affordable alternative to commercial transcranial Direct Current Stimulation (tDCS) devices.
#043: Is Cognitive Enhancement Ethical?

50:10 | Aug 3rd, 2014

We speak to Dr. Nicole A. Vincent and Dr. Emma A. Jane, co-authors of the article "Put Down the Smart Drugs," on the ethics of cognitive enhancement. Jesse weighs in with his own views on the speculative rights and wrongs of nootropics use.
#042: Nootropics on Wall Street

31:13 | Jul 22nd, 2014

Dr. Andrew Hill joins us to talk about his recent study conducted at the Alternatives Brain Institute, measuring the effects of truBrain on some of the quickest minds on Wall Street.
#041: Daniel Kim-Shapiro on Beetroot Juice and Cognition

26:08 | Jul 8th, 2014

Jesse speaks to Daniel Kim-Shapiro, Director of the Translational Science Center at Wake Forest University and expert on this week’s topic: beetroot juice.
#040: A Nootropics Roundtable

46:58 | Jun 29th, 2014

Jesse and two guests discuss some popular misconceptions about smart drugs, their personal favorite stacks, and other topics surrounding the growing popularity of neurological performance enhancers
#039: Dr. Emily Deans Explains Ketosis

35:55 | Jun 16th, 2014

Dr. Emily Deans Explains Ketones and the State of Ketosis
#038: Dr. Kimberly Urban and the Impact of Nootropics on Neuroplasticity

33:08 | Jun 2nd, 2014

Dr. Urban brings to light facts about how some brain stimulants work (specifically Ritalin), how they were originally tested, and why imperfections in the testing methodologies could spell danger to mis-diagnosed or off-label users.
#037: Dr. David Nutt and the Obstacles to Rational Drug Research

35:38 | May 11th, 2014

Jesse interviews the UK's Dr. David Nutt on the legal and social obstacles surrounding progressive drug research.
#036: Dr. Christopher Winter: Sleep and its Impact on Cognitive Function

35:31 | May 4th, 2014

In episode #36, Jesse interviews Dr. Christopher Winter on the importance of sleep to cognitive function.
#035: Rani Lill Anjum Discusses Causation and Correlation

37:15 | Apr 4th, 2014

Jesse talks with Rani Lill Anjum, of the Norwegian University of Life Science (NMBU) on the difference between causation and correlation.
#034: Dr. Jehangeer Sunderji and the Growing Popularity of Adderall

26:07 | Mar 25th, 2014

Jesse talks with Los Angeles-based physician Dr. Jehangeer Sunderji on the growing popularity and uses of the psycho-stimulant drug Adderall.
#033: Dr. James Wilson on Adrenal Fatigue

35:07 | Mar 14th, 2014

Jesse interviews Dr. James Wilson on the topic of topic of adrenal fatigue.
#032: Dr. Michael Lewis and the Power of Omega-3 Fatty Acids

36:59 | Mar 3rd, 2014

Dr. Michael Lewis discusses the positive impacts Omega-3 fatty acids can have on the health and maintenance of the human brain.
#031: Jason Sada of Axon Sports Discusses the Athletic Brain

31:21 | Feb 20th, 2014

Jason Sada discusses the analysis and training methods employed by Axon Sports to condition the "athletic brain" of elite athletes from around the world.
#030: Dr. Costa-Mattioli and Augmenting Memory Formation

32:01 | Feb 9th, 2014

These findings will lead to the development of treatments for conditions associated with memory loss...and could have big implications for the next generation of smart drugs.
#029: Dan Hurley and the New Science of Building Brain Power

32:41 | Feb 1st, 2014

Dan Hurley's new book Smarter follows his personal investigation into brain-training and the growing number of means now available to people to literally improve their intelligence.
#028: Mark Divine on Mental Toughness and the Navy SEALs

31:08 | Jan 24th, 2014

Mark is the author of several books: 8 Weeks to SEALFIT, Way of the SEAL, and Unbeatable Mind. SEALFIT – a personal-improvement regimen developed by Mark – is uniquely effective at developing elite level physical and mental fitness, helping trainees ...Show More
#027: Dr. Terry Wahls’ Functional-Medicine Diet: The Wahls Protocol

42:47 | Jan 17th, 2014

Dr. Wahls discusses her personal story of recovery from multiple sclerosis, her new book The Wahls Protocol, and the day-to-day choices that can extend your life, maximize your health and fend off the most common degenerative neurological diseases.
#026: Dr. Laura Juliano Discusses Caffeine

36:19 | Jan 10th, 2014

In episode #26, Dr. Juliano speaks with Jesse about the nuances, dangers and benefits of caffeine – the world's most popular and readily-available cognition-enhancing drug.
#025: Dr. J. Lucas Koberda and LORETA Neurofeedback

33:41 | Dec 27th, 2013

Dr. Dr. J. Lucas Koberda discusses the applications and benefits of LORETA Neurofeedback in brain disorders, sports and cognitive optimization.
#024: Dr. Gomez-Pinilla and the Impact of Diet and Exercise on Cognition

35:59 | Dec 18th, 2013

Dr. Gomez-Pinilla's research is to investigate neuronal adaptation to environmental factors like diet -- and how this scales up to the whole-organism level.
#023: Dr. Felipe Fregni and Transcranial Direct Current Stimulation

38:02 | Dec 6th, 2013

Dr. Felipe Fregni, the director of the Laboratory of Neuromodulation and Center of Clinical Research Training, talks about his research into the use and benefits of Transcranial Direct Current Stimulation (tDCS).
#022: Nicotine: The Most Interesting Drug in the World?

49:45 | Nov 6th, 2013

Dr. Neil Grunberg is one of the leading minds in the study of nicotine. He's spent almost thirty years studying the effects of nicotine on the body and brain. In this episode, he shares his wealth of knowledge regarding nicotine, and why he considers...Show More
#021: Abelard Lindsay and Roy Krebs on Long-Term Potentiation

42:10 | Oct 3rd, 2013

This combination of ingredients, says Abelard, provided him with an immediate boost in desire-to-learn, as well as what felt like an ability to learn... And for the past two-plus years, he has been testing and refining what he came to call the "CILTE...Show More
#020: Fabrizio Benedetti and the Placebo Effect

34:19 | Sep 22nd, 2013

As the Placebo Effect relates to nootropics, it's important to recognize that the brain learns the resulting "feel" of nootropics, just like any other drug. You are almost certainly experiencing placebo effects bolstering even your most effective no...Show More
#019: Jesse’s Aniracetam Self-Experiment

27:48 | Jul 20th, 2013

Aniracetam has been reported to yield significant increases in cognitive functioning and abilities. This is further enhanced by its effects on memory recall and, probably more importantly, its high-level effects on learning. To add to that, the drug ...Show More
#018: Testing a Piracetam Hyper-Dose on Experimental Test Subject #2

20:53 | Jun 26th, 2013

"We are on the cutting edge here at Smart Drug Smarts, but I don't think the cutting edge is very sharp because I really don't feel much at all."
#017: Dr. Raza Naqvi’s Review of 32 Published Pharmacological Studies

26:38 | Jun 12th, 2013

Dr. Naqvi advises his patients to get off of as many medications as possible, unless there is a proven upside – and especially if they are already on other medications with which their may be unknown interactions.
#016: Lawrence G. Walters and the Law Surrounding Online Pharmacies

33:10 | May 29th, 2013

Lawrence G. Walters shares insights into the legal aspects of buying prescription drugs from online pharmacies. The Walters Law Group specialises in Internet advertising law and has experience in cases involving online pharmaceutical retailers.
#015: Dr. Terry Wahls Discusses Cognitive Rehabilitation from Neurological Disease

50:06 | May 21st, 2013

Dr. Terry Wahls has managed to significantly reduce Multiple Sclerosis' impact on her life by self-experimentation, after a deep study of basic science research and animal-model neurological studies in mammals like mice.