Trainee Pearls Podcast
1) #18 Jurjen Versluis: Transplant for high-risk MDS
Allogeneic hematopoietic cell transplantation (HCT) in patients with myelodysplastic syndrome (MDS) improves overall survival. The authors evaluated the impact of MDS genetics on the benefit of HCT in...Show More
2) #17 Nathanial Anderson: Signatures and persistence of CAR-T cells
In this study, Nathanial and colleagues systematically analyzed CD19 CAR-T cells of 10 children with R/R B-ALL enrolled in the CARPALL trial via high-throughput single-cell gene expression and T cel...Show More
3) #16 Aina Oliver-Caldés: Academic CAR-T cells for myeloma
Chimeric antigen receptor (CAR) T-cell therapy is a promising option for patients with heavily treated multiple myeloma. Point-of-care manufacturing can increase the availability of these treatments ...Show More
4) #15 Francesca del Bufalo: CAR-T cells for neuroblastoma
Immunotherapy with chimeric antigen receptor (CAR)–expressing T cells that target the disialoganglioside GD2 expressed on tumor cells may be a therapeutic option for patients with high-risk neurobla...Show More
5) #12 Justin Loke: Cytogenetics and TP53 in BMT for AML
The presence of TP53 mutations is associated with an unfavorable outcome in patients allografted for acute myeloid leukemia (AML), leading some to question the benefit of an allogeneic ste...Show More
6) #11 Ferran Nadeu: Early seeding of Richter transformation
Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms dri...Show More
7) #10 Elsa Bernard: IPSS-M in MDS
Risk stratification and therapeutic decision-making for myelodysplastic syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS-R), which considers hematologic parameter...Show More
8) #9 Alice Bertaina: Stem cell-kidney transplant for SIOD
Schimke immuno-osseous dysplasia (SIOD) is a multisystem disorder that is inherited in an autosomal recessive pattern. It usually manifests first with growth failure. Other features of the...Show More
9) #8 Marie Passet: Novel high-risk B-cell ALL
Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults remain incompletely elucidated. To uncover novel oncogenic drivers, Marie and her team performed RNA-...Show More
10) #7 Rafal Machowicz: Transplant for HLH
Hemophagocytic lymphohistiocytosis (HLH; hemophagocytic syndrome) is a rare syndrome of potentially fatal, uncontrolled hyperinflammation. Allogeneic hematopoietic stem cell transplantatio...Show More