This Week in Microbiology

Vincent Racaniello

This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produ...Show More
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197: Intercellular microbial trade

1:10:25 | Apr 26th

The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components.
196: I hear you

1:03:38 | Mar 29th

The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function.
195: Gingipain in the Alzheimer brain

1:14:32 | Mar 4th

Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer’s disease.
194: Standard imperial procedure

1:05:27 | Feb 14th

How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli.
193: Persisters

1:00:45 | Jan 31st

The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment.
192: A Qtip for phages

1:06:22 | Jan 18th

The TWiM team reveals an extremely low rate of mutation in a 2500 year old, 185 acre fungus in Michigan, and how a host-produced quorum sensing autoinducer controls the phage switch between lysis and lysogeny.
191: By the pulp of their teeth

1:01:36 | Dec 21st, 2018

The TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria.
190: Exosomes in your nose and in your gut

1:18:51 | Dec 7th, 2018

The TWiM-opods consider two stories about exosomes, vesicles that are shed from cells: those that eliminate airway pathogens, and those from the plants we eat that shape our gut microbiome. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele Swa...Show More
189: Salmonella BonJovi

1:11:05 | Nov 16th, 2018

The TWiM team considers the state of the world’s fungi as revealed by a report from the Kew Royal Botanical Gardens, and how Salmonella loses motility to evade host defenses.
188: Turducken antibiotics

1:20:45 | Oct 31st, 2018

The TWiM rock stars show how to modify gram-positive antibiotics so they can kill gram-negative cells, and bacteria that have both DNA and RNA in their genome.
187: Rounding up the bees

1:06:29 | Oct 19th, 2018

The TWiM people reveal that phages must cooperate to overcome CRISPR-Cas defenses, and the effect of the herbicide glyphosate on the gut microbiome of honey bees.
186: Crypto-metamorphosis

1:13:24 | Oct 5th, 2018

The TWiM team describe the involvement of a microbiome in snail metamorphosis, and using Listeria to kill tumors.
185: There’s no moa Moa

1:08:22 | Sep 21st, 2018

The TWiM team considers the increasing tolerance of Enterococcus to handwash alcohols, and how the study of DNA in ancient dung reveals the diet and parasite burden of extinct New Zealand birds.
184: CRISPR-Cas immune systems

1:26:09 | Sep 7th, 2018

Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University.
183: Two symbioses

57:04 | Aug 23rd, 2018

The TWiMpeeps discuss two symbioses: a parasitoid bacterium of a heterotrophic protist, and fungal parasites in cicadas.
182: A micro story with macro implications

1:05:47 | Aug 9th, 2018

The TWiM hosts reveal how to test antimicrobial susceptibility in less than 30 minutes, and a carbonate-sensitive phytotransferrin in diatoms that controls iron uptake.
181: Dr. Warhol’s Periodic Table of Microbes

58:01 | Jul 26th, 2018

Vincent speaks with John Warhol about state microbes, the Periodic Table of the Microbes, and why microbiology is cooler than astrophysics, but they have better TV shows. Host: Vincent Racaniello Guest: John Warhol Subscribe to TWiM (free) on Apple P...Show More
180: Microbecentricity with Mark O. Martin

1:04:24 | Jul 13th, 2018

Vincent speaks with Mark O. Martin about microbial centricity, teaching undergraduates microbiology, lux art, painting with glowing bacteria, tardigrades and much more at ASM Microbe 2018. Host: Vincent Racaniello Guest: Mark O. Martin Subscribe to T...Show More
179: Viable but not culturable

1:16:05 | Jun 29th, 2018

The TwiModulators discuss aerosolization of bacteria and viruses in an ocean-atmosphere mesocosm, and how the common practice of decontaminating produce with chlorine produces viable but non-culturable pathogens. Become a patron of TWiM. Links for th...Show More
178: Corals are sexy with Christina Kellogg

1:04:48 | Jun 15th, 2018

The TWiM team travels to ASM Microbe 2018 in Atlanta, Georgia to speak with Christina Kellogg about her career and her research on coral microbial ecology.
177: Microbial sibling conflict

54:38 | Jun 1st, 2018

The TWiM team discuss bacteriophage evolution in a dairy plant, and killing of less fit cells among social microbes.
176: Elio has lots of colanic acid

59:48 | May 17th, 2018

Vincent, Michael and Elio note the passing of Stanley Falkow, give E. coli an archaeal membrane, and show how the microbiome can make worms live longer.
175: Neomycin is antiviral

1:03:06 | May 2nd, 2018

The TWiM team notes the passing of Allan Campbell, and explains how aminoglycoside antibiotics like neomycin enhance host resistance to viral infection.
174: A Gathering Typhoid Storm

1:02:25 | Apr 19th, 2018

The TWiMsters explain why untreatable typhoid fever might be on the way, and the evolution of fungal virulence in tropical frogs.
173: Gee whiz in style

58:34 | Mar 30th, 2018

The Masters of the Microbiological Universe discuss the humongouest fungus, and a commensal bacterium that protects against skin neoplasia.
172: Unfolding relaxases and soil malacidins

1:13:32 | Mar 15th, 2018

The TWiMmers discuss culture-independent discovery of malacidin antibiotics, and unfolding of relaxase during bacterial conjugation.
171: If you give a bee a fungus

1:00:33 | Feb 22nd, 2018

The TWiM team explores a stingless bee that requires a fungal steroid to pupate, and colonic biofilms containing tumorigenic bacteria in patients with colorectal polyps. Hosts:  Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Subscribe to T...Show More
170: Rats, lice, and nanoparticles

55:54 | Feb 8th, 2018

The TWiM team reveals that spread of plague was likely by human ectoparasites, not rats, and deconstruct a durable, broadly protective protein nanoparticle influenza virus vaccine. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio...Show More
169: Breatharian Bacteria

1:02:28 | Jan 23rd, 2018

The cast of TWiM reveals how uropathogenic E. coli use a copper-binding protein to treat copper as a nutrient or a toxin, and Antarctic soil bacteria that survive on trace atmospheric gases. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanso...Show More
TWiM #168: The lesser of two weevils

1:16:35 | Jan 5th, 2018

Dickson joins the TWiM team to discuss the nasal microbiota of dairy farmers, and attenuation of bacterial virulence by quorum sensing in the maize weevil. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele Swanson. Guest: Dickson Despommier Su...Show More
TWiM #167: I have one word for you: Flink

52:40 | Dec 22nd, 2017

How pandemic influenza viruses suppress immunogenic cell death, and 3D printing of bacteria into functional materials.
TWiM #166: Dark fermentation

51:13 | Dec 7th, 2017

Vincent and Elio discuss the reason for poor efficacy of one of the influenza virus vaccines, and using a hyperthermophilic anaerobe to produce hydrogen from fruit and vegetable wastes in seawater. Hosts:  Vincent Racaniello and Elio Schaechter. Sub...Show More
TWiM #165: Pumping Copper

1:03:19 | Nov 30th, 2017

The TWiM team discusses the use of copper on exercise weights to reduce bacterial burden, and the mechanism of antigenic variation by which a fungus that causes severe pneumonia escapes the immune system. Hosts: Vincent Racaniello, Elio Schaechter, ...Show More
TWiM #164: Indiana Quorum

59:10 | Nov 16th, 2017

From Indiana University, Vincent speaks with Ankur, Julia, and Xindan about their careers and their work on horizontal gene transfer, quorum sensing, and chromosome organization in bacteria. Guests: Ankur Dalia, Julia Van Kessel, and Xindan Wang Watc...Show More
TWiM #163: Saliva and sptR/S

1:06:17 | Nov 2nd, 2017

This episode is all about saliva: how certain bacteria survive in it, and how swallowing saliva might cause intestinal inflammation. Links for this episode: Genes for the Streptococcus pyogenes fitness in human saliva (mSphere) Swallowed bacteria dr...Show More
TWiM #162: Intracellular bacteria with flagella

52:42 | Oct 13th, 2017

The TWiM hosts and associated microbiomes review a fungus destroying salamanders in Europe, and genes for flagella in intracellular bacteria. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) ...Show More
TWiM #161: Eros, a bacterial aphrodisiac

55:56 | Sep 21st, 2017

From the TWiM team, a discussion of Hurricane Harvey microbiology, and a bacterial enzyme that induces eukaryotic mating. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free) on iPhone, Android, ...Show More
TWiM #160: On the road to virus

1:07:04 | Sep 8th, 2017

The TWiM team provides an update on Zika virus, and reveals a plasmid on the road to becoming a virus.
TWiM #159: Immunophage synergy

1:00:36 | Aug 31st, 2017

The TWiM team pays a tribute to Chris Condayan, and investigates the synergy between virus and the innate immune system for clearing bacterial pneumonia by phage therapy.
TWiM #158: The bottom line

1:05:01 | Aug 10th, 2017

prokaryotic viral DNA in mammalian brain, and how diarrhea is beneficial, by clearing enteric pathogens.
TWiM #157: Back to the ancestor

56:43 | Jul 27th, 2017

The TWiMbionts explore the role of bacteria in the genesis of moonmilk, and how ancient host proteins can be used to engineer resistance to virus infection.
TWiM #156: Gifted microbes and defensive symbiosis

57:56 | Jul 13th, 2017

The TWiM team explains the use of microbial genome mining to identify new drugs, and how a bacterial symbiont protects flies against parasitoid wasps. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter. Subscribe to TWi...Show More
TWiM #155: Living in the stomach of a cell

57:28 | Jun 29th, 2017

Michele updates the TWiMers on Legionella in the Flint water supply, and Elio informs us about how horizontally acquired biosynthesis genes boost the physiology of Coxiella burnetii. Hosts:  Vincent Racaniello, Michael Schmidt, Michele Swanson and El...Show More
TWiM #154: Rigor, lotteries, and moonshots

1:14:22 | Jun 14th, 2017

At Microbe 2017 in New Orleans, the TWiM team speaks with Arturo Casadevall about his thoughts on the pathogenic potential of a microbe, rigorous science, funding by lottery, and moonshot science. Hosts:  Vincent Racaniello, Michael Schmidt, Michele ...Show More
TWiM #153: Covert pathogenesis

57:35 | May 30th, 2017

The TWiM team ventures into preprint space with an analysis of type VI secretion across human gut microbiomes, and provide insight into urinary tract infection: how bladder exposure to a member of the vaginal microbiota triggers E. coli egress from l...Show More
TWiM #152: Wooden steps

51:09 | May 19th, 2017

The TWiMmers get cozy with symbionts: the bacteria that allow a giant shipworm to oxidize sulfur, and algae that live within salamander cells. Hosts:  Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Subscribe to TWiM (free) on iPhone, Andro...Show More
TWiM #151: Bat and moth antimicrobials

59:49 | May 4th, 2017

The TWiMsters discuss potential new sources of antimicrobial compounds from unusual places: the skin of bats and the intestines of moths. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Subscribe to TWiM (free) on i...Show More
TWiM #150: Microbiology is where it’s at

1:01:21 | Apr 20th, 2017

In recognition of National Medical Laboratory Professionals Week, Robin Patel speaks with the TWiM team about directing a clinical bacteriology laboratory, and how an observation made by a laboratory technologist lead to the finding that Ureaplasma s...Show More
TWiM #149: You’re going to learn R

1:02:54 | Apr 6th, 2017

The TWiM team speaks with Pat Schloss about assigning sequence data to operational taxonomic units, and his experience with mSphere Direct, a new way of submitting papers for publication. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, ...Show More
TWiM #148: Neanderthal Dentistry

55:28 | Mar 23rd, 2017

Vincent, Elio, and Michael reveal what Neanderthals ate from analysis of DNA in their teeth, and new CRISPR-Cas systems found in the genomes of uncultured microbes. Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt. Subscribe to TWiM (f...Show More
TWiM #147: The Public Goods Dilemma

1:06:38 | Mar 10th, 2017

The TWiM hosts reveal why phosphorus is essential for fungal brain disease, and how bacteria kill local competitors to favor the evolution of public goods cooperation. Hosts:  Vincent Racaniello, Michele Swanson, Michael Schmidt, and Elio Schaechter....Show More
TWiM #146: Viral arbitrium

53:57 | Feb 23rd, 2017

Vincent, Elio and Michael discuss the finding of a prion in bacteria, and how communication between bacteria guides the decision between lysis and lysogeny. Hosts:  Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Subscribe to TWiM (free) on...Show More
TWiM Special: Q fever with Robert Heinzen

1:04:51 | Feb 16th, 2017

Host: Vincent Racaniello Guest: Robert Heinzen At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Robert Heinzen about the work of his laboratory on Q fever and its causative microbe, Coxiella burneti.   Become a Patron of TWi...Show More
TWiM #145: Anything but academic

1:02:44 | Feb 9th, 2017

Vincent meets up with Catharine Bosio, Michael Merchlinsky, and Shilpa Gadwal at the ASM Biothreats meeting to talk about careers for scientists outside of the ivory tower. Become a patron of TWiM. Links for this episode: ASM Biothreats 2017 Rocky ...Show More
TWiM #144: Did eukaryotes invent anything?

1:06:04 | Jan 26th, 2017

The TWiMers discuss how changes in domestic laundering affect the removal of microorganisms, and assembly of a nucleus-like structure during viral replication in bacteria. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swan...Show More
TWiM #143: E-scaffolds and receptor transfer

1:05:42 | Jan 12th, 2017

Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins. Hosts:  Vincent Racaniello, Michael Schmidt, and Michele S...Show More
TWiM #142: A membrane-thickness caliper

58:37 | Dec 29th, 2016

Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness. Hosts:  Vincent Racaniello, Elio Schae...Show More
TWiM #141: Nutritional immunity and polymicrobial infections

1:05:54 | Dec 15th, 2016

Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity. Hosts:  Vincent Racaniello, Elio Schaechter, and Michael Schmidt. Guest: Je...Show More
TWiM 140: Small town, big science

1:20:13 | Dec 1st, 2016

Host: Vincent Racaniello Guests: Marie Antonioli, Bryan Hansen, Forrest Jessop, Kyle Shifflet and Jim Striebel At the Hamilton, Montana Performing Arts Center, Vincent speaks with three local high school graduates and two high school teachers about h...Show More
TWiM #139: Frackibacter and sticky fingers

1:11:27 | Nov 18th, 2016

The TWiM team discusses microbial DNA found on ATM machines in New York City, and how hydraulic fracturing, or fracking, alters microbial ecosystems deep in the Earth. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson....Show More
TWiM #138: Learning to love uranium and the A-baum

1:02:09 | Nov 3rd, 2016

The TWiM team brings you a bacterium from a Colorado field site that grows on uranium, and copper resistance in the emerging pathogen Acinetobacter baumannii. Hosts:  Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson. Subscrib...Show More
TWiM #137: The battle for oxygen

1:08:54 | Oct 20th, 2016

Highlights of the Recent Advances in Microbial Control meeting in San Diego, and expansion of a gut pathogen by virulence factors that stimulate aerobic respiration. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson. Su...Show More
TWiM #136: Diderms and then monoderms

48:43 | Oct 7th, 2016

Them TWiM team discusses the importance of neutrophils in microbial infections, and evidence that ancient bacteria had two cell walls. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on iTune...Show More
TWiM #135: Unruly individuals and their unruly friends

1:06:41 | Sep 23rd, 2016

Links for this episode Dysbiosis of microbiome in critical illness (mSphere) Consequences of sewage spill into aquatic environment (App Env Mic) EPA recreational water guidelines (pdf) VRE following sewage spill (Outbreak Radio) FAQ: Human microbiom...Show More
TWiM #134: Lipids that live forever

1:04:23 | Sep 8th, 2016

Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Miche...Show More
TWiM #133: Right under our noses

1:01:03 | Aug 20th, 2016

Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM. Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt. Subscri...Show More
TWiM #132: Bacteria learn long division

57:25 | Aug 5th, 2016

Vincent, Elio, and Michele present cell division by longitudinal scission in an insect symbiont, and thermally activated charge transport in microbial nanowires. Hosts: Vincent Racaniello, Michele Swanson and Elio Schaechter. Subscribe to TWiM (free)...Show More
TWiM 131: Mice behaving badly

1:22:09 | Jul 20th, 2016

Hosts: Vincent Racaniello and Michael Schmidt Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring ...Show More
TWiM #130: Interkingdom interactions at ASM Microbe

1:17:28 | Jun 23rd, 2016

Filmed live in Boston, MA at Microbe 2016, David S. Schneider and Vanessa Sperandio talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help...Show More
TWiM #129: Dried and wrinkled, smooth and mucoid

1:10:40 | Jun 7th, 2016

The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele. Im...Show More
TWiM #128: A moonlighting phage protein

1:17:35 | May 21st, 2016

A eukaryote without a mitochondrion, and using a phage enzyme to eliminate intracellular bacteria are two topics discussed by the TWiMers on this episode. Image (right): An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one o...Show More
TWiM #127: Subway Snowblowers and Men in Black

54:27 | May 5th, 2016

The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease. Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Vis...Show More
TWiM #126: I’m not scared of zebrafish and mice and bears (oh my!)

1:07:00 | Apr 22nd, 2016

The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele. Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. Subscribe to...Show More
TWiM #125: A minimal cell operating system

57:50 | Apr 7th, 2016

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. A deep sequencing study of commercially available probiotics, and design and synthesis of a minimal bacterial genome are the topics tackled by Vincent, Michael, and Michele on this epi...Show More
TWiM #124: Fungal pirates

1:03:15 | Mar 24th, 2016

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt. Vincent, Michael, and Michele reveal how a fungal protease blunts the innate immune response and promotes pathogenicity. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email...Show More
TWiM #123: A microbial MAGE

1:15:28 | Mar 9th, 2016

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter. Guest: Harris Wang Harris joins Vincent, Elio, and Michael to describe multiplex automated genome engineering, a method for targeting many modifications in a population of bacterial c...Show More
TWiM #122: Mayonii, microRNAs and the microbiome

1:03:33 | Feb 25th, 2016

Vincent, Michele, and Michael reveal the discovery of a new species of the spirochaete that causes Lyme disease, and fecal microRNAs that shape the gut microbiome. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen o...Show More
TWiM #121: A plague of pathogens

57:52 | Feb 11th, 2016

Host: Vincent Racaniello Special guests: Rebekah Kading and Wyndham Lathem From the ASM Biodefense and Emerging Diseases Research meeting, Vincent speaks with Rebekah and Wyndham about their work on Rift Valley Fever virus and other vector-borne pa...Show More
TWiM #120: Snakes in trouble

49:02 | Feb 2nd, 2016

Hosts: Vincent Racaniello and Elio Schaechter. Vincent and Elio marvel in the finding that a phage tail-like structure from a marine bacterium stimulates tubeworm metamorphosis, and reveal Ophidiomyces as a cause of snake fungal disease. Subscribe ...Show More
TWiM #119: Power of one

1:03:25 | Jan 16th, 2016

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter. The microbophiles investigate the ratio of bacterial to human cells in our bodies, and how placing solar panels on a bacterium enables it to carry out photosynthesis. Subscribe to TWi...Show More
TWiM #118: Spore-drops keep fallin’ on my head

1:05:35 | Jan 1st, 2016

Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson On the last episode for 2015, Vincent, Elio, and Michele discuss how soil amoeba hunt nematodes in packs, and the role of mushrooms as rainmakers. Subscribe to TWiM (free) on iTunes, St...Show More
TWiM #117: Finding the comammox

1:10:28 | Dec 17th, 2015

The TWiM team marvels over the finding of a completely nitrifying Nitrospira, and horizontal gene transfer from Wolbachia into an animal genome. Links for this episode: Complete nitrification by Nitrospira bacteria (Nature one, two) Enigmatic co...Show More
TWiM #116: Chewates and coconuts

1:00:58 | Dec 2nd, 2015

Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson The TWiMeriti reveal a Brazilian social bee that must cultivate a fungus to survive, and diet-mediated reduction in gut colonization by Candida albicans. Links for this episode  Bee ...Show More
TWiM #115: Profiling the Poglianos

56:23 | Nov 20th, 2015

Vincent visits the laboratories of Kit and Joseph Pogliano on the campus of the University of California, San Diego, where he learns about their work on the bacterial cytoskeleton, sporulation, and the effects of antibiotics on bacterial cells. Visi...Show More
TWiM #114: Milestones in Blue

1:11:00 | Nov 6th, 2015

Vincent, Elio, and Michele meet with Harry Mobley, Mary O’Riordan, and Vince Young at the University of Michigan, during the designation of the Department of Microbiology and Immunology as a Milestones in Microbiology site. They discuss how the labor...Show More
TWiM #113: Waves of Change

53:46 | Oct 22nd, 2015

Vincent meets up with Romney and Duncan at the 79th annual meeting of the Southern California branch of the American Society for Microbiology, where they talk about emerging technologies for antimicrobial susceptibility testing, and next generation s...Show More
TWiM #112: Mushroom pickers and mushroom kickers

1:00:42 | Sep 26th, 2015

The TWiM team wonders why definitions in biology often change, and discuss how the small molecule terrein is important for the growth of a soil fungus. Image: Lesion formation on banana surfaces infected with Aspergillus terreus. Source Links menti...Show More
TWiM #111: Ancientbiotics and modernbiotics

59:02 | Sep 10th, 2015

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter. The TWiMitos discuss the reconstruction of a 1,000-year-old antimicrobial remedy, and using gallium as an antimicrobial in the battle for iron. Subscribe to TWiM (free) on iTunes, Sti...Show More
TWiM #110: Exploring unseen life with unpronounceable words

1:11:45 | Aug 19th, 2015

The TWiM team focuses on the gut microbiome, from a single member, Akkermansia muciniphila, to the effect of antibiotics on its composition and colonization resistance against C. difficile. Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS,...Show More
TWiM #109: Precision killing

1:08:52 | Aug 6th, 2015

The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium Wolbachia selectively kills male hosts.   Links for this episode: Antimicrobial peptides to modulat...Show More
TWiM #108: Vaccine in the time of cholera

1:12:13 | Jul 23rd, 2015

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.   The professors of TWiM discuss a University of Wisconsin plan for rescuing biomedical research in the US, and results of a clinical trial in Bangladesh of an oral cho...Show More
TWiM #107: The battle in your bladder

1:31:06 | Jul 9th, 2015

Hosts: Vincent Racaniello and Michael Schmidt. Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the battle for iron. Subscribe to TWiM (free) on iTunes, via...Show More
TWiM #106: Lawn mower disease

1:16:32 | Jun 24th, 2015

Vincent and Michael speak with Katy Bosio about her research on pathogenesis, immunity, and vaccines against Franciscella tularensis, the causative agent of tularemia.
TWiM #105: Real bugs with legs

57:54 | Jun 5th, 2015

The TWiM team reviews the microbiological safety of herbs in the United Kingdom, and how a peptide from the milkweek bug binds the ribosome and inhibits bacterial protein synthesis.   Links for this episode:   Microbes in whole-leaf herbs (J ...Show More
TWiM #104: Feed me polyamines, biofilm

1:03:49 | May 21st, 2015

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.   The TWiM team discusses how measles vaccination protects against other infectious diseases, and links between bacterial biofilms and colon cancer. Subscribe to TWiM ...Show More
TWiM #103: The battle for iron

1:05:50 | May 8th, 2015

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.  The TWiM team is amazed by the ocelloid, and an evolutionary battle for iron between mammalian transferrin and bacterial transferrin-binding protein. Subscribe to TWi...Show More
TWiM #102: Happiness is the spore-formers in your gut

57:43 | Apr 24th, 2015

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.  The TWiM team discusses evidence that serotonin synthesis is regulated by spore-forming members of the gut microbiota. Subscribe to TWiM (free) on iTunes, via RSS fee...Show More
TWiM #101: The MRSA in your home

1:14:44 | Apr 1st, 2015

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.  The TWiMers discuss how aroma helps disperse yeast cells on insect vectors, and evidence that MRSA is transmitted within households. Subscribe to TWiM (free) on iTune...Show More
TWiM #100: Omnis cellula e cellula

50:38 | Mar 18th, 2015

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Jo Handelsman.   The TWiM team celebrates 100 episodes with a Talmudic question, and discussion of how a single mutation alters bacterial host tropism. Subscribe to TWiM (free) on iTun...Show More
TWiM #99: Careers in Biodefense

1:01:56 | Mar 4th, 2015

Hosts: Vincent Racaniello Guests: Maria Julia Marinissen, Edward H. You, and David R. Howell Vincent meets up with Maria, Edward, and David at the ASM Biodefense and Emerging Infections Research meeting to talk about alternative careers for scienti...Show More
TWiM #98: Bacteria and eukaryotes get horizontal

58:37 | Feb 19th, 2015

The TWiM crew ponders the question of how a bacterium finds its middle when dividing, then divulge the transfer of interbacterial antagonism genes to eukaryotes, where they may function in innate defense.   Links for this episode:   Size inde...Show More
TWiM #97: There’s gold in them hills

1:14:23 | Feb 4th, 2015

The TWiM team reveal how bacteria in a shipworm’s gills help digest wood in the gut, and an approach that identifies a new antibiotic from the soil.   Links for this episode:   Gill bacteria enable a novel digestive strategy (PNAS) Killi...Show More
TWiM #96: A lean, mean sequencing machine

54:39 | Jan 21st, 2015

Hosts: Vincent Racaniello. Special guest: Rob Knight Vincent meets up with Rob Knight to talk about the technology that has fueled his drive to sequence the Earth and its inhabitants. Check out the Microbeworld app. Links for this episode Micr...Show More
TWiM #95: A microbe lover in San Diego

1:06:22 | Jan 9th, 2015

Hosts: Vincent Racaniello. Special guest: Stanley Maloy Vincent meets up with Stan Maloy on the campus of San Diego State University to talk about his career in microbiology and his work as Dean of Science. Subscribe to TWiM (free) on iTunes, via ...Show More
TWiM #94: Nitrochondria

1:06:50 | Dec 25th, 2014

Vincent, Elio, and Michael discuss a symbiosis between a nitrogen-fixing cyanobacteria and a single-celled eukaryotic alga.   Links for this episode:   Unicellular cyanobacterium and alga symbiosis (Science) Diversity of nitrogen-fixing ...Show More
TWiM #93: Worming in on bacteria

56:30 | Dec 11th, 2014

Vincent, Elio, and Michael reveal that a soil-dwelling nematode can recognize and respond to a bacterial quorum sensing molecule through a sensory neuron.
TWiM #92: Flying biofilms

1:08:06 | Nov 27th, 2014

Vincent, Elio, Michael and Michele discuss the possible eradication of wild poliovirus type 3, and how microsporidian parasites prevent locust swarming behavior.
TWiM #91: Rats, viruses, and bacteria

58:32 | Nov 14th, 2014

Vincent, Elio, and Michele review a study of the viruses and bacteria in commensal rats in New York City. Visit for complete show notes. Thanks for listening!
TWiM #90: Think globally, act locally

1:02:15 | Oct 29th, 2014

Vincent meets up with Laurene and David at the Annual Meeting of the Southern California Branch of the American Society for Microbiology, where they discuss how the Los Angeles County Department of Health is preparing for an outbreak of Ebola virus i...Show More
TWiM #89: Microbial handoffs

1:13:14 | Oct 15th, 2014

Vincent, Michele, and Michael discuss how a gene from bacteria protects a tick from plant cyanide poisoning, and enhanced transmission of Streptococcus pneumoniae by influenza virus co-infection in mice.
TWiM #88: A century of excellence in microbiology

50:26 | Oct 1st, 2014

Michele speaks with members of the Department of Bacteriology at the University of Wisconsin - Madison, on the occasion of its designation as a Milestones in Microbiology site, where they discuss how the department has advanced the science and teachi...Show More
TWiM #87: Avogadro, archaeal fossils, and ICAAC

1:14:14 | Sep 17th, 2014

Vincent, Elio, and Michael explore the fossilization of archaeal lipids, and highlight the recent ICAAC in Washington, D.C.
TWiM #86: Blurring the line between organelle and endosymbiont

1:12:06 | Sep 3rd, 2014

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.  Vincent, Elio, Michael, and Michele consider whether our eating behavior is manipulated by gastrointestinal microbiota, and an aphid gene of bacterial origin whose gen...Show More
TWiM #85: Oscillation in the ocean and a Verona integron

1:17:48 | Aug 21st, 2014

Vincent, Elio, Michael, and Michele discuss the diel transcriptional rythmns of bacterioplankton communities in the ocean, and extensively drug resistant Pseudomonas in Ohio.
TWiM #84: Microbiology Down Under

1:08:43 | Aug 11th, 2014

In Melbourne, Australia Vincent speaks with David, Melanie, and Adam about their work on group A Streptococcus, Helicobacter pylori, and infections of Koalas with Chlamydia.
TWiM #83: Illuminating tuberculosis and cryptococcosis

1:19:09 | Jul 24th, 2014

Vincent, Michael, Elio and Michele review a new fluorogenic diagnostic test for tuberculosis bacteria, and the role of a metalloprotease in helping a fungus invade the central nervous system.
TWiM #82: Betrayal and compromise

1:11:48 | Jul 10th, 2014

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson. Vincent, Michael, Elio and Michele discuss how an endosymbiont betrays its aphid host to alert plant defenses, and a new immunosuppressive cell that allows infection of...Show More
TWiM #81: Cold iron is the master of them all

1:11:23 | Jun 28th, 2014

Vincent, Michael, and Michele discuss how iron might disperse bacterial biofilms in carotid arterial plaques, and controlling Salmonella by modulating host iron homeostasis.
TWiM #80: Hurling fleas and designer chromosomes

54:11 | Jun 11th, 2014

Hosts: Vincent Racaniello, Elio Schaechter, and Michele Swanson.  Vincent, Elio, and Michele discuss how to synthesize a designer yeast chromosome, and deciphering the genetic changes path that allowed Yersinia pestis to be transmitted by fleas. Li...Show More
TWiM #79: A community of microbiologists

1:11:32 | May 29th, 2014

Vincent, Michael, and Michele review highlights of the 2014 General Meeting of the American Society for Microbiology in Boston, MA.
TWiM #78: A bacterium grows in Brooklyn

1:03:57 | May 15th, 2014

Vincent, Elio, and Michael consider a fungal pathogen of insects that acquired a gene from its host that facilitates infection, and presence of gram-negative nosocomial pathogens on community surfaces near hospitals in Brooklyn.
TWiM #77: Zombie plants and no pain, no gain

1:08:21 | May 1st, 2014

Vincent, Elio, Michael, and Michelle review how a pathogen promotes plant attractiveness to insect vectors, and activation of sensory neurons that modulate pain and inflammation by bacterial infection.
TWiM #76: Genetic biopixels and a pathogenic sweet tooth

1:07:29 | Apr 11th, 2014

Vincent, Elio, Michael, and Michelle discuss the use of bacteria to build a genetic sensor for heavy metals, and how host sugars help enteric pathogens to expand after antibiotic treatment.
TWiM #75: Pellicles on pickle jars

1:21:51 | Mar 27th, 2014

Vincent, Elio, Michael, and Michelle discuss a symbiosis between a bacterium and fungus that increases the virulence of oral biofilms, and the assembly of amyloid fibers, which are needed for biofilm formation.
TWiM #74: It came from the Siberian permafrost

1:10:14 | Mar 12th, 2014

Vincent, Elio, and Michael discuss a huge 30,000 year old virus recovered from Siberia, and nested symbiosis facilitated by horizontal gene transfer from bacteria to insect.
TWiM #73: Eyeing root nodule development

1:19:38 | Feb 27th, 2014

Vincent, Michael, and Michele discuss how soil-dwelling bacteria induce the formation of root nodules on legumes via a protein called CYCLOPS.
TWiM #72: The benefits of virulence

1:14:10 | Feb 13th, 2014

Vincent, Elio, Michael, and Michele review how microbial virulence can be increased as a consequence of community surveillance and adaptation to macrophages.
TWiM #71: Colon cancer’s little shop of horrors

1:18:38 | Jan 22nd, 2014

Vincent, Michael, and Michele explain how the gut microbiome modulates colon tumorigenesis, and regulation of intestinal macrophage function by the microbial metabolite butyrate.
TWiM #70: A paroxysmal cough

1:13:12 | Dec 18th, 2013

Vincent, Elio, Michael, and Michele discuss evidence that the acellular pertussis vaccine fails to prevent infection and transmission in nonhuman primates, and the use of bacterial cytological profiling to identify pathways targeted by antibiotics.
TWiM #69: Bacterial DNA in the human genome

1:09:42 | Nov 27th, 2013

Vincent, Elio, Jo, and Michele review evidence for bacterial DNA integrated into the human genome, and control of the symbiont population in an insect midgut.
TWiM #68: The fungus among us

1:11:23 | Nov 14th, 2013

Vincent, Elio, Michael, and Michele discuss the amazingly high level of intergenera gene exchange among haloarchaea in an Antarctic lake, and the diversity of fungi on residential surfaces and the human forehead.
TWiM #67: Black mushrooms and RNA thermosensors

1:15:30 | Oct 30th, 2013

Vincent, Elio, and Michael discuss how temperature triggers Neisseria menigitidis immune evasion, and protection of mice from ionizing radiation by feeding them black mushrooms.
TWiM #66: The shape of a container

1:08:58 | Oct 17th, 2013

Vincent, Elio, Michael, and Michele discuss the curious outer membrane vesicles of Neisseria meningitides, and sources of Clostridium difficile infection revealed by genome sequencing.
TWiM #65: Leanness is transmissible

51:11 | Oct 3rd, 2013

Hosts: Vincent Racaniello and Michelle Swanson. Vincent and Michelle reveal how the human gut microbiota can modulate obesity in mice. Links for this episode:  Gut microbiota modulate metabolism (Science)  Fighting obesity with bacteria (Science) ...Show More
TWiM #64: URI and UTI at ICAAC in Denver

1:18:00 | Sep 18th, 2013

Vincent and Michael recorded this episode at the 53rd ICAAC in Denver, where they spoke with James Gern and James Johnson about rhinoviruses and extra-intestinal pathogenic E. coli.
TWiM #63: Superantigens, S. aureus, and the armpit microbiome

1:26:01 | Sep 4th, 2013

Vincent, Michael, and Michelle discuss how a Staphylococcus aureus superantigen is critical for pathogenesis in a rabbit model, and the relationship of body odor to the axilla microbiome.
TWiM #62: Breaking bad and protein chain mail

1:19:54 | Aug 21st, 2013

Vincent and Michael discuss how infection with influenza A virus disperses Streptococcus pneumoniae biofilms leading to disease, and an amazing protein chainmail in a viral capsid
TWiM #61: The irony of probiotics

59:38 | Aug 7th, 2013

Vincent, Elio, and Michele review how horizontal gene transfer from bacteria to an insect genome enables a tripartite nested mealybug symbiosis, and how probiotic bacteria work by competing for iron in the intestine.
TWiM #60: Microbial electrochemistry and diversity-generating retroelements

1:11:29 | Jul 24th, 2013

Vincent, Elio, and Michael discuss how an error-prone reverse transcriptase produces enormous diversity in a Legionella protein, and using microbes to convert waste into bioelectricity and chemicals.
TWiM #59: Are viruses part of our immune system?

1:24:55 | Jul 10th, 2013

Vincent and Michael discuss the finding that bacteriophage might be part of the mucosal antimicrobial defense system.
TWiM #58: The brain microbiome?

1:21:33 | Jun 20th, 2013

Vincent, Elio and Michael review how underground mycelial networks carry signals that warn neighboring plants of aphid attack, and the presence of bacteria in the human brain.
TWiM #57: Updating the human gut microbiome to degrade seaweed

58:34 | Jun 5th, 2013

Vincent, Elio and Michael discuss fungi that use pheromones to trap nematodes, and how genes obtained from marine bacteria help gut bacteria degrade algal carbohydrates.
TWiM #56: Live at ASM in Denver

1:42:04 | May 24th, 2013

Vincent, Elio and Michael recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Andrew, Ferric, Suzanne, and Michelle about their research on a phage s...Show More
TWiM #55: In the copper room

1:25:00 | Apr 24th, 2013

Vincent, Elio and Michael discuss the finding that copper surfaces reduce microbial burden and hospital-acquired infections in the intensive care unit.
TWiM #54: Dueling injectors and the microgenderome

1:12:36 | Apr 10th, 2013

Vincent, Elio, and Michael review how sex-dependent differences in the mouse microbiome regulate type I diabetes, and counterattack among bacteria.
TWiM #53: Live in Manchester

1:00:38 | Mar 29th, 2013

Vincent, Laura, David, Kalin and Paul get together at the Society for General Microbiology meeting in Manchester, England to talk about next-generation approaches to antimicrobial therapy.
TWiM #52: Clinical microbiology with Ellen Jo Baron

1:00:27 | Mar 11th, 2013

Vincent and Michael meet up with Ellen Jo Baron to talk about working in a clinical microbiology laboratory.
TWiM #51: Cave science with Hazel Barton

1:18:41 | Feb 27th, 2013

Vincent, Michael, and Elio meet up with Hazel Barton to talk about cave microbiology.
TWiM #50: These things aren’t even bacteria!

1:03:59 | Jan 30th, 2013

Vincent, Michael, and Stanley review the scientific career of Carl Woese.
TWiM #49: Grape-like Clusters

1:13:43 | Jan 16th, 2013

Vincent, Michael, and Elio discuss the HIV co-receptor CCR5 as a receptor for S. aureus leukotoxin ED, and the vineyard yeast microbiome.
TWiM #48: It’s all about direction

1:16:18 | Jan 3rd, 2013

Vincent, Michael, and Jo discuss how subtle gender bias of science faculty favors male students, and the relationship of invasive infection and antibody orientation at bacterial surfaces.
TWiM #47: Resistance on the surface

1:10:56 | Dec 19th, 2012

Horizontal transfer of antibiotic resistance genes on metal surfaces, and using bacteriophage to reverse antibiotic resistance.
TWiM #46: Spore!

1:09:33 | Dec 5th, 2012

Vincent, Michael, and Elio meet up with Jonathan Dworkin to discuss how bacteria form spores and how they return to vegetative growth.
TWiM #45: Secreted nucleic acids RIG a STING

1:11:53 | Nov 21st, 2012

Vincent, Michael, Elio review innate immune sensing of Listeria secreted bacterial nucleic acids, and how Wolbachia enhances egg production in Drosophila.
TWiM #44: Phage interruptus

1:06:08 | Oct 24th, 2012

Vincent, Michael, Elio discuss the role of prophage excision in exit of Listeria from the phagosome, and analysis of bacterial communities in saliva.
TWiM #43: Bacterial caveolae and zapping acne with phages

1:19:46 | Oct 10th, 2012

Vincent, Michael, Elio review formation of caveolae in a bacterium, and the limited genetic diversity and broad killing activity of P. acnes bacteriophages.
TWiM #42: Staphylococcus, a three-star pathogen

1:11:42 | Sep 26th, 2012

Vincent, Michael, Elio, and Joe review highlights of the 15th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI) in Lyon, France.
TWiM #41: ICAAC live in San Francisco

1:43:08 | Sep 13th, 2012

Vincent and Michael travel to San Francisco for the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), where they meet with Bill, John, and Victor to discuss tuberculosis, monitoring infectious disease outbreaks with onlin...Show More
TWiM #40: A mecca for microbiology

1:01:59 | Aug 29th, 2012

**MicrobeWorld app users, click the "e" symbol in the bottom right corner of this description to watch a bonus video version of this episode!** Vincent and Stanley meet with Waclaw Szybalski and John Kirby at Cold Spring Harbor Laboratory on the occ...Show More
TWiM #39: What Darwin never knew

1:15:30 | Aug 15th, 2012

Vincent, Michael, and Elio reviews chapters from Microbes and Evolution, a collection of short, personal essays by microbiologists.
TWiM #38: The sound of whooping cough

1:10:52 | Aug 2nd, 2012

Vincent, Jo, Michael, and Elio review an outbreak of pertussis in Washington, and how culturing can reveal rare members of the soil biosphere.
TWiM #37: Microbial Jekyll and Hyde

1:17:43 | Jul 18th, 2012

Vincent, Jo, Michael, and Elio discuss two examples of dynamic microbial symbioses that switch between mutualistic and pathogenic states.
TWiM #36: Domesticating a pathogen

1:20:24 | Jul 4th, 2012

Vincent, Michael, and Elio explore the origin of Mycoplasma pathogens of ruminants, and share their thoughts on the recent ASM General Meeting.
TWiM #35: Ohne hauch

1:09:58 | Jun 21st, 2012

Vincent, Michael, and Elio review necrotizing fasciitis, and a link between surface remodeling in gram-positive and gram-negative bacteria.
TWiM #34: Doing the DISCO with Emiliania

1:08:50 | Jun 4th, 2012

Hosts: Vincent Racaniello, Michael Schmidt, and Elio Schaechter Vincent, Michael, and Elio discuss changing populations of Emiliania huxleyi and their viruses in the North and Black Seas. Right click to download TWiM #34 (50 MB .mp3, 69 minutes). Lin...Show More
TWiM #33: Tuning the immune organ

1:08:26 | May 16th, 2012

Vincent, Michael, and Ivo review the requirement for segmented, filamentous bacteria for the induction of a specific type of helper T cell in the gut. Links for this episode: Induction of Th17 cells by segmented filamentous bacteria (Cell) Segment...Show More
TWiM #32: Not the shadow biosphere

1:06:55 | May 2nd, 2012

Rosie Redfield talks about her evidence that a bacterium cannot grow on arsenic instead of phosphorus.
TWiM 31: Screen door on a submarine

1:15:09 | Apr 18th, 2012

Hosts: Vincent Racaniello, Jo Handelsman, and Michael Schmidt Vincent, Jo, and Michael discuss an archetypal protein transport system in bacterial outer membranes, and evidence that gut microbial enterotypes might not fall into defined groups. Links ...Show More
TWiM #30: Unraveling melioidosis and insulin resistance

1:10:04 | Apr 4th, 2012

On episode #30 of the podcast, Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor.
TWiM #29: Death and an iron-loaded spike

1:02:48 | Mar 21st, 2012

On episode #29 of the podcast, Vincent and Stanley review how a phage pierces the cell membrane with an iron-loaded spike, and two programmed cell death systems in E. coli.
TWiM #28: Not unorganized bags of enzymes

1:17:13 | Mar 7th, 2012

Vincent, Michael, and Elio review how competition within a host drives virulence of Streptococcus pneumoniae, and the expanding universe of the bacterial cytoskeleton.
TWiM #27: An inflamed gut is good for Salmonella

1:14:31 | Feb 22nd, 2012

Vincent, Elio, and Michael review how inflammation allows Salmonella to compete with fermenting gut microbes, and a riboswitch in bacterial and Archeal species that is triggered by fluoride.
TWiM #26: Suum cuique

1:15:05 | Feb 8th, 2012

Vincent, Elio, and Michael discuss the finding of Sutterella species in the gut of autistic children, and methods for cultivating oral bacteria.
TWiM #25: Magnetotactic bacteria and totally drug resistant TB

1:16:55 | Jan 25th, 2012

On episode #25 of the podcast, Vincent, Elio, and Michael review bacteria that use the earth’s magnetic field for navigation, and identification of totally drug resistant Mycobacterium tuberculosis.
TWiM #24: This year in microbiology

1:19:23 | Jan 11th, 2012

Vincent, Michael, and Cliff review ten compelling microbiology stories from 2011.
TWiM #23: Fighting antibiotics with toxic gas and starvation

1:16:05 | Dec 28th, 2011

Vincent, Jo, Elio, and Michael explain how a swarming bacterium helps disperse a non-motile fungus, and bacterial antibiotic tolerance mediated by hydrogen sulfide and starvation responses.
TWiM #22: Microbiology 911

1:38:25 | Dec 14th, 2011

Vincent and Michael speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about microbial infections encountered in the emergency room.
TWiM #21: Symbiotic margheritas

1:08:29 | Nov 30th, 2011

Vincent and Elio discuss ancient symbiosis between Alphaproteobacteria and catenulid flatworms, and a toxin from Helicobacter pylori that engages the mitochondrial fission machinery to induce host cell death.
TWiM #20: Facebook for bacteria

1:07:51 | Nov 16th, 2011

On episode #20 of the podcast This Week in Microbiology, Vincent, Michael, and Elio follow up on the outbreaks of E. coli in Germany and cholera in Haiti, then discuss genes that confer self-identity to Proteus mirabilis.
TWiM #19: Your microbiome is what you eat

59:19 | Nov 2nd, 2011

Vincent, Michael, Elio, and Jo discuss the genome sequence of Y. pestis from victims of the Black Death, and the effect of diet on gut microbial enterotypes.
TWiM #18: Escherichia coli K-12, an emerging pathogen?

1:14:05 | Oct 19th, 2011

Vincent, Michael, Elio, and Stanley explain how to make the human intestinal commensal and benign laboratory bacterium Escherichia coli K-12 into an invasive organism, and the unearthing of century-old spores in New York City.
TWiM #17: Debugging endosymbiosis

1:10:31 | Oct 5th, 2011

Vincent, Michael, and Elio focus on endosymbiosis: the rapid spread of Ricekttsia in whitefiles, and a metabolic patchwork in nested symbionts of mealybugs.
TWiM #16: ICAAC Live

1:29:14 | Sep 22nd, 2011

On episode #16 of the podcast This Week in Microbiology, Vincent, Michael, Arturo, Stuart, and David converse about antimicrobial resistance and why most fungi do not cause disease at the 51st Interscience Conference on Antimicrobial Agents and Chemo...Show More
TWiM #15: Microbial long distance relationships

58:58 | Sep 7th, 2011

On episode #15 of the podcast This Week in Microbiology, Vincent, Michael and Jo review the number of species on Earth, evidence that the 2010 Haitian cholera outbreak originated in Nepal, and how gut microbiota influence the immune response to influ...Show More
TWiM #14: Vomocytosis and microbial transistors

1:07:48 | Aug 24th, 2011

On episode #14 of the podcast This Week in Microbiology, Stanley, Margaret, Michael and Elio review how the fungus Cryptococcus escapes from macrophages, and electrical conductivity in nanowires formed by the bacterium Geobacter.
TWiM #13: Probiotics and inflammasomes: Telling good bacteria from the bad

57:44 | Aug 10th, 2011

On episode #13 of the podcast This Week in Microbiology, Stanley, Jo, Michael and Elio discuss how colonic microbial ecology and risk for colitis are regulated by an inflammasome, and amelioration of intestinal inflammation in mice by delivery of a p...Show More
TWiM #12: Photothermal nanoblades and genome engineering

1:15:23 | Jul 27th, 2011

Vincent, Margaret, Michael and Elio review the use of photothermal nanoblades to dissect the Burkholderia intracellular life cycle, and manipulation of chromosomes in vivo for genome-wide codon replacement in E. coli.
TWiM #11: Chickens, antibiotics, and asthma

1:12:40 | Jul 13th, 2011

Vincent, Margaret, Michael and Elio review the presence of extended spectrum beta-lactamase genes in chicken meat and in humans, and a beneficial effect of Helicobacter pylori colonization on the development of allergen-induced asthma.
TWiM #10: A symbiotic cloaking device

1:08:07 | Jun 29th, 2011

On episode #10 of the podcast This Week in Microbiology, Vincent, Margaret, Elio, Michael and Dickson discuss the symbiosis between the Hawaiian bobtail squid and the luminous, gram-negative bacterium Vibrio fischeri.
TWiM #9: Bean sprouts and E. coli O104:H4

1:16:35 | Jun 15th, 2011

Vincent, Michael, and Cliff review the outbreak of bloody diarrhea and hemolytic uremic syndrome in Germany caused by Shiga toxin-producing Escherichia coli O104:H4.
TWiM # 8: Live in NOLA

1:26:21 | Jun 1st, 2011

Vincent, Michael, and Stanley recorded TWiM #8 live at the 2011 ASM General Meeting in New Orleans, with guests Andreas Baümler, Nicole Dubilier, and Paul Rainey. They spoke about how pathogens benefit from disease, symbioses between chemosynthetic b...Show More
TWiM #7: Cycles of life and death, light and dark

1:04:09 | May 18th, 2011

Vincent, Cliff, Elio, Margaret, and Michael discuss programmed cell death in E. coli, and the daily synthesis and degradation of enzymes needed for photosynthesis and nitrogen fixation by cyanobacteria.
TWiM #6: Antibacterial therapy with bacteriophage: Reality or fiction?

1:22:11 | May 4th, 2011

Vincent, Cliff, Michael and Elio review the use of bacteriophages to manage infections, and the presence of antibiotic resistance genes in the bacteriophage from urban sewage and river water.
TWiM #5: Mercury-methylating Desulfovibrio and antimicrobial nanoparticles

1:15:51 | Apr 20th, 2011

Vincent, Ron, Cliff, and Michael discuss the genome sequence of a mercury-methylating bacterium and the antimicrobial effects of nanoparticles.
TWiM #4: Cantaloupes and Salmonella gastroenteritis

1:14:45 | Apr 6th, 2011

Vincent, Cliff, Margaret, and Michael review foodborne bacterial illness in the context of outbreaks associated with cantaloupes and Lebanon bologna.
TWiM #3: Anthrax, genomics and the FBI inquiry

1:00:27 | Mar 23rd, 2011

Vincent, Jo, Cliff, and Ron explore the genome analysis done in support of the Amerithrax investigation, and an insecticidal enterotoxin-deficient mutant of Bacillus thurigiensis.
TWiM #2: The plague, microbial virulence and the gut microbiome

1:15:43 | Mar 9th, 2011

Vincent, Cliff, and Michael review a fatal laboratory acquired Yersinia pestis infection, and how gut bacteria control body weight and metabolic activity.
TWiM #1: Neisseria LINEs up

1:03:23 | Feb 23rd, 2011

On episode #1 of the podcast This Week in Microbiology, Vincent, Cliff, Michael, and Stan discuss transfer of DNA from a human host to a bacterial pathogen, and the ability of dry copper to kill bacteria on contact.