36:44 | Jun 29th, 2018
Some aspects of our internal mental life seem to defy measurement. "Intuition" seems like a prime example of something impossible to quantify... But what if it's not? Dr. Joel Pearson tells us about his ingenious studies putting a value on human in...Show More
44:34 | May 29th, 2018
Our senses provide us with a best-guess interpretation of reality -- but it's only a guess. Dr. Anil Seth explains how perception and consciousness interact, and how we can intentionally shift our "reality filter" with methods like induced synesthes...Show More
50:01 | May 5th, 2018
You don't think much about your electricity until the power goes out. And human metabolism is kind of the same way. Dr. Navdeep Chandel explains why metabolism is worth paying attention to -- for lifespan, healthspan, and for dodging disease.
52:38 | Apr 21st, 2018
"Schizophrenia" is a word that strikes fear in the hearts (and minds) of those who have seen its effects. It's often misunderstood -- but one aspect that's universally recognized is that it's a *big deal.* And it affects nearly 1% of the adult popul...Show More
56:46 | Mar 30th, 2018
Ketogenic Diets, Ketone Salts, Ketone Esters... What does all this mean -- and which ones will help turn your brain into a well-lubricated fat-burning engine most easily? Dr. Brianna Stubbs -- who is a biohacker and world-class athlete as well as a ...Show More
1:04:06 | Mar 9th, 2018
It's easier to smoke marijuana legally these days than it is to study it. Strange, but true. But with tens of millions of Americans using recreational marijuana regularly...isn't it time we learned what it's doing to our brains?
48:40 | Mar 3rd, 2018
Social scientists have built up a wealth of knowledge about the ways the human brain reliably gets things wrong. Luckily for us - if we stay conscientious, we can work around our built-in bugs.
39:25 | Jan 27th, 2018
Music, maybe second only to language, seems to be one of the defining characteristics of the human brain -- and an abiding interest for all known human cultures. And it turns out to be both a read/write interface.
44:05 | Jan 12th, 2018
Ibogaine could be an effective therapy against addiction -- or it could be (literally) the cure that kills the patient. Hear about the many facets of this plant-derived substance from Dr. Emeline Maillet.
36:11 | Dec 30th, 2017
Conventional wisdom holds that knowing more languages is "good for your brain." But what makes it so? And good in which ways? Dr. Ellen Bialystok is one of the world's foremost experts, and conducted many of the studies that has brought this "comm...Show More
38:47 | Dec 16th, 2017
Mind wandering is bad if you're operating a chain saw. But if you're stuck on a well-defined intellectual problem, it could be just the ticket. Christine Godwin explains the latest research in...um...what was I just talking about?
46:13 | Dec 2nd, 2017
If genes are the "Book of You," then epigenetics are the dog-eared pages marking the parts you're interested in right now. Dr. Daniel Stickler explains how to use this active overlay on genetic information to your advantage.
58:46 | Nov 11th, 2017
Ayahuasca may mark the first time that a nausea-inducing beverage has gotten...popular. But there may be valid medical reasons why "Mother" Ayahuasca -- a brew featuring strong psychedelic effects -- is becoming well known outside the Brazilian jung...Show More
30:52 | Nov 4th, 2017
Ambien is a well-known sleep aid, with over 40 million annual prescriptions in the US alone. It is not, however, a one-trick pony. Dr. Nick Bomalaski describes his review of numerous odd (and encouraging) examples of Ambien's effects on various neu...Show More
43:13 | Sep 15th, 2017
Teens take risks. But they're not "just plain stupid." And according to Dr. Dan Romer - facing off against conventional wisdom and neuroscientific consensus - the risks they take may be "the right risks" to prepare for adulthood.
43:55 | Sep 8th, 2017
Without the ability to think about thinking, how would you know if you're even thinking right? If the brain is the command center for the body, then metacognition is the control system for the command center.
47:17 | Sep 2nd, 2017
You wouldn't think to take LSD to fight atherosclerosis. But - strange though it may seem - psychedelic compounds may have still more hidden surprises: Powerful anti-inflammation properties that, in mice at least, show effects at psychologically inv...Show More
40:42 | Jul 1st, 2017
Steam, Water, Ice: The three classic phases of water are almost as familiar as water itself. So is it conceivable that the substance we know so well has secrets not only hiding in plain sight, but also hiding inside every cell in our body?
39:25 | Jun 24th, 2017
If scientific findings can't be replicated, what have we really found? That question is at the root of the "Replication Crisis" dividing the halls of science. Researcher and reform advocate Dr. Rolf Zwaan explains.
32:44 | Jun 15th, 2017
You'd think there's nothing to be said in defense of brain damage. You'd almost be right. But in a few rare cases, "Acquired Savant Syndrome" gives brain-injured people cognitive abilities they never had before.
40:51 | Apr 21st, 2017
It’s high time we covered acetylcholine — the most plentiful neurotransmitter in the body. And our Know Your Neurotransmitters series continues with the best guest possible to talk to us about acetylcholine.
33:25 | Mar 31st, 2017
Bad vision isn't all in the eye of the beholder: Sometimes it's in the brain. In this Overdose Edition, Helen Irlen describes the Meares-Irlen Syndrome, a neurological disorder she says makes visual processing unnecessarily difficult for millions of ...Show More
40:17 | Feb 4th, 2017
Omega-6 fatty acids are both essential and misunderstood -- occasionally even demonized as a too-prevalent part of the Standard American Diet. Dr. Chris Masterjohn explains the role they fill in the human diet, and against-the-grain advice on how to...Show More
57:08 | Dec 17th, 2016
Music is something beloved of people everywhere -- or at least, 98% of them (no joke - details within). Not surprisingly, music can provoke complex brain responses, both in terms of short term emotion and long-term learning and perceptual awareness....Show More
42:07 | Oct 29th, 2016
It's a two-for-one: Dr. Martin Monti and Dr. Kathleen Bell talk to us about the nature of traumatic brain injuries, when it’s a "no brainer" to go see a doctor, and how to create a brain resilient to injury.
56:00 | Jul 15th, 2016
Dr. Rick Strassman is something of a legend in the psychedelic research community. His studies in the early 1990s re-opened a door which had been securely bolted for almost three decades: a prohibition against testing psychedelics on human research ...Show More
17:24 | Jul 13th, 2016
Apologies for the ultra-brief post, but we wanted to get this Overdose Edition up quickly… The Flynn Effect is a strange-but-true revelation. Over the course of the 20th century — and apparently continuing still — “average” people in countries aroun...Show More
44:32 | Jun 24th, 2016
Rapamycin, derived from bacterium found on Easter Island, could help you live longer. Dr. Kaeberlein explains the science behind rapamycin, and how he's using it to help man's best friend live longer.
41:59 | May 13th, 2016
We’ve all heard of the 10,000 Hour Rule, but what about deliberate practice? Dr. Ericsson talks us through becoming an expert through deliberate practice, including visualization, finding a mentor, and more.
37:39 | May 6th, 2016
More intelligence is "lost" to inadequate fetal nutrition than to anything else, period. In this special Mother's Day episode, Jesse speaks with Dr. Kavitha Menon about the greatest dangers to the development of baby brains, in both the developing a...Show More
29:30 | Apr 29th, 2016
In episode 126, Professor Con Stough talks to Jesse about Bacopa, the oldest herbal medicine in the world. A powerful memory enhancer that promotes synaptogenesis, this is one herb you'll want to want to add to your medicine cabinet, regardless of y...Show More
48:58 | Apr 22nd, 2016
Brains and Brawn, long positioned as polar opposites, turn out to be anything but. In this episode, Jesse talks with fitness trainer Sal di Stefano -- also the co-host and resident science geek at the MindPump podcast -- about best practices to use ...Show More
42:27 | Apr 15th, 2016
Compounds in the hemp plant are so potent within the human body that an entire class of naturally-occurring molecules inside humans (the "endocannabinoids") are named after the plant -- not the other way around! In Episode 124, Jesse interviews ath...Show More
43:11 | Apr 8th, 2016
In his book "Consciousness and the Social Brain," Princeton neuroscientist Dr. Michael Graziano lays out his compelling Attention-Schema Theory. Has he solved the "Hard Problem" of Consciousness?
29:27 | Apr 1st, 2016
Dr. Andreet Mankala is the creator and leading advocate for one of the most cutting-edge medical procedures being performed today. At least, that's what her proponents say. Others are not so sure, pointing out that her experimental chakra transplanta...Show More
34:45 | Mar 25th, 2016
LabDoor's goal is full-spectrum testing of the majority of consumer supplements -- upwards of 10,000 different products. One piece of their innovative approach is to have users vote on what category of supplements gets added to their next battery of ...Show More
42:24 | Mar 18th, 2016
Dr. Mark Mattson, neurologist at Johns Hopkins University and the National Institute of Health (NIH), has decades of work in the fields of nutrition, brain health, and the complex interplay between diet, exercise, "feeding windows," and macronutrient...Show More
46:27 | Mar 12th, 2016
As the popularity of smart drugs and cognitive enhancement technologies becomes more widespread, questions of ethics and fairness rise to the surface. We remember that along with the scientific question of "can we" is the ethical sibling question "sh...Show More
45:40 | Mar 5th, 2016
The adaptogen plant turmeric has been a mainstay of Indian and Asian cooking for millenia. Its root is chock-full of bioactive curcuminoid compounds that have been shown to provide wide-ranging benefits from the reduction of oxidative stress to the ...Show More
18:16 | Feb 29th, 2016
"Textbooks are going to need to change." That was the general consensus around the 2015 discovery that previously unknown lymphatic vessels connect the brain directly to the immune system. Hear about the breakthrough discovery from co-discoverer Pro...Show More
50:27 | Feb 27th, 2016
"Grinders" take their stylistic queues from piercing shops, tattoo parlors and custom auto mechanics -- combining skills in electrical circuitry and biology to leap past "wearable" technology straight into integrated doodads like an LED compass that ...Show More
36:44 | Feb 19th, 2016
Dr. Frederick Barrett discusses recent and upcoming studies into psilocybin -- the psychoactive ingredient that puts the "magic" in magic mushrooms. This currently "Schedule 1" drug, in addition to reasonably reliably provoking mystical experiences ...Show More
39:19 | Feb 12th, 2016
There are times when social remembering can make our memories less accurate. However, by following the right strategies when remembering together -- creating a sort of "extended mind" -- we can improve our recall, particularly if those doing the rem...Show More
30:11 | Feb 6th, 2016
Is there a scalable way for people to benefit from others' experience without having to comb through Reddit threads and best-guess which writers' stories applied to them? Garrett Ruhland's search for a solution led to the formation of his company, ...Show More
50:31 | Jan 30th, 2016
The fallout from porn addiction goes beyond sexual dysfunction -- way beyond. The brain's dopamine system is the major motivational system for everything we do. Desensitizing it with surging arousal from porn can cause the brain to lower its overall...Show More
42:01 | Jan 23rd, 2016
Anthony Sims and Gary Demerjian are probably the two leading practicioners of the treatment of neurological conditions with mouth-worn orthodontic appliances -- based on soothing irritated nerves in the jaw to alleviate symptoms throughout the body.
47:30 | Jul 10th, 2015
Jesse is joined by cave-diver-cum-research-scientist Dr. Dawn Kernagis from IHMC (the Florida Institute for Human and Machine Cognition) for a chat about maintaining optimal cognition in extreme environments.
36:36 | Jun 19th, 2015
Ex-Navy SEAL Dr. Kirk Parsley joins Jesse this week for a candid discourse on sleep. From the pros and cons of biphasic sleep, to the importance of naps, to Doc Parsley’s personal experiences with sleep-deprived SEALs... This is an episode worth st...Show More
30:46 | Jun 11th, 2015
This first-ever Overdose Edition provides not only an interesting interview… We also get to ride side-saddle with professional researcher Drew Birnie, as he talks us through his research methodology, delving into the merits of the claims made about a...Show More
37:02 | May 29th, 2015
This week Jesse and Dr. Jeffry Strong wander into a forest of lesser known plant extracts, discussing Pycnogenol, a product derived from the bark of a unique species of pine trees. Its effects range from anti-oxidation and reduction of inflammation t...Show More
35:39 | May 15th, 2015
Jesse has a freewheeling discussion with John Danaher about "moral enhancement" technologies - old and new. They talk about emerging technologies, ethics and the notion that the mind extends much beyond our body and brain.
24:42 | Apr 4th, 2015
For the very first in our "Know Your Neurotransmitters" series, Jesse is joined by Dr. Matthew Broome to talk about the neurotransmitter GABA. Dr. Broome explains how GABA works, where it comes from, and how it affects our brains and bodies.
33:09 | Feb 26th, 2015
Dr. Longo shares with us his research on the beneficial effects of fasting on everything from our immune responses to our lifespans, and addresses some points of curiosity that arose over the course of our calorie-free week.
35:45 | Feb 19th, 2015
Professor Trevor Robbins, co-inventor of the Cambridge Neuropsychological Test Automated Battery (CANTAB) – a computer-based cognitive assessment system – explains its use for both neurodegenerative disease detection and cognitive enhancement efficac...Show More
38:09 | Feb 5th, 2015
IARPA's Dr. Adam Russell introduces us to the SHARP Program, which aims to uncover the most effective methods to optimize adaptive reasoning and problem-solving in high-performing adults working in cognitively-demanding environments.
29:30 | Jan 21st, 2015
We hear from Kyle Boyar, researcher at SC Laboratories, a quality assurance and safety testing facility for medical marijuana. Kyle takes us through some lesser-known facts about marijuana, its use as treatment for a variety of ailments, and its effe...Show More
31:26 | Jan 15th, 2015
Dr. Alexis Shields, naturopathic doctor and blood chemistry specialist, explains how blood chemistry analysis can be used to monitor and improve overall health, and how the insights we gain can help us maintain optimal neurotransmitter levels and boo...Show More
41:48 | Dec 14th, 2014
In Episode #56, Dr. Thomas N. Seyfried of Boston College stops by to introduce us to his research on cancer as a metabolic disease – not a genetic one. He explains how regular therapeutic fasting can increase mitochondrial respiration, and how calori...Show More
38:20 | Nov 17th, 2014
Alan Cash, physicist and entrepeneur behind benaGene Advanced Anti-Aging supplement introduces us to oxaloacetate and talks us through its positive CRON (Calorie Restriction with Optimal Nutrition)-mimicking effects.
51:27 | Nov 9th, 2014
In Episode #51, Jesse speaks with Dr. Michael A. Crawford of Imperial College London about the role of seafood — and the essential fats they contain — in the evolution, development, and maintenance of our brains. Dr. Crawford shares with us a “coast...Show More
26:48 | Oct 23rd, 2014
Jesse speaks to Crash, owner of Float Lab Technologies, a sensory deprivation tank center in Venice Beach, California. Crash explains the ins and outs of the Float Lab experience, and what can happen to our minds when they're freed from all external ...Show More
28:40 | Oct 8th, 2014
In Episode #48, Jesse interviews Bill Harris, meditation guru, founder of The Centerpointe Research Institute, and creator of Holosync Audio Technology. Bill tells us how we can gain more self-awareness in order to exercise choice in our lives, and h...Show More
23:15 | Aug 12th, 2014
Jesse interviews Nathan Whitmore, creator of the open-source project "OpenBrainStim", an affordable alternative to commercial transcranial Direct Current Stimulation (tDCS) devices.
50:10 | Aug 3rd, 2014
We speak to Dr. Nicole A. Vincent and Dr. Emma A. Jane, co-authors of the article "Put Down the Smart Drugs," on the ethics of cognitive enhancement. Jesse weighs in with his own views on the speculative rights and wrongs of nootropics use.
33:08 | Jun 2nd, 2014
Dr. Urban brings to light facts about how some brain stimulants work (specifically Ritalin), how they were originally tested, and why imperfections in the testing methodologies could spell danger to mis-diagnosed or off-label users.
32:01 | Feb 9th, 2014
These findings will lead to the development of treatments for conditions associated with memory loss...and could have big implications for the next generation of smart drugs.
32:41 | Feb 1st, 2014
Dan Hurley's new book Smarter follows his personal investigation into brain-training and the growing number of means now available to people to literally improve their intelligence.
31:08 | Jan 24th, 2014
Mark is the author of several books: 8 Weeks to SEALFIT, Way of the SEAL, and Unbeatable Mind. SEALFIT – a personal-improvement regimen developed by Mark – is uniquely effective at developing elite level physical and mental fitness, helping trainees ...Show More
42:47 | Jan 17th, 2014
Dr. Wahls discusses her personal story of recovery from multiple sclerosis, her new book The Wahls Protocol, and the day-to-day choices that can extend your life, maximize your health and fend off the most common degenerative neurological diseases.
33:41 | Dec 27th, 2013
Dr. Dr. J. Lucas Koberda discusses the applications and benefits of LORETA Neurofeedback in brain disorders, sports and cognitive optimization.
35:59 | Dec 18th, 2013
Dr. Gomez-Pinilla's research is to investigate neuronal adaptation to environmental factors like diet -- and how this scales up to the whole-organism level.
38:02 | Dec 6th, 2013
Dr. Felipe Fregni, the director of the Laboratory of Neuromodulation and Center of Clinical Research Training, talks about his research into the use and benefits of Transcranial Direct Current Stimulation (tDCS).
49:45 | Nov 6th, 2013
Dr. Neil Grunberg is one of the leading minds in the study of nicotine. He's spent almost thirty years studying the effects of nicotine on the body and brain. In this episode, he shares his wealth of knowledge regarding nicotine, and why he considers...Show More
42:10 | Oct 3rd, 2013
This combination of ingredients, says Abelard, provided him with an immediate boost in desire-to-learn, as well as what felt like an ability to learn... And for the past two-plus years, he has been testing and refining what he came to call the "CILTE...Show More
34:19 | Sep 22nd, 2013
As the Placebo Effect relates to nootropics, it's important to recognize that the brain learns the resulting "feel" of nootropics, just like any other drug. You are almost certainly experiencing placebo effects bolstering even your most effective no...Show More
27:48 | Jul 20th, 2013
Aniracetam has been reported to yield significant increases in cognitive functioning and abilities. This is further enhanced by its effects on memory recall and, probably more importantly, its high-level effects on learning. To add to that, the drug ...Show More
20:53 | Jun 26th, 2013
"We are on the cutting edge here at Smart Drug Smarts, but I don't think the cutting edge is very sharp because I really don't feel much at all."
26:38 | Jun 12th, 2013
Dr. Naqvi advises his patients to get off of as many medications as possible, unless there is a proven upside – and especially if they are already on other medications with which their may be unknown interactions.
33:10 | May 29th, 2013
Lawrence G. Walters shares insights into the legal aspects of buying prescription drugs from online pharmacies. The Walters Law Group specialises in Internet advertising law and has experience in cases involving online pharmaceutical retailers.
50:06 | May 21st, 2013
Dr. Terry Wahls has managed to significantly reduce Multiple Sclerosis' impact on her life by self-experimentation, after a deep study of basic science research and animal-model neurological studies in mammals like mice.
32:25 | May 13th, 2013
Much of Judith Horstman's interest and writing concerns research and scientific advancements in protecting the brain against aging and repairing neurological wear-and-tear.
34:16 | May 2nd, 2013
Sebastian has methodically tested an impressive number of variables to determine their effects on his personal productivity and quality of life. From dairy products to smart drugs to the lighting in his sleep environment, he's tested (and continues ...Show More
34:00 | Apr 17th, 2013
Jesse gets into details on neurofeedback and attention disorders with cognitive scientist and UCLA Ph.D. Dr. Andrew Hill. They discuss using neurofeedback to improve mental performance, mindfulness and executive function as well as its implications ...Show More
34:36 | Apr 3rd, 2013
Dr. Barnard is a world-renowned nutrition expert and outspoken vegan, and the author of 15 books and host of three PBS television specials. He specializes in the effect people's diets have on their bodies and brains, and their propensity for Alzheim...Show More
34:29 | Mar 20th, 2013
Jesse interviews biochemist and pharmacist Phil Micans, advisor to both the London Anti-Aging Conference and British Longevity Society. With his Master's Degree in Biochemistry and as the editor-in-chief of Aging Matters Magazine, Mr. Micans is a hi...Show More
39:35 | Mar 11th, 2013
Philosopher David Pearce's ultimate goal is to recalibrate the Hedonic Treadmill of both humans and nonhumans so the average level of enjoyment is much higher in the future than in today's world.
34:57 | Feb 17th, 2013
Marketed as "Virtuous Nutrients for Your Vices," these nutritional supplements were designed to re-balance the brain's neurochemistry following drinking or recreational drug use.
37:48 | Jan 19th, 2013
"You don't have to read brain science or learn calculus to get smarter... You can move away from rote thinking and engage your frontal lobes...by transform[ing] information in ways that are meaningful."
22:46 | Jan 3rd, 2013
Lee describes his Adderall experiences and why - despite its short-term upsides - he felt the need to combat ADD in a way that avoided Adderall's side effects... Eventually leading to the creation of his own self-designed nootropics "stack."
26:44 | Dec 25th, 2012
NeurOptimal is a non-invasive, non-drug-based brain optimization system which allows a subject to hear an audio representation of his or her brain's electrical output in real time.
32:27 | Nov 29th, 2012
Dr. Dean explains how his groundbreaking book evolved from a technical manual for his patients into a widely-known book to improve brain activity through smart drugs. “We were really focusing more on improving cognitive abilities of normal people wh...Show More