Sapio with Buck Joffrey Podcast
1) 169: Protein Folding Errors Contribute to Aging and Disease
In this episode, we are joined by Dr. Judith Frydman to explore proteostasis: the tightly regulated systems that ensure proteins are correctly folded, maintained, and cleared before they become toxic....Show More
2) 168: Best of 2025
Over the past year, we covered a wide range of ground—from clinicians working directly with patients to top scientists studying the underlying biology of aging. This episode is a chance to look back a...Show More
3) 167: Why Bats Don't Age and Why You Should Care
Aging is usually linked to size, metabolism, and inevitable decline—but bats defy all three. In this episode, Dr. Buck Joffrey speaks with Dr. Emma Teeling about why bats are rewriting the rules of lo...Show More
4) 167: BioXcellerator - The Cutting Edge of Stem Cell Therapy
Longevity medicine is moving beyond symptom management—and regenerative therapies are forcing a deeper look at how healing actually works. In this episode, Dr. Buck Joffrey speaks with the team at Bio...Show More
5) 165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo
Aging begins when cellular quality-control systems lose their precision. In this episode, Professor Ana Maria Cuervo outlines how chaperone-mediated autophagy (CMA)—a selective lysosomal degradation p...Show More
165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo
35:14 | Dec 8th, 2025
6) 164: Young Blood Can Rejuvenate Old Brains with Dr. Tony Wyss-Coray
In this episode, we are joined by Dr. Tony Wyss-Coray to discuss his groundbreaking research on brain resilience and aging. He explains how systemic factors, particularly proteins in the blood, influe...Show More
7) 163: How Mitochondrial Decline Drives Brain Aging with Dr. Francisco Gonzalez-Lima
In this episode, we are joined by Dr. Francisco González-Lima to delve into the metabolic mechanisms that drive brain aging and cognitive decline. He begins by outlining how reductions in cytochrome o...Show More
163: How Mitochondrial Decline Drives Brain Aging with Dr. Francisco Gonzalez-Lima
59:18 | Nov 24th, 2025
8) 162: The Habits of Healthy Aging with Dr. Kate Wolin
We are joined by behavioral epidemiologist Dr. Kate Wolin to unpack why so many health interventions collapse outside the lab—and what actually drives lasting change in the real world. From frictionle...Show More
9) 161: Dr. Jennifer Elisseeff - The Future of Tissue Regeneration
In this episode, we have Dr. Jennifer Elisseeff joining us to discuss the evolving field of tissue engineering and its applications in regenerative medicine. She explains the shift from using stem cel...Show More
10) 160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum
Dr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging. She explains how these simple o...Show More
160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum
32:49 | Nov 3rd, 2025