JNNP podcast

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JNNP's ambition is to publish the most ground-breaking and cutting-edge research from around the world. Encompassing the entire genre of neurological sciences, our focus is on the common disorders (stroke, multiple sclerosis, Parkinson's disease, epi...Show More
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The real patient value

12:44 | Apr 18th

The JNNP recently launched the patient editorial board in an effort to drive more meaningful patient outcomes. One of our newly appointment board members, Sharon Roman (Vancouver Canada) discusses why she believes the patient perspective leads to bet...Show More
Medical conferences - what do we get out of them?

09:30 | Apr 4th

A special edition podcast - based on an essay discussing the value of medical conferences and whether it is time to consider what is gained from these events, and for whom. Emeritus Professor Michael Swash (The Royal London Hospital and Barts and the...Show More
Oral immunotherapies in MS a comparison of efficacy.

12:13 | Mar 25th

Associate Professor Tomas Kalincik (University of Melbourne, Australia) discusses oral immunotherapies, and what we know about the effects of these treatments on patient relapse and disability. Read the full paper here: https://jnnp.bmj.com/content/e...Show More
Therapeutic trial design in frontotemporal dementias

13:06 | Mar 20th

Editor’s Choice: Associate Professor Dr Mario Masellis (University of Toronto) and Assistant Professor Philippe Desmarais (University of Montreal) discuss the complexities of designing trials in frontotemporal dementia (FTD) and how precision medicin...Show More
Do genes affect age of onset in ALS?

09:50 | Mar 11th

Professor Ammar Al-Chalabi (King’s College London, London, UK) joins Elizabeth Highton (podcast editor) to discuss motor neurone disease, also known as amyotrophic lateral sclerosis or ALS, a rapidly progressive illness resulting from the degeneratio...Show More
The lifetime risk of common neurological disorders in the elderly population

06:17 | Feb 18th

We have a good understanding of our risk of developing cancer or heart disease – but what do we know about the risk of developing a common neurological disorder in later-life? Dr. Silvan Licher (Department of Epidemiology, University Medical Center R...Show More
PMA and PLS: are they really restricted phenotypes?

08:57 | Feb 4th

Dr. Michael van Es (University Medical Center Utrecht, Netherlands) examines whether cognitive and behavioural changes can be seen across the motor neurone disease spectrum, and how this helps inform our understanding of these as multidimensional dis...Show More
Statins and the risk of recurrent intracerebral haemorrhage (ICH) – what does the evidence say?

12:02 | Jan 21st

Do statins increase the risk of intracerebral haemorrhage (ICH) in patients with a previous stroke? Professor David Werring (Stroke Research Centre, UCL Institute Of Neurology, Queen Square, London, UK) joins Elizabeth Highton (JNNP podcast editor) f...Show More
Functional impairment and improvement

28:56 | Dec 10th, 2018

Elizabeth Highton (podcast editor) hosts the final JNNP podcast for 2018, an episode on functional improvement after stroke (Dr. Aravind Ganesh, University of Oxford, UK- https://jnnp.bmj.com/content/89/12/1301) and cognitive impairment in functional...Show More
Can computational models help us understand complex movement disorders?

11:52 | Oct 29th, 2018

Professor Mark Humphries (University of Nottingham, UK) discusses how computational modelling could be a crucial tool in untangling the complexities of diseases like Parkinson’s disease. Can this type of modelling help us understand causes, and event...Show More
Idiopathic intracranial hypertension: guidelines for diagnosis and management

14:55 | Oct 8th, 2018

In collaboration with many different specialists, professions and patient representatives, Mollan et al (2018) have developed the first ever guidelines for the investigation and management of idiopathic intracranial hypertension (IIH). Senior author...Show More
Nusinersen for SMA

10:20 | Aug 29th, 2018

Elizabeth Highton (JNNP Podcast Editor) speaks with Dr. Michelle Farrar (University of New South Wales) discussing nusinersen, the first disease-modifying therapy for spinal muscular atrophy type 1 (SMA). https://jnnp.bmj.com/content/89/9/937
Expanding clinical spectrums in both Kennedy's disease and poststroke syndromes

28:47 | Aug 6th, 2018

Dr. Carlo Rinaldi (University of Oxford) discusses how the traditional view of Kennedy’s disease is evolving, to extend beyond pure motor symptoms. What non-motor features may be present in Kennedy's, and crucially how do they impact on patient's car...Show More
The use of cannabis in epilepsy, and surgery for tremor

23:28 | Jul 2nd, 2018

Around 20-30% of patients with epilepsy can demonstrate resistance to commonly used medications. Cannabidiol (CBD) is a compound found in cannabis, which can be used for the treatment of epilepsy, shown to actively modulate seizure activity. Dr Emil...Show More
Epilepsy an evidence update

20:52 | May 31st, 2018

Is the mesial temporal lobe the seat of psychosis in epilepsy? James Allebone (University of Melbourne, Australia) discusses what neuroimaging can tell us about psychosis in epilepsy. Read the paper here: http://jnnp.bmj.com/content/89/6/611. Pati...Show More
Evolution or revolution? Should we re-think clinical practice?

18:31 | Apr 30th, 2018

Do old habits of screening for potassium channel antibodies stand up to scrutiny? Should clinical neurologists focus on screening for LGI1 and CASPR2 antibodies? Professor Sarosh Irani (John Radcliffe Hospital, Oxford) discusses antibody testing, and...Show More
The Use of Frankincense Extract In MS

16:55 | Apr 4th, 2018

Patients with multiple sclerosis (MS) often show interest in complementary and alternative medicines, particularly when on long-term anti-inflammatory treatments. Is frankincense a safe and tolerable treatment? Dr Klarissa Stürner (Christian-Albrecht...Show More
A new questionnaire to measure quality of life in inflammatory neuropathies

08:08 | Mar 7th, 2018

Quality of life (QoL) is one of the most important outcomes for chronic diseases, although it remains remarkably difficult to quantify. Dr. Thomas Draak (Maastricht University, The Netherlands) discusses his new questionnaire, and how it aims to cap...Show More
Marriage and a reduced risk of dementia

14:48 | Feb 28th, 2018

Recent research has indicated that being married is associated with a reduced risk of dementia. What is it about marriage? Dr Andrew Sommerlad (University College London) discusses this question and more. Read the full paper here: http://jnnp.bmj.com...Show More
Anti-inflammatory approaches to stroke prevention; monitoring disease progression in ALS

31:00 | Feb 8th, 2018

Atherosclerosis is a major contributor to increased risk of stroke. Our patient’s choice, Professor Peter Kelly (University College Dublin, Dublin, Ireland) discusses the evidence base implicating inflammation as a key process in the pathogenesis of ...Show More
Nodes and paranodes; alternative treatments in MS

18:29 | Jan 26th, 2018

People with multiple sclerosis (MS) use complementary and alternative treatments (CAM), but what does the evidence say? Patient’s Choice, Professor Bruce Taylor (University of Tasmania) discusses the modern evidence for CAM use. Read the paper here: ...Show More
Pathophysiology of functional neurological disorder

11:15 | Dec 13th, 2017

Despite the prevalence of the disease, neurologists and psychiatrists can be wary of treating patients with functional neurological disorder (FND). Assistant Professor David Perez (Massachusetts General Hospital, USA) discusses how FND sits between n...Show More
Is methamphetamine use linked to stroke in young adults?

09:54 | Nov 28th, 2017

Is methamphetamine use linked to strokes in young adults? Important clinical implications discussed by Dr. Julia Lappin (University of New South Wales) in this month’s JNNP podcast. http://jnnp.bmj.com/content/88/12/1079
Cerebral Amyloid Angiopathy: New Insights For Clinical Practice

18:35 | Nov 8th, 2017

Cerebral amyloid angiopathy (CAA) has been gaining attention over the past few years, thanks to increased research in the field. Professor David Werring (UCL Institute of Neurology, Queens Square, London) discusses the recent advances in biomarkers a...Show More
Cortical Influences in ALS

20:58 | Oct 31st, 2017

Professor Emeritus Andrew Eisen (University of British Columbia, Canada) discusses the theory of corticofugal primary in amyotrophic lateral sclerosis. ALS can be viewed as a primarily human disorder mediated by corticomotorneuronal pathways, origina...Show More
Intravenous immunoglobulin in CIDP

11:40 | Oct 23rd, 2017

Can IViG be used as a longer term maintenance therapy for CIDP patients? JNNP Associate Editor, Professor Satoshi Kuwabara (Chiba University Hospital, Japan) joins us for this podcast, discussing recent trial results and their implications for patien...Show More
Complex inherited neuropathies: a new approach to diagnosis?

18:22 | Oct 18th, 2017

Professor Mary Reilly (Institute of Neurology, Queens Square, London) discusses how complex inherited neuropathies can be a daunting diagnosis for clinicians. However, through exciting advances in next generation sequencing and knowledge of distinct ...Show More
Cerebellum and neurodegeneration; autoantibodies and psychological development in children

15:37 | Sep 4th, 2017

The September 2017's JNNP podcast is a double episode. The first conversation is with Professor Michael Hornberger from the Norwich Medical School, University of East Anglia, UK. The cerebellum is often overlooked when looking at neurodegenerative d...Show More
Time Matters - part 2: how the real costs of multiple sclerosis are being concealed

11:21 | Aug 7th, 2017

“Take a comprehensive economic approach to evaluating treatment cost-effectiveness in MS”. Jacqueline Palace (Consultant Neurologist, Nuffield Department of Clinical Neurosciences, University of Oxford) and Ruth Geraldes (Neurologist, Department of C...Show More
Survival and cause of death in Multiple Sclerosis

13:23 | Jul 19th, 2017

There has been an increase in life expectancies for the general population over the last few decades. A similar trend has also been identified in patients with Multiple Sclerosis (MS). To investigate this trend further, Dr Lunde and colleagues, from...Show More
Time Matters - part 1: delay is “expensive” in all aspects of multiple sclerosis

11:25 | Jul 10th, 2017

Professor Emeritus Alastair Compston (University of Cambridge) discusses with JNNP’s Publisher Janet O'Flaherty the issues raised by the discussion “Brain health matters in multiple sclerosis” (MS), which was part of the international roundtable “Tim...Show More
Seven tesla MRI In Neurodegenerative Dementias

11:25 | Jun 16th, 2017

MRI is an important clinical tool to study dementia symptoms in vivo. However, certain pathologies (microbleeds, plaques, tangles) can evade current imaging techniques. Seven tesla (7T) MRI provides a potentially exciting new opportunity to visualise...Show More
Conversational Laughter In Dementia

13:52 | May 5th, 2017

Laughter serves a fundamental social purpose, the appropriate use of which requires recognition of social norms. So what happens when these interpersonal abilities are affected, such as in the frontotemporal dementias? Does use of laughter change too...Show More
Narrative and Neurology: The Andrew Lees Experiment

32:54 | Apr 6th, 2017

Professor Andrew Lees discusses his book "Mentored by a Madman: The William Burroughs Experiment" with Dr Sean O’Sullivan and Elizabeth Highton. Andrew speaks to the importance of looking beyond one’s area of expertise for mentorship, the relationshi...Show More
April 2017: deconstructing dilemmas in Amyotrophic Lateral Sclerosis and Guillain-Barré Syndrome

18:14 | Mar 27th, 2017

Both patient and editor's choices are discussed in this monthly episode of the JNNP podcast. The clinical care of patients with Guillain-Barré syndrome (GBS) can often be complex; a disease with a highly variable clinical course. Professor Bart Ja...Show More
Zika virus and Guillain-Barré Syndrome: what do we know?

15:01 | Mar 13th, 2017

There is concern that, despite being a rare complication of the Zika virus, we could see a steady rise in the number of cases of Guillain-Barré Syndrome (GBS). In preparation for this, it is important that clinicians are able to appropriately identif...Show More
Immunomodulatory therapy in advanced multiple sclerosis

14:05 | Feb 13th, 2017

Could currently available immunomodulatory therapies modify disability trajectories in patients with moderately advanced and advanced multiple sclerosis (MS)? Tomas Kalincik, Department of Medicine, University of Melbourne, Australia, discusses the...Show More
The relationship between orthostatic hypotension and cognitive impairment in α-synucleinopathies

11:06 | Nov 30th, 2016

Dr Mario Masellis and Dr. Sean Udow from the Sunnybrook Health Sciences Centre, University of Toronto, Canada, look at the potential association between orthostatic hypotension and cognitive impairment in α-synucleinopathies such as Parkinson’s disea...Show More
A clinical tool for predicting survival in motor neurone disease

08:31 | Nov 30th, 2016

Elizabeth Highton spoke to Professor Ammar Al-Chalabi from King’s College London about the development of a simple and clinically useful graphical model of predicting survival for motor neurone disease (MND) patients. Read the article here: http:/...Show More
Latitude and disease severity in Multiple Sclerosis

11:20 | Nov 15th, 2016

Elizabeth Highton and Prof. Bruce Taylor discuss higher latitudes and its association with earlier age of onset of Multiple Sclerosis (MS). The international study, published by the JNNP, links latitude to the age at which symptoms of MS first sta...Show More
Do your kids play rugby? Risks for rugby union players from repeated concussions

17:53 | Nov 7th, 2016

Associate Editor of JNNP Alan Carson interviews Tom McMillan, Professor at the Institute for Health & Wellbeing, University of Glasgow, UK, about the paper "Long Term Health Outcomes after Exposure to Repeated Concussion in Elite Level Rugby Union Pl...Show More
Genetics and the clinical course of multiple sclerosis

10:32 | Oct 18th, 2016

Professor Bruce Taylor and Elizabeth Highton discuss how certain genetic risk variants may predict the clinical course and progression of Multiple Sclerosis. This podcast relates to the Patient Choice paper published in the JNNP November 2016 issu...Show More
Is it time to focus on the common pathways linking neurodegenerative diseases?

13:44 | Oct 13th, 2016

Dr. Rebekah Ahmed talks about her recent JNNP review: Neuronal network disintegration and the common pathways linking neurodegenerative diseases. Dr. Ahmed and colleagues critically evaluate a new approach to neurodegenerative disease, a focus on ...Show More
October 2016 Edition: long-term outcomes after stroke; hereditary and inflammatory neuropathies

18:39 | Sep 22nd, 2016

In this JNNP podcast, Elizabeth Highton speaks with Dr. Siobhan Crichton and Dr. Benjamin Bray about their study looking at patient outcomes up to 15 years after stroke. Read their full paper here: http://jnnp.bmj.com/content/early/2016/07/22/jnnp-...Show More
Selective vulnerability in clinical variants of Alzheimer's Disease

16:02 | Aug 30th, 2016

Elizabeth Highton spoke with Professor Henrik Zetterberg from Sahlgrenska University in Sweden. They discuss his recent JNNP review looking at clinical variants of Alzheimer's Disease and whether selective vulnerability in the nervous system may help...Show More
Smoking: a negative prognostic for survival in motor neurone disease patients

10:22 | Aug 19th, 2016

Elizabeth Highton is joined by Prof. Adriano Chio to talk about his study: Influence of cigarette smoking on ALS outcome: a population-based study. His large population-based cohort study of patients with amyotrophic lateral sclerosis (ALS), comm...Show More
Review: Amyotrophic Lateral Sclerosis and Motor Neuron Syndromes in Asia

14:52 | Jul 27th, 2016

In this podcast, Dr Nortina Shahrizaila, a neurologist from the University of Malaya, talks about her review regarding Amyotrophic lateral sclerosis and motor neuron syndromes in Asia. She discusses with Elizabeth Highton what is known of ALS in Asia...Show More
Automated brain volumetrics in multiple sclerosis, plus migraine and psychiatric co-morbidities

21:36 | Jun 30th, 2016

In this July podcasts, Associate Professor Michael Barnett explains the details of his short report comparing Structural Image Evaluation using Normalisation of Atrophy-Cross Sectional (SIENAX) to Neuroquant and MSmetrix for assessment of cross-secti...Show More
Coffee consumption and multiple sclerosis

11:05 | Jun 7th, 2016

Can coffee impact on the health of neurons? And what are the effects of its consumption on the risk of developing multiple sclerosis? These are some of the questions Dr Ellen Mowry answers in this podcast. She is an Associate Professor of Neurolog...Show More
June Edition: Parkinson’s disease and the rate of ALS progression

22:00 | May 24th, 2016

In this podcast, Elizabeth Highton investigates the details of two studies selected for the June 2016 edition of JNNP. Professor Steve Vucic, from the Department of Neurology at Westmead Hospital, Sydney, talks about the details of his study, whic...Show More
Sudden Unexpected Death in Epilepsy: basic mechanisms and implications for prevention

09:53 | Apr 8th, 2016

In this podcast, Dr Brian J Dlouhy explains the mechanisms behind sudden unexpected death in epilepsy (SUDEP), one of the most common cause of death in patients with intractable epilepsy. “Sudden unexpected death in epilepsy: basic mechanisms and cl...Show More
Re-evaluating the treatment of acute optic neuritis

19:17 | Feb 10th, 2016

In this podcast, Professor Elliot Frohman discusses the treatment of acute optic neuritis and its connection with multiple sclerosis. Elliot Frohman is Professor of Neurology and Neurotherapeutics and Ophthalmology and Director of the Multiple Scler...Show More
BNPA 2015: Spatial Neglect

05:27 | Jun 8th, 2015

Kieran O'Driscoll, Neuropsychiatrist, Manchester, speaks to Giuseppe Vallar, Professor of Psychobiology and Physiological Psychology, University of Milano-Bicocca, about spatial neglect. This podcast was recorded at the 2015 BNPA AGM.
BNPA 2015: New theories of memory systems and networks

10:27 | Jun 8th, 2015

Chris Butler speaks to Adam Zeman about new theories of memory systems and networks. This podcast was recorded at the 2015 BNPA AGM.
BNPA 2015: Phantom phenomena

05:22 | Feb 24th, 2015

David Linden, neuropsychiatrist, Cardiff, Wales, talks to Peter Brugger, Department of Neurology, University Hospital Zurich, about phantom phenomena. This podcast was recorded at the BNPA 2015 AGM.
Clinical neurology: why this still matters in the 21st century

11:32 | Jan 27th, 2015

David Nicholl argues that even with the tremendous advances in diagnostic neuroimaging that the clinical skills involved in clinical neurology remain key. In a recent JNNP review he writes that recent audits suggest that large numbers of patients are...Show More
Imaging outcomes for trials of remyelination in multiple sclerosis

11:56 | Dec 11th, 2014

Trials of potential neuroreparative agents are becoming more important in the spectrum of multiple sclerosis research. Appropriate imaging outcomes are required that are feasible from a time and practicality point of view, as well as being sensitive ...Show More
BNPA 2014: Oxytocin and social cognition

06:57 | Dec 2nd, 2014

Individual differences in our capacity to read other people’s emotions and to remember faces we have seen before are highly variable in the general population. Some people are super-recognizers; others have difficulty remembering their own family mem...Show More
BNPA 2014: Schizophrenia and cognition

08:06 | Dec 2nd, 2014

Cognitive impairment is generally considered an important facet of the schizophrenia syndrome but how fundamental is it? In this podcast Alan Carson discusses the question with Eileen Joyce, Consultant Neuropsychiatrist at the National Hospital f...Show More
Advances in epilepsy surgery

17:51 | Nov 27th, 2014

Exciting recent and forthcoming advances will impact on the surgical management of epilepsy in the near future. Mark Nowell and John Duncan, both Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, have conducted a review...Show More
Brain atrophy and disability progression in multiple sclerosis patients

11:24 | Oct 13th, 2014

Dr Robert Zivadinov, Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, discusses his paper which aimed to identify MRI biomarkers associated with long-term disability progression in patients wi...Show More
BNPA 2014: Joint hypermobilty and autonomic hyperactivity

05:13 | Sep 17th, 2014

Chis Butler, MRC Clinician Scientist and Honorary Consultant Neurologist at the University of Oxford, talks to Jessica Eccles, MRC Clinical Research Training Fellow, Brighton and Sussex Medical School, about her work into joint hypermobilty and auton...Show More
BNPA 2014: Post-Ictal psychosis

05:10 | Sep 17th, 2014

Hugh Rickards, consultant in Neuropsychiatry and honorary reader in Neuropsychiatry at Birmingham University, talks to Georgy Pius, ST6 Trainee, North West Deanery, about his case-control study examining post-ictal psychosis. Read the abstract: ht...Show More
BNPA 2014: TREM2 variants and risk of dementia

04:48 | Sep 17th, 2014

Chris Butler, MRC Clinician Scientist and Honorary Consultant Neurologist at the University of Oxford, talks to Catherine Slattery, Clinical Research Associate, Institute of Neurology, about her work looking at TREM2 and associated risk of dementia. ...Show More
Neurosurgical procedures for psychiatric illness

17:53 | Sep 17th, 2014

This month, how to safely and ethically carry out stereotactic surgery for psychiatric illness. Bart Nuttin, Department of Neurosurgery, University of Leuven, has put together pragmatic guidelines, with the input of international psychiatric and n...Show More
Can stress trigger Parkinson's? And new criteria for frontotemporal dementia syndromes.

36:54 | Aug 5th, 2014

Does emotional stress trigger Parkinson's disease? Andrew Lees, Reta Lila Weston Institute of Neurological Studies, talks us through the evidence so far.And Glenda Halliday, Neuroscience Research Australia, and colleagues, have examined the clinical ...Show More
HIV and multiple sclerosis: beginning to unravel a mystery

13:27 | Jul 2nd, 2014

Julian Gold, professor in the department of neuroscience and trauma, Queen Mary, University of London, and senior staff specialist, Albion Centre, Prince of Wales Hospital, Sydney, discusses his paper which investigates whether or not HIV protects ag...Show More
BNPA 2014: Neuropsychiatry of social knowledge and moral motivation

11:08 | Jun 24th, 2014

JNNP editor Alan Carson asks Roland Zahn, senior clinical lecturer, King's College London, about the neuroanatomy of moral behaviour, particularly his work into the neural mechanism of moral emotion in depression.This podcast was recorded at the 2014...Show More
DBS in essential tremor, and genetic counselling for ALS

22:34 | May 22nd, 2014

This month, genetic counselling for amyotrophic lateral sclerosis (ALS). Adriano Chiò, Turin ALS Expert Center, ‘Rita Levi Montalcini’ University of Turin, tells us what it can and can't do, who should have it, and how to go about it.And deep brain s...Show More
Mortality and morbidity 15 years after hospital admission with mild head injury

14:18 | Apr 30th, 2014

Head injury is very common, and we know those admitted to hospital with a severe head injury have a high mortality rate in the proceeding year. However less is known about later mortality, and even less about late survival after mild head injury, whi...Show More
Informed decision making in MS, and the striatum in neurodegeneration

29:38 | Apr 4th, 2014

What's the role of the striatum, in changes in cognition and behaviour in neurodegeneration? Michael Hornberger, University of Cambridge, explains why it may be more pivotal than we currently think.And how best to support patients just diagnosed with...Show More
BNPA special: Autoimmune encephalitis

10:59 | Mar 14th, 2014

Angela Vincent, emeritus professor of neuroimmunology at the University of Oxford, gives Adam Zeman, professor of cognitive and behavioural neurology, University of Exeter, an overview of autoimmune disorders of the central nervous system.This podca...Show More
BNPA special: The prospects of a vaccine for Alzheimer's disease

10:08 | Mar 13th, 2014

Adam Zeman, professor of cognitive and behavioural neurology, University of Exeter, asks James Nicoll, professor of neuropathology, University of Southampton, about the progress being made in preventative treatments for Alzheimer's.For more on early ...Show More
An unusual variant of Guillain–Barré syndrome, and dopamine dysregulation syndrome

25:57 | Mar 4th, 2014

This month, an unusual variant of Guillain Barre syndrome - the pharyngeal cervical brachial variant. Benjamin Wakeley, a consultant neurologist at the Gloucester Hospitals NHS Foundation trust talks through what clinicians need to know.Also, a look ...Show More
BNPA special: Impulse control disorder in Parkinson's

08:41 | Mar 3rd, 2014

Kieran O'Driscoll, consultant neuropsychiatrist in Liverpool, talks to David Okai, a consultant in psychological medicine in Oxford and researcher at King's College London, discusses assessing and managing impulse control disorder in Parkinson's.This...Show More
Diagnosing and treating functional symptoms

27:59 | Jan 10th, 2014

February's JNNP is a neuropsychiatry special issue, with papers on a broad range of disorders which lie between neurology and psychiatry. Associate editor Alan Carson discusses the contents, and the thinking behind the edition.To accompany the issue,...Show More
Solving the case, making the diagnosis: Neurology and detective writing

19:44 | Jan 9th, 2014

When searching for clues to reach a diagnosis, neurologists often empathise with the detective who is trying to solve a case, write Peter Kempster and Andrew Lees in JNNP sister journal Practical Neurology bit.ly/1dqReQq. In this podcast, journal ...Show More
Radiation for brain metastases, and the genetics of ischaemic stroke

27:14 | Nov 26th, 2013

This month, whole brain radiation vs radiosurgery for cerebral metastases. Does the former cause significantly more cognitive defects, and are any blanket, mopping up effects worth it? Clark Chen, vice chairman of neurosurgery, University of Califor...Show More
Education special: Headache

19:44 | Nov 26th, 2013

Callum Duncan, neurologist at Aberdeen Royal Infirmary, convenes a round table of experts to discuss advances in headache, particularly the pathophysiological understanding of cluster headache, managing cluster headache and migraine, and new onset ch...Show More
Aggressive MS, and disappointment following deep brain stimulation for Parkinson's

21:05 | Oct 25th, 2013

This month, getting a handle on aggressive multiple sclerosis. Suresh Menon and Helen Tremlett, both from the Department of Medicine, University of British Columbia, talk us through their recent step towards a definition of the disease.And Parkinson'...Show More
Vitamin D, sunlight, and MS

10:40 | Oct 15th, 2013

October's JNNP takes another step towards demystifying the relationship between sunlight, vitamin D, and MS, featuring a paper which reveals sun exposure may have direct effects on neurodegeneration independently of the vitamin.Murali Ramanathan, co-...Show More
Education special: Neurogenetics update

09:39 | Oct 15th, 2013

Ralph Gregory, secretary for the Association of British Neurologists and consultant neurologist in Dorset, gets an update on neurogenetics research and implications for practice from Nick Wood, professor of clinical neurogenetics, Institute of Neurol...Show More
Diagnosing and treating neuromyelitis optica

21:29 | Aug 19th, 2013

Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder with predilection for the optic nerves and spinal cord. Many recent advances, in particular, the discovery of NMO-IgG, an NMO-specific autoantibody, have furthered our understanding of...Show More
Diagnosing the dementias

27:58 | Jul 23rd, 2013

This month, we get an update on the latest in clinically diagnosing the dementias, with a roundtable of experts convened by the Association of British Neurologists. Taking part are John Greene, Southern General Hospital, Glasgow, Chris Butler, Depart...Show More
Anti-GQ1b antibody syndrome, and ALS and language deficits

27:39 | Jul 5th, 2013

We know that ALS is associated with executive dysfunction, but what about language deficits? Steven Wing, specialist neurology registrar at Addenbrooke’s Hospital, Cambridge, talks to Laura Goldstein, professor of Clinical Neuropsychology at the Inst...Show More
Striatal cell transplants for Huntington’s disease: where are we now?

20:28 | Jul 5th, 2013

In Huntington’s disease the striatum takes a big hit early. This has prompted trials of foetal stratal transplantation, in the hope that this may provide some relief to patients.Stevan Wing, specialist neurology registrar at Addenbrooke’s Hospital, a...Show More
Education special: MS update

14:40 | Jun 11th, 2013

Ralph Gregory, secretary for the Association of British Neurologists and consultant neurologist in Dorset, gets an update on multiple sclerosis research and implications for practice from Neil Robertson, professor of neurology, Cardiff University.The...Show More
Education special: Peripheral nerve disease update

20:02 | Jun 11th, 2013

Ralph Gregory, secretary for the Association of British Neurologists and consultant neurologist in Dorset, gets an update on peripheral nerve disease research and practice from James Overell, consultant neurologist, Institute of Neurological Sciences...Show More
Stem cells in neurology, and enlarged perivascular spaces and intracerebral haemorrhage

33:57 | Jun 11th, 2013

Where are we with stem cell treatments for stroke and Parkinson’s disease? At the Association of British Neurologists’ recent annual meeting in Glasgow, Neil Scolding, director of the Bristol Institute of Clinical Neurosciences, spoke to Keith Muir, ...Show More
Parkinson’s disease subtypes: lost in translation?

12:51 | May 1st, 2013

This month Connie Marras, assistant professor of neurology, University of Toronto, talks us through her review of Parkinson’s disease subtypes.What definitions do we have so far, what could they tell us about the condition, and how can we get them in...Show More
The latest on stroke

33:49 | May 1st, 2013

In this special edition of the podcast, JNNP associate editor Nick Ward looks into some of the latest research into stroke.Tracking cognitive function in those recovering from stroke in routine. Owen White, associate professor, Department of Neurolog...Show More
Dopamine agonist withdrawal syndrome

10:44 | May 1st, 2013

The problem of those with Parkinson’s disease becoming addicted to dopamine replacement therapy is well know, but it’s also now emerging that some patients have trouble coming of dopamine agonists.Margarita Pondal, from the Movement Disorders Centre,...Show More
BNPA 2013: The impact of epilepsy on cognitive function

11:13 | Feb 18th, 2013

Cognitive impairment in those with epilepsy is common. Adam Zeman, professor of cognitive and behavioural neurology, University of Exeter, ask Christoph Helmstaedter, associate professor for clinical neuropsychology, the University Clinic of Epilepto...Show More
BNPA 2013: Psychedelic drugs, magical thinking and psychosis

06:39 | Feb 18th, 2013

Robin Carhart-Harris, post-doctoral researcher, Division of Brain Sciences, Imperial College London, explains his hypothesis on the shared neurobiology of psychosis, psychedelic states and spontaneous spiritual experiences to Peter Halligan, professo...Show More
BNPA 2013: Decoding consciousness

03:48 | Feb 18th, 2013

What relevance does consciousness have for our understanding of mental conditions? Geraint Rees, deputy head of the UCL Faculty of Brain Sciences, tells Peter Halligan, professor in the School of Psychology, Cardiff University, about his work in the ...Show More
BNPA 2013: Epilepsy, depression and anxiety disorders

11:55 | Feb 18th, 2013

There is a complex relationship between epilepsy, depression, and anxiety disorders. Adam Zeman, professor of cognitive and behavioural neurology, University of Exeter, discusses the associations and what they mean for practice with Andres Kanner, di...Show More
BNPA 2013: Brain networks in human epilepsy

07:15 | Feb 18th, 2013

How epileptic seizures start is unclear. Mark Richardson, professor of epilepsy, Institute of Psychiatry, is working on elucidating this question using computational models. He talks Markus Reuber, professor of clinical neurology, University of Sheff...Show More
BNPA 2013: Cellular mechanisms of epilepsy

07:46 | Feb 18th, 2013

Markus Reuber, professor of clinical neurology, University of Sheffield, discusses the different cellular mechanisms which allow seizures in epilepsy to happen, and how this understanding could lead to disease modification with John Jefferys, profess...Show More
BNPA 2013: Autoimmunity and neuropsychiatry

10:56 | Feb 18th, 2013

Tim Nicholson, academic clinical lecturer, Institute of Psychiatry, gives Hugh Rickards, consultant in neuropsychiatry, University of Birmingham, an update on autoimmune mechanisms and encephalitis. Dr Nicholson covers where we are with understanding...Show More
BNPA 2013: Deep brain stimulation for mental illness

08:50 | Feb 18th, 2013

Eileen Joyce, professor in neuropsychiatry at the Institute of Neurology, gives Hugh Rickards, consultant in neuropsychiatry, University of Birmingham, an update on the use of deep brain stimulation to treat mental disorders, particularly OCD.This po...Show More
BNPA 2013: The neural correlates of Freudian “repression” in conversion disorder

07:05 | Feb 18th, 2013

Selma Aybek, clinician researcher, Service of Neurology, University of Lausanne, has been examining the process which allows psychological stressors to become physical symptoms in conversion disorder. Chris Butler, academic clinical lecturer in neuro...Show More
BNPA 2013: Effects of early childhood posterior fossa tumours on IQ

07:35 | Feb 18th, 2013

Cliodhna Carroll, along with colleagues at the University of Cambridge, has shown that children who’ve had a posterior fossa tumour have a lower IQ than matched controls. She talks Chris Butler, academic clinical lecturer in neurology, University of ...Show More
BNPA 2013: Epilepsy and affective disorders, the role of the subgenual prefrontal cortex

07:34 | Feb 18th, 2013

Chris Butler, academic clinical lecturer in neurology, University of Oxford, talks to Rebecca Cleary, research assistant, Wellcome Trust Centre for Neuro-imaging, UCL, about her research investigating whether the neural substrate in those with depres...Show More
BNPA 2013: Stress and war, and the limits of neuropsychiatry

09:40 | Feb 18th, 2013

Neil Greenberg, academic psychiatrist, Kings College London, who’s served in the armed forces for more than 20 years, argued in his JNNP-sponsored keynote at BNPA that we understand many of the issues in military mental health, and that the neuropsyc...Show More
BNPA 2013: Childhood stress and risk for later mental disorder

10:19 | Feb 18th, 2013

David Skuse, professor in the Behavioural Sciences Unit, Institute of Child Health, talks to Jeremy Hall, professor of psychiatry and neuroscience at the University of Cardiff, about his work investigating the link between childhood stress and border...Show More
BNPA 2013: Inflammation and mental illness

07:40 | Feb 18th, 2013

Alan Carson, JNNP associate editor, talks to Neil Harrison, consultant neuropsychiatrist and head of psychoneuroimmunology, Brighton and Sussex Medical School, about what we currently know about inflammation in mental disorders. Dr Harrison also disc...Show More
BNPA 2013: Posttraumatic stress disorder and the brain

09:41 | Feb 18th, 2013

David Skuse, professor in the Behavioural Sciences Unit, Institute of Child Health, asks Chris Brewin, professor of clinical psychology, UCL Faculty of Brain Sciences, about the different forms of PTSD experience, the cognitive processes involved, an...Show More
BNPA 2013: Equipped to survive, how comprehensive response to threat enables optimal behaviour

07:47 | Feb 18th, 2013

The human response to threat requires comprehensive change in the network properties of the brain, with the whole organ affected. Alan Carson, JNNP associate editor, asks Guillén Fernández, director of the Donders Center for Neuroscience, Radboud Uni...Show More
Discovering Emery-Dreifuss muscular dystrophy, and flavour identification in FTLD

22:13 | Feb 15th, 2013

In the last JNNP podcast of 2012, we look at what jelly beans and the Andalucian mountains have done for neurology and psychiatry.Alan Emery, emeritus professor, Green Temple College, University of Oxford, describes studying the family that led him t...Show More
The future of epilepsy research, assessing hemianopia, measuring sensory nerve action potentials

31:46 | Feb 15th, 2013

This month, Mark Richardson, professor of epilepsy, Kings College London, relates his vision for the future of epilepsy research (1.07).Alexander Leff, consultant neurologist, Institute of Cognitive Neuroscience, University College London, discusses ...Show More
The Scheltens scale, disability after head injury, and cannabis for multiple sclerosis

23:04 | Feb 15th, 2013

This month, we explore the latest research on treating multiple sclerosis with cannabis extract. Editor Matthew Kiernan speaks to John Zajicek, professor of Clinical Neuroscience, Peninsula College of Medicine and Dentistry, UK. (0.54)Received wisdom...Show More
Early days of the Queen Square brain bank; rating dopaminergic replacement therapy response

31:43 | Feb 15th, 2013

The Queen Square brain bank was set up by Andrew Lees, and whilst there he co-authored two of JNNP’s most highly cited papers – one on the importance of Lewy bodies in Parkinson’s, and the other on the accuracy of clinical diagnosis of the disease. N...Show More
Oliver Sacks’s functional paralysis; progressive multifocal leukoencephalopathy

20:49 | Feb 15th, 2013

In 1974 Oliver Sacks was hiking through a remote part of Norway when he suffered a nasty injury to one leg. Although he managed to get to help and was successfully operated on, he struggled to relearn to walk and felt alienated from the limb. Jon Sto...Show More
Recovery after stroke; malingering after concussion

27:29 | Feb 15th, 2013

Derick Wade (professor and consultant in neurological rehabilitation at the Oxford Centre for Enablement) and Nick Ward (JNNP associate editor and reader in clinical neurology at UCL) discuss the past, present and future of measuring and predicting r...Show More
The future of glioblastoma therapy

13:47 | Feb 15th, 2013

Despite current standard care for glioblastoma being aggressive, mean survival is around 14 months. Clark Chen (director of Clinical Neuro-oncology, Beth Israel Deaconess Medical Center, Boston) argues we need a better understanding of the therapeuti...Show More
Neurological symptoms from autoimmune syndromes; movement disorders and OCD; counting strokes

34:32 | Feb 15th, 2013

This month, editor Matthew Kiernan discusses new guidelines for recognising central nervous system neuronal surface antibody associated symptoms with Angela Vincent (emeritus professor of neuroimmunology at Oxford University).Danielle Cath (psychiatr...Show More
Idiopathic intracranial hypertension; discovering the neurological effects of critical illness

23:19 | Feb 15th, 2013

This month Beau Bruce (assistant professor of ophthalmology and neurology, Emory University School of Medicine, Atlanta) discusses what we do and don’t know about idiopathic intracranial hypertension, and offers some clinical advice on the syndrome f...Show More
Diagnostic criteria for CBS; tractography in ALS fifty years ago; better tests for bvFTD

31:13 | Feb 15th, 2013

In April’s podcast, we put a spotlight on amyotrophic lateral sclerosis and frontotemporal dementia.Maxime Bertoux, a neuropsychologist at Paris-Sorbonne University, discusses the problem of misdiagnosis of the behavioural variant of FTD, and how he’...Show More
Surrogate outcomes; CAA and IH; Angela Vincent looks back

26:02 | Feb 15th, 2013

This issue we look at short-term outcomes used to assess multiple sclerosis treatments, and their power to predict long-term disability, with Douglas Goodin (professor of clinical neurology, University of California, San Francisco).We return to the a...Show More
Cerebral amyloid angiopathy; lifestyle and mortality after stroke; motor output patterns

22:33 | Feb 15th, 2013

This month, cerebral amyloid angiopathy. David Werring (Stroke Research Group, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery) discusses the importance of detecting it, especially as he feels it is under-recognise...Show More
The early days of chronic fatigue syndrome research; Clues to functional weakness mechanism

29:38 | Feb 15th, 2013

In this first podcast of 2012 editor Matthew Kiernan talks about JNNP’s new impact commentaries - a series which will explore influential papers from the journal. A paper by Simon Wessely (King’s College London) comparing postviral fatigue with that ...Show More
Diagnosing delirium

12:55 | Feb 15th, 2013

This month we discuss the issue of diagnosing delirium in older hospital patients. Despite being linked to a range of poor outcomes, the syndrome is often missed and evidence on its measurement is sparse.Professor Alasdair MacLullich tells us how a d...Show More
Diagnosing conversion disorder; exercise to prevent falls in Parkinson’s patients

21:28 | Feb 15th, 2013

In this edition Richard Kanaan (Institute of Psychiatry, King’s College London) talks about his work on conversion disorder, and gives his advice for neurologists and psychiatrists on making this tricky diagnosis.And Vicki Goodwin (Peninsula College ...Show More
The natural history of Parkinson’s; the latest on MS and latitude

19:06 | Jan 29th, 2013

Current treatments for Parkinson’s ameliorate the core, motor symptoms. However as we look for therapies to modify the underlying course of the disease there’s a need to better understand its development. Jonathan Evans, from the Cambridge Centre for...Show More
Athleticism and ALS; understanding peripherally induced movement disorders

19:05 | Jan 29th, 2013

Movement disorders following head trauma are well recognised, but we know much less about those occuring after a peripheral injury. Diana van Rooijen, Leiden Medical Center, the Netherlands, tells us what her review on this group of conditions reveal...Show More
Thrombolysis for elderly stroke patients; disability with organically-unexplained symptoms

20:27 | Jan 29th, 2013

Intravenous thrombolysis is the only curative treatment for acute ischaemic stroke, but is only licensed for patients up to 80 years old. Dr Paul Guyler, Southend Hospital NHS Trust, UK, discusses the evidence for outcomes in those over this limit, a...Show More
Finger length ratio and ALS; psychotherapy for dizziness

10:58 | Jan 29th, 2013

Dizziness can significantly complicate peoples’ lives, especially if it does not have a satisfactory medical explanation. We talk to Dr Gabriele Schmid of the Department of Psychosomatic Medicine and Psychotherapy, Technical University of Munich, Ger...Show More
Frontotemporal dementia reviewed; temporal orientation and dementia

18:33 | Jan 29th, 2013

Recent clinical, neuropsychological, imaging, genetic and pathological developments have changed our understanding of frontotemporal dementia, its classification and criteria. Dr Jonathan Rohrer, Dementia Research Centre, UCL Institute of Neurology, ...Show More
Dementia and word knowledge; DBS for Parkinson’s

17:55 | Jan 29th, 2013

This month Robert Wilson, Rush University Medical Center, Chicago, USA, on how dementia affects our knowledge of words, and the neuropathology which underlies this.Also, the use of deep brain stimulation to treat Parkinson’s disease. Tom Foltynie des...Show More
Genes, vitamin D and MS; hysteria and hypnosis

17:12 | Jan 29th, 2013

It’s been known for years that the prevalence of MS increases the further you go from the equator, but not why. Roisin Lonergan, from St Vincent’s University Hospital, Dublin, Ireland, describes her investigations into a genetic factor and vitamin D ...Show More
Eye movements in motor neurone disease; work and multiple sclerosis

15:54 | Jan 29th, 2013

This month Harriet Vickers (BMJ’s multimedia intern), talks to Solveig Glad about how long patients with benign multiple sclerosis stay in work, and what could help them hold down jobs.Also Colette Donaghy explains how examining eye movements in amyo...Show More
October 2010

15:44 | Jan 29th, 2013

In this month’s podcast Dr Amal Al Sayegh tells us about psychological therapies for treatment of post-concussion syndrome, and Dr Serena Hung describes patient’s perceptions of dyskinesia in Parkinson’s disease.See also:Psychological approaches to t...Show More
Predicting adjustment to an ALS diagnosis

15:44 | Jan 29th, 2013

Tamara Matuz discusses her research looking for predictors for how well patients adjust to a diagnosis of ALS in southern Germany.
Microbleeds and abuse in dementia

14:07 | Jan 29th, 2013

In this month’s podcast David Werring from University College London talks about his research into the link between brain microbleeds and intercerebral haemmorhage. Claudia Cooper explains her research looking at abusive behaviour by dementia patient...Show More
Migrane co-morbidities

14:07 | Jan 29th, 2013

In this month’s podcast Dawn Buse from the Montefiore Headache Center, New York, talks about her research into co-morbidities in chronic migrane sufferers.See also: Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine s...Show More
The SCAN rule

11:00 | Jan 29th, 2013

Matthew Kiernan (editor of JNNP) interviews Caroline Lovelock about her paper: The SCAN rule: a clinical rule to reduce CT misdiagnosis of intracerebral haemorrhage in minor stroke. This paper was the editor’s choice in the March edition of JNNP.
Epilepsy and driving; Self awareness in dementia

18:18 | Jan 29th, 2013

In this second podcast Professor Matthew Kiernan talks to Dr Rhys Thomas about the law regarding sleep-related epilepsy and driving - this month’s editor’s choice paper.Also Duncan Jarvies talks to Dr Howard Rosen about his research into self awarene...Show More
Pregnancy and MS

13:53 | Jan 29th, 2013

We are delighted to offer you the inaugural podcast from JNNP. Recorded at BMA House London, our broadcast begins with a future vision for the journal from incoming Editor, Professor Matthew Kiernan based in Sydney. There then follows a discussion wi...Show More