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Medical Breakthroughs from Penn Medicine

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Medical Breakthroughs features the newest medical advancements in the areas of oncology, cardiology, neurosciences, orthopedics, and genetics featuring America’s leading physicians and medical researchers from Penn Medicine. In Partnership with
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Endeavors of the Heart: Leveraging Innovative Technologies for Transcatheter Therapies

0:00 | May 3rd

Host: Matt Birnholz, MD Guest: Howard C. Herrmann, MD Twelve years after performing the first transcatheter aortic valve replacement, Penn Medicine continues to gain momentum in the transformation of cardiovascular transcatheter therapies. Dr....Show More
Reinventing Autologous Breast Reconstruction to Reduce Pain and Postsurgical Opioid Use

0:00 | Jan 14th

Host: Jennifer Caudle, DO Guest: Suhail K. Kanchwala, MD Improving his patients’ post-surgical experience was Dr. Suhail Kanchwala's goal when he sought to develop a new method for autologous breast reconstruction. The result of his search has...Show More
Are VADs the Answer to the Heart Failure Epidemic?

0:00 | Jun 8th, 2018

Host: Jennifer Caudle, DO Guest: Eduardo Rame, MD Following a successful ventricular assist device clinical trial, Dr. Jennifer Caudle is joined by Dr. Eduardo Rame, Cardiologist at the Hospital of the University of Pennsylvania, to discuss ho...Show More
FDA-Approved Gene Therapy Reverses Blindness in Children & Adults

0:00 | Apr 23rd, 2018

Host: Jennifer Caudle, DO Guest: Jean Bennett, MD, PhD Guest: Albert Maguire, MD Power couple Drs. Jean Bennett and Albert Maguire discuss how their new therapy for the RPE65 gene, which causes retinal blindness, was recently approved by the...Show More
When Your Patient Has a Spinal Deformity: Clinical Priorities

0:00 | Feb 2nd, 2018

Host: Barnett Mennen, MD Guest: Comron Saifi, MD Spinal deformity places strain on the vertebrae and supporting muscles, tendons, ligaments, and tissues supporting the spinal column. The treatment and management of this condition becomes centr...Show More
What to Know About a State-of-the-Art Approach to GIST Treatment

0:00 | Jan 17th, 2018

Host: Shira Johnson, MD Guest: Ronald DeMatteo, MD, FACS A Gastrointestinal Stromal Tumor (GIST) is a rare sarcoma that begins in the digestive tract or stomach, with an incident rate in the United States of approximately 4,000 to 6,000 cases ...Show More
CAR-T Cell Therapy: A Breakthrough Treatment for Fighting Cancer

0:00 | Oct 23rd, 2017

Host: Shira Johnson, MD Guest: Robert Vonderheide, MD For years, the foundations of cancer treatment, surgery, chemotherapy, and radiation therapy were utilized with the objective of weakening cancer. But over the past several years, immunothe...Show More
Unclog the Arteries: Treatment Options for Arterial Disease

0:00 | Jun 7th, 2017

Host: Barnett Mennen, MD Guest: Grace Wang, MD, FACS Unclogging patient arteries is a key step to preventing stroke in patients with arterial disease. Whether it be preventing the operative stage, or surgery itself, advances in treatment at Pe...Show More
Pancreatic Cancer: Associated Signs, Symptoms, Risk Factors and Treatment Approaches

0:00 | May 23rd, 2017

Host: Jennifer Caudle, DO Guest: Major Kenneth Lee, IV, MD, PhD Though a relatively rare disease, pancreatic cancer remains at the forefront of clinical discussion due to its highly aggressive nature. Dr. Major Kenneth Lee, Assistant Professor...Show More
Hepatitis C Virus (HCV): Current Screening Guidelines and Treatment Approaches

0:00 | May 3rd, 2017

Host: Jennifer Caudle, DO Guest: Vincent Lo Re, MD, MSCE In 2014, the CDC estimated a total of 2,194 cases of acute hepatitis across 40 states and estimates that 2.7-3.9 million people in the United States have chronic hepatitis C. Of every 10...Show More
Hot Topics in Breast Cancer Innovations

0:00 | Feb 6th, 2017

Host: Matt Birnholz, MD Guest: Ari Brooks, MD Guest: Brian Englander, MD Host Dr. Matt Birnholz is joined by Dr. Ari Brooks, Director of Endocrine and Oncology Surgery and Director of the Integrated Breast Center at Pennsylvania Hospital, an...Show More
Hot Topics in Counseling Patients Who are Trying to Conceive

0:00 | Feb 6th, 2017

Host: Matt Birnholz, MD Guest: Robert H. Debbs, DO Joining Dr. Matt Birnholz to discuss counseling methods for patients who are trying to conceive is Dr. Robert Debbs, Director of the Pennsylvania Hospital Maternal Fetal Medicine Network in Ne...Show More
A Thoracic Surgeon's Viewpoint on Screening, Diagnosis and Treatment of a Lung Cancer Patient

0:00 | Feb 2nd, 2017

Host: Matt Birnholz, MD Guest: Taine Pechet, MD Dr. Taine Pechet, chief of surgery at Penn Presbyterian Medical Center and associate professor of clinical surgery at Penn Medicine joins host Dr. Matt Birnholz to discuss his thoughts on who sho...Show More
Full Spectrum of Breast Reconstruction Surgeries: From Cosmetic to Breast Cancer Diagnosis

0:00 | Feb 2nd, 2017

Host: Matt Birnholz, MD Guest: Paris D. Butler, MD, MPH Host Dr. Matt Birnholz welcomes Dr. Paris D. Butler, who will be discussing breast reduction surgery for women who suffer from chronic back pain and breast cancer patients undergoing reco...Show More
Curing Blindness: How Researchers are Utilizing Gene Therapy

0:00 | Jan 5th, 2017

Host: Shira Johnson, MD Guest: Jean Bennett, MD, PhD There are 39 million people worldwide who are in total blindness and another 246 million with very low vision. The most frequent forms of visual impairment are caused by problems that can be...Show More
Cranial Base Disorders: Etiologies, Surgical Approaches, and Research Innovations

0:00 | Oct 10th, 2016

Host: Matt Birnholz, MD Guest: John Y.K. Lee, MD Guest: Jason G. Newman, MD, FACS Joining Dr. Matt Birnholz to discuss innovative surgical approaches to cranial base disorders are Doctors John Y. K. Lee and Jason G. Newman. Dr. Lee is Medica...Show More
Groundbreaking Child Bilateral Hand Transplant

0:00 | Jul 4th, 2016

Host: Shira Johnson, MD For the first time, Penn Medicine surgeons were able to complete a bilateral hand transplant on a child. The surgical team successfully transplanted donor hands and forearms onto 8-year-old Zion Harvey who, several years ...Show More
Who is at Risk for Pulmonary Arterial Hypertension (PAH)?

0:00 | Jun 27th, 2016

Host: Jennifer Caudle, DO Guest: K. Akaya Smith, MD Pulmonary Arterial Hypertension (PAH): Who is at greatest risk for developing it? What do practitioners need to know about diagnosing, treatment and the overall prognosis? Host Dr. Jennifer C...Show More
PVC Ablation Procedures for Ventricular Tachycardia

0:00 | Jun 13th, 2016

Host: Jennifer Caudle, DO Guest: Francis Marchlinski, MD Host Dr. Jennifer Caudle welcomes Dr. Francis E. Marchlinski, Richard T. and Angela Clark President's Distinguished Professor and Director of the Electrophysiology Laboratory at the Univ...Show More
Chronic Deep Vein Thrombosis (DVT) and Post Thrombotic Syndrome (PTS): What Physicians Need to Know

0:00 | May 16th, 2016

Host: Barnett Mennen, MD Guest: Deepak Sudheendra, MD, FSIR, RPVI Host Dr. Barry Mennen joins Dr. Deepak Sudheendra, Assistant Professor of Clinical Radiology & Surgery at the Hospital of the University Of Pennsylvania Perelman School Of Medic...Show More
Peripheral Arterial Disease (PAD): Revascularization for Clinical Limb Ischemia

0:00 | May 9th, 2016

Host: Jennifer Caudle, DO Guest: Timothy W.I. Clark, MD Host Dr. Jennifer Caudle welcomes Dr. Timothy Clark, Associate Professor of Clinical Radiology and the Director of Interventional Radiology at Penn Presbyterian Medical Center. Dr. Clark ...Show More
Bridging The Cardiology Gap: Care Priorities for Adults With Congenital Heart Disease

0:00 | Apr 25th, 2016

Host: Jennifer Caudle, DO Guest: Yuli Kim, MD Advancements in cardiac surgery and medical care for pediatric patients over the past decades have produced a sizeable population of adults living with congenital heart disease. These adults and th...Show More
Addressing Breast Cancer's High Recurrence Rates: The Breast Cancer Translational Center of Excellence (TCE)

0:00 | Apr 18th, 2016

Host: Barnett Mennen, MD Guest: Angela DeMichele, MD, MSCE Penn Medicine’s Breast Cancer Translational Center of Excellence (TCE), known as the 2-PREVENT TCE is led by Drs. Lewis Chodosh and Angela DeMichele. 2-PREVENT TCE aims to address one ...Show More
Complex Aortic Disease: Sussing Out a Silent Killer to Save Lives

0:00 | Apr 4th, 2016

Host: Jennifer Caudle, DO Guest: Nimesh Desai, MD Complex aortic diseases, feared by clinicians and the general public alike, are often labeled "silent killers" due to their unnerving pattern for developing insideously prior to presenting as a...Show More
The Next Horizons in Reconstructive Microsurgery

0:00 | Mar 28th, 2016

Host: Shira Johnson, MD Guest: Joseph M. Serletti MD Reconstructive microsurgery, where specialized operating microscopes and precision instrumentation are utilized to perform intricate operations in very small fields, is a rapidly evolving sp...Show More
The Science of Making Tumors Glow: Innovations from the Center for Precision Surgery

0:00 | Mar 24th, 2016

Host: Shira Johnson, MD Guest: Sunil Singhal, MD The clinical ramifications for adding special fluorescent features to tumors at various stages of malignancy and penetration are enormous. But how do surgical, oncologic, and radiological specia...Show More
Hepatocellular Carcinoma: Clinical Priorities from Detection to Liver Transplantation

0:00 | Mar 18th, 2016

Host: Barnett Mennen, MD Guest: Maarouf Hoteit, MD Hepatocellular carcinoma is one of the top ten causes of cancer death in the United States, and is the most rapidly increasing cause of cancer death in men. What's more, incidence rates are on...Show More
How The Tommy John Surgery Revolutionized Elbow Injury Rehabilitation

0:00 | Feb 22nd, 2016

Host: Jennifer Caudle, DO Guest: G. Russell Huffman, MD, MPH Host Dr. Jennifer Caudle welcomes Dr. G. Russell Huffman, Associate Professor and Director of the Shoulder and Elbow Fellowship at the University of Pennsylvania. Dr. Huffman provide...Show More
The Nuts & Bolts of Treating Articular Cartilage Defects

0:00 | Feb 1st, 2016

Host: Jennifer Caudle, DO Guest: James L. Carey, MD, MPH What happens when articular cartilage is damaged? And what are the differences between focal cartilage defects and arthritis? Joining Dr. Jennifer Caudle to discuss current mechanistic u...Show More
Orthopaedic Trauma: Healing Bones & Restoring Function

0:00 | Jan 18th, 2016

Host: Brian P. McDonough, MD, FAAFP Guest: Samir Mehta, MD Patients of all ages can be affected by a traumatic injury. These injuries can be complex to treat and may involve multiple parts of the body. And, in traumatic situations, decisions n...Show More
The Path to Lung Transplantation: Roles of Extracorporeal Membrane Oxygenation (ECMO)

0:00 | Jan 11th, 2016

Host: Jennifer Caudle, DO Guest: Christian A. Bermudez, MD Christian A. Bermudez, MD is the Surgical Director of Lung Transplantation and ECMO, Director of Thoracic Transplantation, and Associate Professor of Surgery at the Hospital of the Uni...Show More
Complex Retrieval of Embedded Inferior Vena Cava Filters in Interventional Radiology

0:00 | Jan 4th, 2016

Host: Jennifer Caudle, DO Guest: Scott O. Trerotola, MD, FACR, FSIR Is there a way to predict complex removal of inferior vena cava filters, and if so, what is the success rate? Dr. Scott Trerotola adresses these and other questions in details...Show More
Applications of Proton Therapy for Breast Cancer

0:00 | Dec 14th, 2015

Host: Jennifer Caudle, DO Guest: Gary M. Freedman, MD Proton therapy is currently used to treat brain, spinal and prostate cancers, as well as many other tumors. Another potentially significant application is the treatment of breast cancer. Dr...Show More
Modernizing the Mitral Valve: Advances in Robotic and Minimally Invasive Cardiac Repair

0:00 | Oct 12th, 2015

Host: Jennifer Caudle, DO Guest: Pavan Atluri, MD What are the latest advances in minimally invasive & robotic operations? And, which patients are candidates for robotic procedures? Host Dr. Jennifer Caudle welcomes Dr. Pavan Atluri, Assistant...Show More
The Role of Technology in Precision Medicine

0:00 | Jul 13th, 2015

Host: Frank Russomano There are far too many diseases that do not have proven means of prevention or effective treatments. As such, health care providers must gain better insights into the biology of these diseases to make a difference for the m...Show More
Innovations in Facial Reconstruction

0:00 | Mar 9th, 2015

Host: Lee Freedman, MD When a patient's facial structures are severely impacted by trauma or disease, the physical and psychological tolls are devastating. What are some of the latest advances in facial reconstruction? Joining Dr. Lee Freedman a...Show More
Sexual Function and Fertility in Men After Cancer

0:00 | Mar 2nd, 2015

Host: Lee Freedman, MD Given the multitude of concerns a male patient with cancer must deal with, sexual dysfunction and infertility are two such concerns that often gets bypassed by clinicians addressing more "priority" issues. What kinds of ch...Show More
Osteosarcoma: Clinical Priorities for Recognition and Treatment

0:00 | Feb 16th, 2015

Host: Lee Freedman, MD Osteosarcoma is a relatively rare but feared disease. What exactly is an osteosarcoma and how should it be worked up and treated? Host Dr. Lee Freedman discusses this diagnosis with Dr. Kristy Weber, Abramson Family Profes...Show More
Innovative Options for Patients with Multiple Myeloma

0:00 | Feb 9th, 2015

Host: Lee Freedman, MD Multiple myeloma (MM) is an incurable malignancy of plasma cells. Although there have been significant advances in the survival of this condition over the past 15 years, understanding the progression from its precursor sta...Show More
The Use of TORS for HPV-Related Oropharynx Cancer

0:00 | Feb 2nd, 2015

Host: Lee Freedman, MD Oropharyngeal cancer is part of a growing proportion of head and neck malignancies. This has also been associated with the increase in infection of the oropharynx by oncogenic strains of the human papillomavirus (HPV). And...Show More
Cerebrovascular Neurosurgery: The Highly Specialized Care for All Aspects of Cerebrovascular Disease

0:00 | Jan 26th, 2015

Host: Lee Freedman, MD Cerebrovascular Neurosurgery is the highly specialized care for all aspects of cerebrovascular disease. What are the most common diseases treated by a cerebrovascular neurosurgeon? What are the latest treatment options and...Show More
Laparoscopic Surgical Approaches for Ulcerative Colitis

0:00 | Dec 22nd, 2014

Host: Lee Freedman, MD Patients with ulcerative colitis often need to take multiple medications to achieve and sustain remission. But there is a pionering surgical approach, the laparoscopic J-pouch procedure, that can not only cure patients fro...Show More
Advances in Electrophysiology (EP) Procedures

0:00 | Oct 2nd, 2014

Host: Lee Freedman, MD Host Dr. Lee Freedman is joined by Francis Marchlinski, MD, Director of Electrophysiology at the University of Pennsylvania Health System; and, the Director of Electrophysiology Laboratory, Hospital of the University of Pe...Show More
Heated Intraperitoneal Chemotherapy (HIPEC) for Advanced Abdominal Cancers

0:00 | Oct 2nd, 2014

Host: Lee Freedman, MD Heated/Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is one of the most innovative treatments available today for complex abdominal cancers. What is it? Who is a candidate? And, what are the expected outcomes for our p...Show More
Innovations in Vascular Surgery

0:00 | Oct 2nd, 2014

Host: Lee Freedman, MD How does surgery and stenting for carotid lesions help prevent stroke? What are the latest approaches, clinical trials, and philosophy for dialysis access for patients? Host Dr. Lee Freedman welcomes Dr. Benjamin Jackson t...Show More
Surgical Options for Spinal Disorders

0:00 | Oct 2nd, 2014

Host: Lee Freedman, MD Joining host Dr. Lee Freedman is William C. Welch, MD, FACS, FICS, Professor of Neurosurgery and Professor of Orthopaedic Surgery, and Vice Chair of the Department of Neurosurgery at Pennsylvania Hospitall. Dr. Welch will ...Show More
A Focus on Hip Preservation in Younger Patients

0:00 | Oct 2nd, 2014

Host: Lee Freedman, MD Hip pain can be a major roadblock to an active lifestyle, and even effect activies of daily living. This is sometimes even more profound when seen in younger patients. How can we preserve hip function in younger patients, ...Show More
Exploring Pituitary Tumors: Diagnostic Considerations and Advanced Therapies

0:00 | Oct 2nd, 2014

Host: Lee Freedman, MD According to the American Cancer Society, about 10,000 pituitary tumors are diagnosed each year in the United States. What is the state of the art approach to the diagnosis and treatment of these tumors? Dr. Lee Freedman t...Show More
Understanding Musculoskeletal Tumors

0:00 | Oct 2nd, 2014

Host: Lee Freedman, MD Presentation of lumps and bumps are common in the primary care setting, but the appropriate approach is vital to determine whether there may be a deeper problem. A better understanding can lead to more effective treatment....Show More
New Advances in Head & Neck Cancers at Penn Medicine

0:00 | May 15th, 2014

Host: Lee Freedman, MD What are the new advances in Head and Neck Cancer? What are the new trials in sparing patients' voice box? To answer these questions and more, host Dr. Lee Freedman is joined by radiation-oncologist Alexander Lin, MD, Assi...Show More
Personalized Diagnostics & Targeted Therapies

0:00 | Apr 25th, 2014

Host: Lee Freedman, MD The Philadelphia Chromosome provided the first evidence that genetic abnormalities were linked to cancer. This discovery at Penn Medicine more than 50 years ago ushered in the modern period of cytogenetics. Now, the Center...Show More
Surgical and Medical Advances from the Brain Tumor Center

0:00 | Jan 1st, 2014

Host: Lee Freedman, MD Brain tumors invoke great fear in the general populace, such that many patients interpret being diagnosed with brain cancer as akin to receiving immediate death sentences. But significant progress has been made in the diag...Show More
The Future of Deep Brain Stimulation for Parkinson's Patients and Beyond

0:00 | Jan 1st, 2014

Host: Lee Freedman, MD Host Dr. Lee Freedman welcomes Dr. Gordon Baltuch, Director of the Center for Functional and Restorative Neurosurgery and Professor of Neurosurgery at the Hospital of the University of Pennsylvania. Dr. Baltuch discusses t...Show More
The Latest on Ocular Gene Therapy

0:00 | Nov 26th, 2011

Host: Lee Freedman, MD Guest: Jean Bennett, MD, PhD Host Dr. Lee Freedman and Dr. Jean Bennett, the FM Kirby Professor of Epistemology at the University of Pennsylvania School of Medicine, explore how the study of molecular genetics of inherit...Show More
Neurosurgical Quality Improvement Measures & Patients With Degenerative Disc Disease

0:00 | Aug 31st, 2011

Host: Lee Freedman, MD Guest: Neil Malhotra, MD How much do quality improvement efforts improve quality of life for neurosurgical patients? Host Dr. Lee Freedman talks to Dr. Neil Malhotra, assistant professor of neurosurgery at the University...Show More
Recent Advances in the Identification and Treatment of Aortic Disease

0:00 | Jun 9th, 2011

Host: Lee Freedman, MD Guest: Grace Wang, MD, FACS Dr. Grace Wang, vascular surgeon in the division of vascular and endovascular surgery at Penn Medicine, discusses aortic disease from a surgeon's perspective, with host Dr. Lee Freedman. Among...Show More
Bladder Cancer Treatment and Preserving Quality of Life

0:00 | May 27th, 2011

Host: Lee Freedman, MD Guest: Thomas Guzzo, MD, MPH With 70,000 new cases each year in the US, bladder cancer is more common than many Americans may realize. As many as half of cases are caused by smoking, and many others are caused by environ...Show More
Hearing Restoration Surgery & Cochlear Implants

0:00 | Apr 29th, 2011

Host: Lee Freedman, MD Guest: Michael Ruckenstein, MD In this week's Medical Breakthroughs from Penn Medicine, Dr. Michael Ruckenstein, director of the Center for Implantable Hearing Devices at Penn Medicine, discusses with host Dr. Lee Freedm...Show More
TORS for Sleep Apnea

0:00 | Apr 25th, 2011

Host: Lee Freedman, MD Guest: Erica Thaler, MD Sleep apnea is becoming more prevalent in the population, and there are many treatment options. Host Dr. Lee Freedman talks with Dr. Erica Thaler, director of the division of otorhinolaryngology: ...Show More
Endoscopic Brain Surgery, In 3-D

0:00 | Apr 25th, 2011

Host: Lee Freedman, MD Guest: John Y.K. Lee, MD 3-D technology is making its way from the movies, into the operating room. How is this technology enhancing brain surgeries? Dr. John Y.K. Lee, medical director of the Penn Gamma Knife Center and...Show More
Advantages of Bloodless Medicine

0:00 | Apr 19th, 2011

Guest: Patricia Ford, MD Host: Lee Freedman, MD Patients may choose bloodless medicine for either medical or ethical reasons. How safe and effective are bloodless procedures, compared to more traditional approaches? Dr. Patricia Ford, clinical...Show More
Adolescent Reproductive Health Conditions and Fertility Preservation

0:00 | Aug 2nd, 2010

Guest: Suleena Kalra, MD Host: Lee Freedman, MD Primary and secondary amenorrhea can have various underlying causes among adolescents, including polycystic ovarian syndrome (or PCOS), thyroid disease, and atypical body weight. What types of be...Show More
An Update on Common Esophageal Disorders

0:00 | Jul 26th, 2010

Guest: Gary Falk, MD Host: Lee Freedman, MD Millions of Americans have esophageal disorders, ranging in severity from gastroesophogeal reflux (or GERD) to eosinophilic esophagitis to esophageal cancer. A diet rich in acidic or fatty foods can ...Show More
Pregnancy and Heart Disease: Minimizing Risks

0:00 | Jun 23rd, 2010

Guest: Nazanin Moghbeli, MD, MPH Host: Lee Freedman, MD How can physicians assess and minimize the risk for women with existing heart disease prior to pregnancy? As many women are waiting longer to become pregnant, is the spectrum of cardiovas...Show More
The Advantages and Future of Capsule Endoscopy

0:00 | Jun 16th, 2010

Guest: Nuzhat Ahmad, MD Host: Lee Freedman, MD Although capsule endoscopy has been used since the start of the new millennium, the technology is still evolving and improving. Capsule endoscopy can help gastroenterologists visualize abnormaliti...Show More
Options in Breast Reconstructive Microsurgery

0:00 | May 13th, 2010

Guest: Joseph Serletti, MD Host: Lee Freedman, MD How are the latest advances in autogenous breast reconstruction changing the landscape of options available to women after mastectomy? Dr. Joseph Serletti, the Henry Royster - William Maul Meas...Show More
Surgical Procedures for Complex Frontal Sinus Disease

0:00 | May 7th, 2010

Host: Lee Freedman, MD Guest: James Palmer, MD Sinusitis can be debilitating. Complex frontal sinus disease may be categorized as infectious, or due to tumors or trauma. When frontal sinus disease is refractory to medical management, what type...Show More
Current Research on Preterm Birth

0:00 | Mar 9th, 2010

Guest: Michal Elovitz, MD Host: Lee Freedman, MD The preterm birth rate in the United States is increasing, despite efforts to expand research and studies in this area. What are some of the risk factors for preterm birth, and are there any way...Show More
Microsurgical Techniques for Limb Salvage

0:00 | Mar 2nd, 2010

Guest: Scott Levin, MD Host: Lee Freedman, MD Trauma patients with injury to one or more limb often have additional systemic injuries that need to be considered during treatment. One approach to limb salvage is the ortho-plastic technique, whi...Show More
Advances in Preimplantation Genetic Diagnosis

0:00 | Mar 2nd, 2010

Guest: Anuja Dokras, MD, PhD Host: Lee Freedman, MD In what situations do couples consider preimplantation genetic diagnosis, or PGD, and should all of these couples undergo genetic counseling prior to PGD? What is the process for PGD? How acc...Show More
The Future of Proton Therapy

0:00 | Aug 10th, 2009

Guest: James Metz, MD Host: Lee Freedman, MD Proton therapy has existed for decades, but it's only recently begun to be clinically adopted. Rather than being a stand-alone treatment, this therapy is often best used in conjunction with surgery ...Show More
The Role of Proton Therapy for Primary Bone Cancer and Spinal Metastasis

0:00 | Jul 28th, 2009

Guest: Michelle Alonso-Basanta, MD, PhD Host: Lee Freedman, MD What are the limitations of conventional treatment for primary bone cancer and spinal metastasis? How can proton therapy be particularly beneficial for treating primary bone tumors...Show More
Proton Therapy for Brain Tumors

0:00 | Jul 20th, 2009

Guest: Robert Lustig, MD Host: Lee Freedman, MD What advantages are there to using proton therapy to treat brain tumors? Is proton therapy most effective when used alone or when it is integrated with conventional radiation therapy? What patien...Show More
Novel Approaches to Bone Marrow and Stem Cell Transplant

0:00 | Jun 11th, 2009

Guest: David Porter, MD Host: Lee Freedman, MD The conventional bone marrow transplant procedure can have many side effects, and the traditional procedure can be especially risky for older patients or other patients with comorbidities. How are...Show More
Novel Adjuvant Therapies for Lung Cancer

0:00 | Jun 8th, 2009

Guest: John Kucharczuk, MD Host: Lee Freedman, MD Lung cancer is one of the most fatal types of cancer, but significant advances are being made. How are novel adjuvant post-operative therapies, including personalized therapies, improving survi...Show More
Diagnosing Gastrointestinal Neuroendocrine Tumors

0:00 | Jun 5th, 2009

Guest: David Metz, MD Host: Lee Freedman, MD Although gastroenteropancreatic neuroendocrine tumors, or GEP-NETs, are relatively common, they are often indolent. However, GEP-NETs can metastasize in a small portion of the population, so physici...Show More
Awake Craniotomy and Mapping Techniques for Brain Tumor Surgery

0:00 | May 29th, 2009

Guest: Donald O'Rourke, MD Host: Lee Freedman, MD Awake craniotomy offers many advantages to brain tumor surgery, since it allows neurosurgeons to maximize surgical resection, while minimizing neurologic risks. Is this procedure well tolerated...Show More
Cellular Vaccine Development as Cancer Therapy

0:00 | May 28th, 2009

Guest: Don Siegel, MD, PhD Host: Lee Freedman, MD What are cellular vaccines and how do they differ from what we think of as conventional vaccines? What are the various types of approaches that we can potentially use for inducing anti-cancer i...Show More
The Link Between Psoriasis and Cardiac Conditions

0:00 | May 14th, 2009

Guest: Joel Gelfand, MD Host: Lee Freedman, MD Are patients with psoriasis more likely to develop cardiovascular disease, and what mechanisms might link these two conditions? Do the severity of psoriasis and the agents used to treat this condi...Show More
Beyond Dry Eyes: Signs of Sjogren's Syndrome

0:00 | Dec 8th, 2008

Host: Lee Freedman, MD Guest: Frederick Vivino, MD Sjogren's syndrome is a commonly overlooked autoimmune disorder. Dry eyes and whole-body dryness are just two of the symptoms of Sjogren's syndrome that can suggest other conditions as well. H...Show More
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

0:00 | Dec 5th, 2008

Guest: Andrew Haas, MD, PhD Host: Lee Freedman, MD Until recently, bronchoscopy has involved using cameras with CT guidance to determine abnormalities along the airway and lymph nodes. How is ultrasound now being used for bronchoscopic needle ...Show More
Prostatic Cryosurgery and Robotic Prostatectomy

0:00 | Dec 5th, 2008

Host: Lee Freedman, MD Guest: David I. Lee, MD Newer options for treating prostate cancer include cryosurgery and robotic prostatectomy. What does each of these methods involve and how can we determine the best treatment for our patients? Dr. ...Show More
The Biomechanical Approach to Heart Disease

0:00 | Nov 13th, 2008

Guest: Joseph Gorman III, MD Host: Lee Freedman, MD Many cardiovascular researchers consider the heart from a biochemical or genetic standpoint, but what are the advantages to a biomechanical approach? Dr. Joseph Gorman, associate professor of...Show More
Incisionless Brain Surgery

0:00 | Nov 6th, 2008

Guest: Jason G. Newman, MD, FACS Host: Lee Freedman, MD Minimally-invasive surgery is generally an attractive option, but how reliable and effective is brain surgery performed through the nose? Dr. Jason Newman, assistant professor of otolaryn...Show More
When a Fracture is More Than a Fracture

0:00 | Aug 14th, 2008

Host: Lee Freedman, MD Guest: Samir Mehta, MD Dr. Samir Mehta, chief of orthopedic trauma at the Hospital of the University of Pennsylvania, discusses the role of the orthopedic traumatologist. What does this designation mean? What kind of spe...Show More
Benign Prostatic Hyperplasia: GreenLight for Laser Therapy?

0:00 | Aug 13th, 2008

Guest: Joseph Harryhill, MD Host: Lee Freedman, MD Dr. Joseph Harryhill, assistant clinical professor of surgery at the University of Pennsylvania School of Medicine, outlines procedural considerations for men with benign prostatic hyperplasia...Show More
Investigational Approaches to Structural and Valvular Heart Disease

0:00 | Aug 5th, 2008

Guest: Howard C. Herrmann, MD Host: Lee Freedman, MD We are increasingly able to turn to non-surgical therapies for structural and valvular heart disease. Host Dr. Lee Freedman discusses investigational, catheter-based treatment with Dr. Howar...Show More
Comprehensive Smoking Cessation Programs

0:00 | Jul 25th, 2008

Guest: Frank Leone, MD Host: Lee Freedman, MD Smoking-related morbidities and health complications are well-established. Even with social trends impinging on the freedom to smoke in convenient locations, many of our patients still can't kick t...Show More
Smoking Cessation Therapies

0:00 | Jul 25th, 2008

Guest: Frank Leone, MD Host: Lee Freedman, MD The morbidities and health complications from smoking are certainly well established. But even with social trends increasingly making the life of a smoker more difficult, many of our patients still...Show More
Practice and Potential of Deep Brain Stimulation

0:00 | Jul 23rd, 2008

Guest: Gordon Baltuch, MD, PhD Host: Lee Freedman, MD Known as the ‘pacemaker for the brain,' deep brain stimulation has made noteworthy progress in treating Parkinson's disease. Dr. Gordon Baltuch, associate professor of neurosurgery and dire...Show More
Image-Guided Surgery

0:00 | Jul 8th, 2008

Guest: Craig Israelite, MD Host: Lee Freedman, MD In surgery, we strive for less invasive procedures that still allow for the greatest precision possible. Developments in image-guided surgery are helping us meet this goal. Dr. Craig Israelite,...Show More
Approaching Vulnerable Plaque in the Coronaries

0:00 | May 30th, 2008

Host: Lee Freedman, MD Guest: Emile Mohler III, MD How should we approach vulnerable plaques in the coronaries and how can we calculate more precise risk levels in both high- and average-risk patients? Host Dr. Lee Freedman addresses diagnosis...Show More
Addressing Vascular Plaque Ruptures

0:00 | May 30th, 2008

Host: Lee Freedman, MD Guest: Emile Mohler III, MD A ruptured vascular plaque with subsequent thrombus often triggers the heart attack that occurs without warning. How do we identify and treat at-risk cardiac patients? Host Dr. Lee Freedman di...Show More
Melanoma Basics: Are You Up To Date?

0:00 | Feb 14th, 2008

Guest: Christopher Miller, MD Host: Lee Freedman, MD Dr. Miller reviews basic and newer understandings about melanomas---how do they arise, what are risk factors, how are they recognized and diagnosed?
Lumbar Spinal Stenosis: Think Surgery?

0:00 | Jan 25th, 2008

Guest: William Welch, MD Host: Lee Freedman, MD Dr. Welch reviews the approach to this common and disabling condition that affects our older patients. He reviews the diagnosis and initial treatment of lumbar spinal stenosis and then discusses ...Show More
New Surgical Options for Spinal Disorders

0:00 | Jan 25th, 2008

Guest: William Welch, MD Host: Lee Freedman, MD Advancing surgical treatments and devices are producing better outcomes for patients with spinal problems. How do these innovations alleviate pain associated with spinal stenosis, spinal metastas...Show More
Surgical Advances in Knee Osteoarthritis

0:00 | Jan 24th, 2008

Host: Lee Freedman, MD Guest: Craig Israelite, MD Dr. Craig Israelite, assistant professor of orthopedic surgery at the University of Pennsylvania School of Medicine, discusses a series of approaches to knee osteoarthritis. A brief review of n...Show More
Surgical Breakthroughs In Hip Osteoarthritis

0:00 | Jan 24th, 2008

Host: Lee Freedman, MD Guest: Craig Israelite, MD Dr. Israelite intially reviews some basic concepts in the approach to osteoarthritis. He then outlines recent surgical advances in the treatment of osteoarthritis of the hip that have led to be...Show More
Overuse Tendon Injuries: New Approaches

0:00 | Nov 19th, 2007

Guest: Louis Soslowsky, PhD Host: Lee Freedman, MD Dr. Louis Soslowsky, from the University of Pennsylvania Health System, outlines how newer understanding of the mechanism of injury in overuse syndromes is leading to new approaches in treatme...Show More
Rotator Cuff Tears: New Understandings

0:00 | Nov 19th, 2007

Guest: Louis Soslowsky, PhD Host: Lee Freedman, MD Dr. Soslowsky discusses how new understandings of the pathophysiology of tendon-to-bone repair are leading to a new therapeutic approach to rotator cuff tears.
Alzheimer's Disease: What Does the Future Hold?

0:00 | Oct 17th, 2007

Guest: John Trojanowski, MD, PhD Host: Lee Freedman, MD Dr. Trojanowski discusses the implications of our aging population in terms of the future burden of Alzheimer's disease: financial and human costs. He then reviews newer directions for th...Show More
Differentiating the Dementias

0:00 | Oct 17th, 2007

Guest: John Trojanowski, MD, PhD Host: Lee Freedman, MD Dr. Trojanowski discusses how to differentiate the types of dementia and how making these distinctions can lead to different approaches in terms of management.
Novel Treatments for Diabetes

0:00 | Oct 12th, 2007

Guest: Mitchell Lazar, MD, PhD Host: Lee Freedman, MD Dr. Lazar discusses exciting new innovations in our approach to both type I and type II diabetes including Islet cell transplantation, medications for beta cell preservation and new insight...Show More
The Diabetes Epidemic

0:00 | Oct 12th, 2007

Guest: Mitchell Lazar, MD, PhD Host: Lee Freedman, MD The CDC has ominously projected that one in three children born in the year 2000 will develop diabetes in his or her lifetime. Mitchell Lazar, MD, PhD, professor of medicine and genetics at...Show More
Pacemaker for the Brain

0:00 | Oct 12th, 2007

Guest: John Y.K. Lee, MD Host: Lee Freedman, MD Dr. Lee discusses the use of Deep Brain Stimulation as a new option for the treatment of Parkinsonian tremor and other movement disorders.
The Gamma Knife: Safer, More Precise Treatment

0:00 | Oct 12th, 2007

Guest: John Y.K. Lee, MD Host: Lee Freedman, MD Dr. John Y.K. Lee, assistant professor of neurosurgery and medical director of the Gamma Knife Center within the University of Pennsylvania Health System, details the neurosurgical utility of the...Show More
The Paradigm Shift In Our Approach to Medications

0:00 | Oct 9th, 2007

Guest: Garret FitzGerald, MD Host: Lee Freedman, MD Dr. FitzGerald outlines how the collaborative work of multiple disciplines is leading to a brave new world when it comes to the development of medications and how, in the near future, the con...Show More
Personalized Medicine

0:00 | Oct 9th, 2007

Guest: Garret FitzGerald, MD Host: Lee Freedman, MD Dr. FitzGerald discusses how advances in molecular biology and our understanding of the human genome will lead to a paradigm shift in how we approach the development and prescibing of medicat...Show More